Nickel carbonyl

RTECS #

QR6300000

CAS #

13463-39-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

170.75

Molecular Formula

C₄NiO₄

Synonyms

Nichel tetracarbonile (Italian)
Nickel carbonyl (ACGIH:OSHA)
Nickel carbonyle (French)
Nickel tetracarbonyl
Nickel tetracarbonyle (French)
Nikkeltetracarbonyl (Dutch)
RCRA waste number P073
Tetracarbonyl nickel

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	60 mg/m³/15M (8D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	TXAPA9 45,345,1978
inhalation/rat	120 mg/m³/15M (8D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 45,345,1978
inhalation/rat	160 mg/m³/15M (7D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	SCIEAS 203,550,1979
inhalation/hamster	60 mg/m³/15M (5D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Respiratory system Reproductive: Other developmental abnormalities	NTIS** DOE/EV/03140-5
inhalation/hamster	60 mg/m³/15M (5D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	NTIS** DOE/EV/03140-5
inhalation/hamster	60 mg/m³/15M (4D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Respiratory system	48ECAY 3,301,1980
intravenous/rat	25 mg/kg (7D pregnant)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	50WKA3 -,399,1983
intravenous/rat	25 mg/kg (7D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	50WKA3 -,399,1983

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 250 mg/m³/30M/1Y	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	AJCPAI 35,203,1961
inhalation/rat	toxic concentration: 4 ppm/30M/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	AJPAA4 46,1027,1965
intravenous/rat	lowest published toxic dose: 54 mg/kg/20W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	CNREA8 32,2253,1972

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lethal concentration (50 percent kill): 1890 mg/m³/30M		EQSSDX 1,1,1975
inhalation/cat	lethal concentration (50 percent kill): 1900 mg/m³/30M	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Liver function tests impaired Liver: Changes in liver weight	VCVN5* -,501,1989
inhalation/Dog	Lowest published lethal concentration: 360 ppm/90M		JOHYAY 7,525,1907
inhalation/human	Lowest published lethal concentration: 0.003 pph/1M	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Respiratory obstruction Kidney, Ureter, and Bladder: Renal function tests depressed	VCVN5* -,503,1989
inhalation/human	lowest published toxic concentration: 7 mg/m³	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature increase	GISAAA 22(11),30,1957
inhalation/human	Lowest published lethal concentration: 30 ppm/30M		AEHLAU 23,373,1971
inhalation/mouse	lethal concentration (50 percent kill): 0.01 gm/m³/2H		TPKVAL 9,7,1967
inhalation/mouse	lethal concentration (50 percent kill): 1.4 ppm/2H		TPKVAL 9,7,1967
inhalation/mouse	Lowest published lethal concentration: 0.04 gm/m³/2H	Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes in urine composition	TPKVAL 10,144,1968
inhalation/mouse	lethal concentration (50 percent kill): 67 mg/m³/30M	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Liver function tests impaired Liver: Changes in liver weight	VCVN5* -,501,1989
inhalation/mouse	lethal concentration (50 percent kill): 67 mg/m³/30M	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Other changes	AMIHBC 8,48,1953
inhalation/rabbit	Lowest published lethal concentration: 300 mg/m³/30M		YAKUD5 22,455,1980
inhalation/rat	lethal concentration (50 percent kill): 873 mg/m³/30M	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Liver function tests impaired Liver: Changes in liver weight	VCVN5* -,501,1989
inhalation/rat	lethal concentration (50 percent kill): 151 mg/m³/2H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Liver function tests impaired Liver: Changes in liver weight	VCVN5* -,501,1989
inhalation/rat	lethal concentration (50 percent kill): 81.5 mg/m³/4H	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Liver function tests impaired Liver: Changes in liver weight	VCVN5* -,501,1989
inhalation/rat	lethal concentration (50 percent kill): 35 ppm/30M		AJCPAI 26,107,1956
intraperitoneal/rat	lethal dose (50 percent kill): 39 mg/kg	Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AEHLAU 14,604,1967
intravenous/rat	lethal dose (50 percent kill): 64 mg/kg	Biochemical: Metabolism (intermediary): Other	RCOCB8 2,545,1971
skin/rabbit	lowest published toxic dose: 0.1 mL/kg	Behavioral: Somnolence (general depressed activity) Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Respiratory stimulation	TPKVAL 10,144,1968
subcutaneous/rat	lethal dose (50 percent kill): 63 mg/kg	Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AEHLAU 14,604,1967

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 2500 µg/m³/4D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL (10),144,1968
inhalation/rat	lowest published toxic concentration: 0.0005 gm/m³/14D- intermittent	Skin and Appendages: Other: Breast Reproductive: Tumorigenic effects: Ovarian tumors Reproductive: Tumorigenic effects: Uterine tumors	TPKVAL 10,144,1968
inhalation/rat	lowest published toxic concentration: 30 mg/m³/30M/52W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 16,480,1957
inhalation/rat	lowest published toxic concentration: 5.8 mg/m³/4H/3W- intermittent	Lung, Thorax, or Respiration: Respiratory depression Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVN5* -,504,1989

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 ppm(Ni)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.2 mg(Ni)/m3 (inhal)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMSUDL 7,264,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 49,257,1990
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 100C,211,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 100C,210,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 100C,211,2012
TOXICOLOGY REVIEW		ACLSCP 3,156,1973
TOXICOLOGY REVIEW		ANAEA3 35,165,1975
TOXICOLOGY REVIEW		FEPRA7 35,89,1976
TOXICOLOGY REVIEW		FCTXAV 9,105,1971
TOXICOLOGY REVIEW		85DHAX Ni,168,1975
TOXICOLOGY REVIEW		PEXTAR 12,102,1969
TOXICOLOGY REVIEW		DICHAK 54,527,1968
TOXICOLOGY REVIEW		CTOXAO 12,601,1978
TOXICOLOGY REVIEW		CREOH* 42,35,2002
TOXICOLOGY REVIEW		ENTOX* -,220,2005
TOXICOLOGY REVIEW		MUREAV 533,92,2003
TOXICOLOGY REVIEW		HBTME* ,743,2007
TOXICOLOGY REVIEW		HUTOX* -,515,1996
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	HUMAN CARCINOGEN	DTLWS* 3,24,1973
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.001 ppm (0.007 mg/m³)	DTLWS* 3,24,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.007 ppm (0.001 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.05 ppm (0.12 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg(Ni)/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	TRK-TMW 0.05 ppm (0.35 mg/m³);KZW 0.2 ppm (1.4 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 ppm (0.12 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.001 ppm (0.007 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.001 ppm (0.007 mg/m³), short term exposure limit 0.003 ppm (0.021 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.05 ppm (0.12 mg/m³), C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 0.15 mg/m³, short term exposure limit 0.15 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.001 ppm (0.007 mg/m³), carc, skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.001 ppm (0.007 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.001 ppm (0.007 mg(Ni)/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.05 ppm (0.35 mg(Ni)/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 ppm (0.12 mg(Ni)/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.001 ppm (0.007 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,05 ppm (0,35 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.003 mg/m³, MAR2004
Occupational Exposure Limit-SWEDEN	time-weighted average 0.001 ppm (0.007 mg/m³), Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 mg(Ni)/m³, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 ppm (0.35 mg/m³), skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.001 ppm (0.007 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.35 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.001 ppm (0.007 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.001 ppm (0.007 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	short term exposure limit 0.1 ppm (0.24 mg(Ni)/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL CARBONYL-air	10H Carcinogen time-weighted average 0.001 ppm	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nickel carbonyl, 6007
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health