7-Oxabicyclo(4.1.0)heptane, 3-(epoxyethyl)-
RTECS #
RN8640000
CAS #
Updated
December 2018
Molecular Weight
140.20
Molecular Formula
C8H12O2
Synonyms
1,2-Epoxy-4-(epoxyethyl)cyclohexane
1-Epoxyethyl-3,4-epoxycyclohexane
1-Ethyleneoxy-3,4-epoxycyclohexane
1-Vinyl-3-cyclohexene dioxide
3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane
3-Oxiranyl-7-oxabicyclo(4.1.0)heptane
4-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane
4-Vinlycyclohexene dioxide
4-Vinyl-1,2-cyclohexene diepoxide
4-Vinyl-1-cyclohexene diepoxide
4-Vinyl-1-cyclohexene dioxide
4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
NCI-C60139
UCET textile finish 11-74 (Obs.)
Vinyl cyclohexene diepoxide
Vinyl cyclohexene dioxide
Vinylcyclohexene diepoxide
1-Epoxyethyl-3,4-epoxycyclohexane
1-Ethyleneoxy-3,4-epoxycyclohexane
1-Vinyl-3-cyclohexene dioxide
3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane
3-Oxiranyl-7-oxabicyclo(4.1.0)heptane
4-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane
4-Vinlycyclohexene dioxide
4-Vinyl-1,2-cyclohexene diepoxide
4-Vinyl-1-cyclohexene diepoxide
4-Vinyl-1-cyclohexene dioxide
4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
NCI-C60139
UCET textile finish 11-74 (Obs.)
Vinyl cyclohexene diepoxide
Vinyl cyclohexene dioxide
Vinylcyclohexene diepoxide
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg | severe | SCCUR* -,9,1961 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | intraperitoneal/rat | 125 mg/kg | BJPCAL 6,235,1951 |
Cytogenetic Analysis | ovary/hamster | 37800 picograms/kg | NTPTR* NTP-TR-362,1989 |
DNA Damage | intraperitoneal/rat | 960 mg/kg | TXAPA9 139,394,1996 |
DNA Damage | ovary/mouse | 10 µmol/L | TOXID9 -,283,2008 |
DNA Damage | other cell types/human | 3.1 gm/L/3H | TXAPA9 261,154,2012 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 25 mmol/L | BSIBAC 56,1803,1980 |
mutation in mammalian somatic cells | lymphocyte/mouse | 25 ng/kg | NTPTR* NTP-TR-362,1989 |
mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (+/-enzymatic activation step) | MUREAV 66,367,1979 |
mutation in microorganisms | /Klebsiella pneumoniae | 1 mmol/L (-enzymatic activation step) | MUREAV 89,269,1981 |
mutation in microorganisms | /Saccharomyes cerevisiae | 25 mmol/L (-enzymatic activation step) | BSIBAC 56,1803,1980 |
sister chromatid exchange | ovary/hamster | 3730 picograms/kg | NTPTR* NTP-TR-362,1989 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | 4800 mg/kg (30D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Other effects on male | TOXID9 12,435,1992 |
intraperitoneal/rat | 1760 mg/kg (14D prior to copulation/0-7D pregnant) | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Ovaries, fallopian tubes | JTSCDR 34,SP59,2009 |
oral/mouse | 13468 mg/kg (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Urogenital system | TOXID9 14,164,1994 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 5000 mg/kg/10W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumors at site of application | BJPCAL 6,235,1951 |
skin/mouse | lowest published toxic dose: 56 gm/kg/47W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | JNCIAM 31,41,1963 |
skin/mouse | lowest published toxic dose: 51500 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTIS** PB90-219957/AS |
skin/mouse | lowest published toxic dose: 103000 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Ovarian tumors | NTIS** PB90-219957/AS |
skin/mouse | toxic dose: 90 gm/kg/74W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | AIHAAP 24,305,1963 |
skin/mouse | toxic dose: 12 gm/kg/9W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | BJPCAL 6,235,1951 |
skin/mouse | toxic dose: 10300 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Ovarian tumors | NTPTR* NTP-TR-362,1989 |
skin/mouse | lowest published toxic dose: 60000 mg/kg/60W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTIS** PB90-219957/AS |
skin/mouse | lowest published toxic dose: 60000 mg/kg/60W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Reproductive: Maternal effects: Ovaries, fallopian tubes | NTIS** PB90-219957/AS |
skin/rat | lowest published toxic dose: 31500 mg/kg/105W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTIS** PB90-219957/AS |
skin/rat | lowest published toxic dose: 39375 mg/kg/105W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTIS** PB90-219957/AS |
skin/rat | lowest published toxic dose: 31500 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTPTR* NTP-TR-362,1989 |
unreported route/mouse | lowest published toxic dose: 2800 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease Skin and Appendages: Tumors | RARSAM 3,193,1963 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Hamster, ovary | Inhibitor Concentration Low: 0.5 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 194,733,2016 |
In Vitro/Hamster, ovary | Inhibitor Concentration (50 percent kill): 1.4 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 194,733,2016 |
In Vitro/Hamster, ovary | Inhibitor Concentration Low: 1.5 mmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | JOETD7 194,733,2016 |
In Vitro/jtd | Inhibitor Concentration (50 percent kill): 0.8 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 194,733,2016 |
In Vitro/jtd | Inhibitor Concentration Low: 0.5 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 194,733,2016 |
In Vitro/ptd | Inhibitor Concentration Low: 30 µmol/L/4D | Endocrine: Other changes | TXAPA9 249,1,2010 |
In Vitro/ptd | Inhibitor Concentration Low: 30 µmol/L/8D | In Vitro Toxicity Studies: Other assays | TXAPA9 249,1,2010 |
In Vitro/ptd | Inhibitor Concentration Low: 30 µmol/L/8D | Reproductive: Maternal effects: Oogenesis | TXAPA9 258,118,2012 |
In Vitro/ptd | Inhibitor Concentration Low: 30 µmol/L/4D | In Vitro Toxicity Studies: Other assays | TXAPA9 258,118,2012 |
inhalation/rat | lethal concentration (50 percent kill): 800 ppm/4H | SCCUR* -,9,1961 | |
intraperitoneal/mouse | lowest published toxic dose: 80 mg/kg | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases Biochemical: Metabolism (intermediary): Other | TOXID9 1,93,2001 |
intraperitoneal/rat | lowest published toxic dose: 80 mg/kg | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 66,373,2002 |
intraperitoneal/rat | lowest published toxic dose: 80 mg/kg | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | BIREBV 67,718,2002 |
intraperitoneal/rat | lowest published toxic dose: 320 mg/kg | Reproductive: Maternal effects: Oogenesis | REPTED 19,71,2004 |
oral/rat | lethal dose (50 percent kill): 2130 mg/kg | SCCUR* -,9,1961 | |
skin/mouse | lowest published lethal dose: 3216 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory stimulation Skin: After systemic exposure: Dermatitis, other | NTPTR* NTP-TR-362,1989 |
skin/rabbit | lethal dose (50 percent kill): 620 µL/kg | UCDS** 9/19/1972 | |
unreported route/mouse | lowest published toxic dose: 79.914 mg/kg | Reproductive: Maternal effects: Ovaries, fallopian tubes | TXAPA9 230,109,2008 |
unreported route/rabbit | lethal dose (50 percent kill): 680 µg/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Other changes | BSIBAC 56,1803,1980 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intramuscular/rat | lowest published toxic dose: 400 mg/kg/10D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AEHLAU 2,50,1961 |
intraperitoneal/mouse | lowest published toxic dose: 4000 mg/kg/5D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in testicular weight | REPTED 9,359,1995 |
intraperitoneal/mouse | lowest published toxic dose: 300 mg/kg/30D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | REPTED 5,379,1991 |
intraperitoneal/mouse | lowest published toxic dose: 1199 mg/kg/15D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TXAPA9 221,215,2007 |
intraperitoneal/mouse | lowest published toxic dose: 1200 mg/kg/5D- intermittent | Reproductive: Maternal effects: Oogenesis Related to Chronic Data: Changes in ovarian weight | REPTED 26,116,2008 |
intraperitoneal/mouse | lowest published toxic dose: 1600 mg/kg/10D- intermittent | Endocrine: Change in LH Endocrine: Change in gonadotropins Reproductive: Maternal effects: Ovaries, fallopian tubes | RTOPDW 81,223,2016 |
intraperitoneal/mouse | lowest published toxic dose: 1600 mg/kg/10D- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Maternal effects: Menstrual cycle changes or disorders | RTOPDW 81,223,2016 |
intraperitoneal/rat | lowest published toxic dose: 1120 mg/kg/2W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | JTSCDR 34,SP53,2009 |
intraperitoneal/rat | lowest published toxic dose: 560 mg/kg/4W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | JTSCDR 34,SP53,2009 |
intraperitoneal/rat | lowest published toxic dose: 1760 mg/kg/22D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 34,SP59,2009 |
intraperitoneal/rat | lowest published toxic dose: 1200 mg/kg/15D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 203,114,2005 |
intraperitoneal/rat | lowest published toxic dose: 1200 mg/kg/15D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 60,248,2001 |
intraperitoneal/rat | lowest published toxic dose: 1200 mg/kg/15D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 60,251,2001 |
intraperitoneal/rat | lowest published toxic dose: 2400 mg/kg/30D- intermittent | Endocrine: Change in gonadotropins Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Menstrual cycle changes or disorders | REPTED 16,775,2002 |
intraperitoneal/rat | lowest published toxic dose: 800 mg/kg/10D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | BIREBV 67,718,2002 |
oral/mouse | lowest published toxic dose: 65 gm/kg/13W- intermittent | Gastrointestinal: Other changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | FAATDF 14,745,1990 |
oral/rat | lowest published toxic dose: 560 mg/kg/2W- continuous | Reproductive: Maternal effects: Oogenesis | REPTED 17,273,2003 |
oral/rat | lowest published toxic dose: 2800 mg/kg/28D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ETOPFR 45,28,2016 |
oral/rat | lowest published toxic dose: 2800 mg/kg/28D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ETOPFR 45,28,2016 |
oral/rat | lowest published toxic dose: 32500 mg/kg/13W- intermittent | Gastrointestinal: Other changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | FAATDF 14,745,1990 |
skin/mouse | lowest published toxic dose: 6832 mg/kg/14D- intermittent | Liver: Changes in liver weight Endocrine: Changes in thymus weight Skin: After systemic exposure: Dermatitis, other | NTPTR* NTP-TR-362,1989 |
skin/mouse | lowest published toxic dose: 26 gm/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Skin: After systemic exposure: Dermatitis, other | NTPTR* NTP-TR-362,1989 |
skin/rat | lowest published toxic dose: 6552 mg/kg/14D- intermittent | Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Changes in thymus weight | NTPTR* NPT-TR-362,1989 |
skin/rat | lowest published toxic dose: 19500 mg/kg/13W- intermittent | Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other glands | FAATDF 14,745,1990 |
unreported route/mouse | lowest published toxic dose: 1200 mg/kg/5D- intermittent | Endocrine: Other changes Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 90,80,2006 |
unreported route/rat | lowest published toxic dose: 1200 mg/kg/15D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 66,373,2002 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 11,141,1976 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 60,361,1994 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 11,141,1976 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 60,361,1994 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 60,361,1994 |
TOXICOLOGY REVIEW | JTSCDR 34,SP1,2009 | |
TOXICOLOGY REVIEW | REPTED 49,117,2014 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL CYCLOHEXENE DIOXIDE-air | 10H Carcinogen time-weighted average 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code M1392; Number of Industries 14; Total Number of Facilities 107; Number of Occupations 24; Total Number of Employees Exposed 6224; Total Number of Female Employees Exposed 1718 | |
National Occupational Hazard Survey 1974 | Hazard Code M1392; Number of Industries 7; Total Number of Facilities 181; Number of Occupations 11; Total Number of Employees Exposed 2028 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat | |
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health