Mineral oil

RTECS #

PY8030000

CAS #

8012-95-1; 39355-35-6; 79956-36-8; 83046-05-3
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Adepsine oil
Alboline
Bayol 55
Bayol F
Blandlube
Crystol 325
Crystosol
Glymol
Kondremul
Liquid paraffin
Neo-cultol
Nujol
Oil mist, mineral
Oil mist, mineral (ACGIH:OSHA)
Paraffin oil
Paroleine
Petrogalar
Primol 355
Primol D
Saxol
USP mineral oil

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg	moderate	AJOPAA 29,1363,1946
skin /guinea pig	100 mg/24H	mild	CTOIDG 94(8),41,1979
skin /rabbit	100 mg/24H	mild	CTOIDG 94(8),41,1979

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/man	lowest published toxic concentration: 5 mg/m³/5Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Reproductive: Tumorigenic effects: Testicular tumors	JJOMDZ 23,333,1981
intraperitoneal/mouse	lowest published toxic dose: 14 gm/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Leukemia Lung, Thorax, or Respiration: Bronchogenic carcinoma	NATUAS 193,1086,1962
intraperitoneal/mouse	toxic dose: 60 gm/kg/17W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Tumors	CNREA8 38,703,1978
intraperitoneal/mouse	toxic dose: 60 gm/kg/17W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease	IMMUAM 17,481,1969
intraperitoneal/mouse	toxic dose: 50 gm/kg/9W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Tumors Immunological Including Allergic: Decreased immune response	IJCNAW 6,422,1970
intraperitoneal/mouse	toxic dose: 72 gm/kg/26W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Tumors	JOIMA3 92,747,1962
skin/mouse	lowest published toxic dose: 332 gm/kg/20W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	ANYAA9 132,439,1965

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 4 gm/m³/4H	Behavioral: Somnolence (general depressed activity) Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 -,221,2008
intraperitoneal/mouse	lowest published toxic dose: 20 mL/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Autoimmune (multiple organ involvement) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	BIPHEX 58,325,2004
oral/mouse	lethal dose (50 percent kill): 22 gm/kg		ATXKA8 30,243,1973

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 70 mg/m³/2W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Lung, Thorax, or Respiration: Other changes	VCVPS* -,91,1998
oral/rat	lowest published toxic dose: 900 mg/kg/90D- continuous	Immunological Including Allergic: Decrease in humoral immune response	TOXID9 60,30,2001
skin/mouse	lowest published toxic dose: 20800 µL/kg/13W- intermittent	Liver: Changes in liver weight	NTPTR* NIH-92-3340
skin/rat	lowest published toxic dose: 5200 µL/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight	NTPTR* NIH-92-3340

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 100F,193,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 100F,193,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT Group 1
TOXICOLOGY REVIEW		PAASAH 54,171,1959
TOXICOLOGY REVIEW		BIPHEX 58,325,2004
TOXICOLOGY REVIEW		DIMON* 39,678,1993
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		BPRCG* 21,849,2007
TOXICOLOGY REVIEW		SFDRA* 38,379,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,225,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 mg/m³ (particulate)	DTLWS* 3,25,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 mg/m³, MAY2011
Occupational Exposure Limit-HUNGARY	ceiling concentration 5 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 3 mg/m³ (mist), 1 carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, short term exposure limit 10 ppm, JAN2002
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 5 mg/m³, MAC(short term exposure limit) 10 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³, JUN2005
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code T1542; Number of Industries 275; Total Number of Facilities 49328; Number of Occupations 178; Total Number of Employees Exposed 1100229; Total Number of Female Employees Exposed 433405
National Occupational Hazard Survey 1974	Hazard Code T1542; Number of Industries 3; Total Number of Facilities 22; Number of Occupations 7; Total Number of Employees Exposed 698

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oil mist, mineral, 5026
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health