The National Institute for Occupational Safety and Health (NIOSH)

Nonane

RTECS #

RA6115000

CAS #

111-84-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

128.29

Molecular Formula

C₉H₂₀

Synonyms

n-Nonane
Nonane (ACGIH)
Shellsol 140

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /pig	250 µL/24H	mild	TXCYAC 161,1,2001
skin /rat	300 µL/4D open irritation test	moderate	TIHEEC 20,109,2004

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 3200 ppm/4H		TXAPA9 44,53,1978
inhalation/rat	lethal concentration (50 percent kill): 17000 mg/m³/4H		VCVGH* -,39,1990
intravenous/mouse	lethal dose (50 percent kill): 218 mg/kg		JPMSAE 67,566,1978
skin/rat	lowest published toxic dose: 0.92 mL/kg/2H	Skin: After topical application: Primary irritation Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOLED5 185,168,2009

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1600 ppm/6H/13W- intermittent	Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 44,53,1978
inhalation/rat	lowest published toxic concentration: 8100 mg/m³/6H/1W- intermittent	Eye: Conjunctiva irritation Behavioral: Tremor Behavioral: Ataxia	VCVGH* -,39,1990
inhalation/rat	lowest published toxic concentration: 8400 mg/m³/6H/63D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	VCVGH* -,39,1990
intraperitoneal/rat	lowest published toxic dose: 5 mg/kg/7D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	ENVRAL 22,271,1980
oral/mouse	lowest published toxic dose: 90 gm/kg/90D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	TOXID9 54,397,2000
oral/rat	lowest published toxic dose: 90 gm/kg/90D- intermittent	Endocrine: Changes in adrenal weight Related to Chronic Data: Changes in ovarian weight	TOXID9 54,397,2000
skin/rat	lowest published toxic dose: 1200 µL/kg/4D- intermittent	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TIHEEC 20,109,2004

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 200 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (1050 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm (1065 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 200 ppm (1050 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 200 ppm (1100 mg/m³), short term exposure limit 250 ppm (1300 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 200 ppm (1050 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 200 ppm (1100 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 200 ppm (1050 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 200 ppm (1050 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 200 ppm (1050 mg/m³);short term exposure limit 250 ppm (1300 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (1050 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 100 ppm (525 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 200 ppm (1049 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 150 ppm (800 mg/m³);short term exposure limit 200 ppm (1100 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 200 ppm (1050 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1050 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NONANE-air	10H time-weighted average 200 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M4718; Number of Industries 14; Total Number of Facilities 738; Number of Occupations 16; Total Number of Employees Exposed 7277; Total Number of Female Employees Exposed 717
National Occupational Hazard Survey 1974	Hazard Code M4718; Number of Industries 2; Total Number of Facilities 57; Number of Occupations 2; Total Number of Employees Exposed 1231

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health

Follow NIOSH

NIOSH Homepage