1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-

RTECS #

PC8575000

CAS #

143-50-0
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

490.60

Molecular Formula

C₁₀Cl₁₀O

Synonyms

1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decano-4-one
Chlordecone
Ciba 8514
Clordecone
Compound 1189
Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
Decachloroketone
Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one
Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one
Decachlorotetracyclodecanone
Decachlorotetrahydro-4,7-methanoindeneone
ENT 16,391
GC 1189
General chemicals 1189
Kepone
NCI-C00191
RCRA waste number U142

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
other mutation test systems	liver/rat	100 µmol/L	TIVIEQ 4,179,1990
sister chromatid exchange	ovary/hamster	1700 µg/L	EMMUEG 10(Suppl 10),1,1987
specific locus test	intraperitoneal/mouse	71.3 µmol/L	MUREAV 608,29,2006
sperm morphology	oral/quail	200 ppm/42D-continuous	TXAPA9 43,535,1978

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	25 mg/kg (1D prior to copulation)	Reproductive: Other effects on female	REPTED 5,65,1991
intraperitoneal/rat	50 mg/kg (1D prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	NTOTDY 8,121,1986
intraperitoneal/rat	50 mg/kg (1D prior to copulation)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	REPTED 1,105,1987/1988
intraperitoneal/rat	75 mg/kg (1D prior to copulation)	Reproductive: Maternal effects: Uterus, cervix, vagina	REPTED 5,65,1991
intraperitoneal/rat	60 mg/kg (18-22D preg/7D after birth)	Reproductive: Effects on newborn: Physical	HBPTO* 1,733,2001
intraperitoneal/rat	5 mg/kg (16D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral	NETEEC 29,255,2007
oral/mouse	16500 µg/kg (4W male/4W prior to copulation)	Reproductive: Effects on fertility: Other measures of fertility	JEENAI 58,754,1965
oral/mouse	120 mg/kg (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 38,189,1976
oral/mouse	100 mg/kg (8-12D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JTEHD6 10,541,1982
oral/mouse	120 mg/kg (8-12D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TCMUD8 6,361,1986
oral/mouse	72 mg/kg (30D male/30D prior to copulation)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	HBPTO* 1,732,2001
oral/rat	105 mg/kg (14-20D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects	ENVRAL 18,437,1979
oral/rat	40 mg/kg (1D prior to copulation)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	VCVGK* -,483,1994
oral/rat	25 mg/kg (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	VCVGK* -,484,1994
oral/mouse	60 mg/kg (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	VCVGK* -,484,1994
oral/rat	47 mg/kg (60D pre-12D after birth)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects	NRTXDN 3,131,1982
oral/rat	30.9 mg/kg (60D pre-21D after birth)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Delayed effects	NRTXDN 3,119,1982
oral/rat	88.2 mg/kg (7W male)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	FEPRA7 37,501,1978
oral/rat	63 mg/kg (2-22D preg/21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	TOLED5 4,247,1979
oral/rat	42 mg/kg (2-22D preg/21D after birth)	Reproductive: Effects on newborn: Other postnatal measures or effects	TXAPA9 41,142,1977
oral/rat	100 mg/kg (7-16D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis	TXAPA9 38,189,1976
oral/rat	60 mg/kg (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 38,189,1976
oral/rat	17 mg/kg (1-22D preg/12D after birth)	Reproductive: Effects on newborn: Behavioral	FEPRA7 40,667,1981
oral/rat	18 mg/kg (5D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	TOLED5 30,237,1986
subcutaneous/rat	2 mg/kg (2D prior to copulation)	Reproductive: Maternal effects: Uterus, cervix, vagina	ENVRAL 16,131,1978
subcutaneous/rat	10 mg/kg (2D prior to copulation)	Reproductive: Maternal effects: Ovaries, fallopian tubes	ENVRAL 16,131,1978

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 1200 mg/kg/80W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-b,1976
oral/mouse	toxic dose: 1340 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	AIHAAP 37,680,1976
oral/mouse	toxic dose: 1550 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	AIHAAP 37,680,1976
oral/mouse	toxic dose: 1344 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	JTEHD6 4,895,1978
oral/rat	lowest published toxic dose: 200 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NEOLA4 26,231,1979
oral/rat	toxic dose: 504 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Skin and Appendages: Tumors	JTEHD6 4,895,1978
oral/rat	toxic dose: 670 mg/kg/80W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-b,1976

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
implant/mouse	lowest published toxic dose: 200 mg/kg	Endocrine: Changes in spleen weight Blood: Changes in spleen Biochemical: Metabolism (intermediary): Other proteins	TOLED5 183,1,2008
intraperitoneal/mouse	lowest published toxic dose: 5 mg/kg	Liver: Other changes Biochemical: Metabolism (intermediary): Other	TOXID9 -,167,2008
intraperitoneal/mouse	lowest published toxic dose: 15 mg/kg	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Lipids including transport	TXAPA9 233,193,2008
intraperitoneal/rat	lowest published toxic dose: 500 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	HBPTO* 1,733,2001
intraperitoneal/rat	lowest published toxic dose: 80 mg/kg	Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes	VCVGK* -,483,1994
intraperitoneal/rat	lowest published toxic dose: 50 mg/kg	Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	NRTXDN 8,15,1987
intraperitoneal/rat	lowest published toxic dose: 75 mg/kg	Endocrine: Changes in adrenal weight	NRTXDN 8,15,1987
intraperitoneal/rat	lowest published toxic dose: 40 mg/kg	Behavioral: Tremor	PSEBAA 195,44,1990
intraperitoneal/rat	lowest published toxic dose: 60 mg/kg	Endocrine: Other changes Blood: Other changes	PSEBAA 195,44,1990
oral/chicken	lethal dose (50 percent kill): 480 mg/kg		ENTOX* -,542,2005
oral/Dog	lethal dose (50 percent kill): 250 mg/kg		ENTOX* -,542,2005
oral/Dog	lethal dose (50 percent kill): 250 mg/kg	Behavioral: Tremor	VCVGK* -,483,1994
oral/quail	lethal dose (50 percent kill): 237 mg/kg		JRPFA4 48,371,1976
oral/rabbit	lethal dose (50 percent kill): 65 mg/kg		PCOC** -,642,1966
oral/rabbit	lethal dose (50 percent kill): 65 mg/kg	Behavioral: Tremor	VCVGK* -,483,1994
oral/rat	lethal dose (50 percent kill): 91300 µg/kg		NTOTDY 5,91,1983
oral/rat	lowest published toxic dose: 40 mg/kg	Endocrine: Effect on menstrual cycle	VCVGK* -,483,1994
oral/rat	lethal dose (50 percent kill): 96 mg/kg	Behavioral: Tremor	VCVGK* -,483,1994
oral/Trout	lowest published toxic dose: 0.4 mg/kg/33W	Endocrine: Estrogenic	TIVIEQ 36,31,1996
skin/rabbit	lethal dose (50 percent kill): 345 mg/kg		GUCHAZ 6,96,1973
skin/rat	lethal dose (50 percent kill): 2000 mg/kg		VCVGK* -,483,1994
subcutaneous/rat	lowest published toxic dose: 100 mg/kg	Behavioral: Tremor	NRTXDN 3,111,1982
subcutaneous/rat	lowest published toxic dose: 100 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: Tremor Endocrine: Other changes	NRTXDN 3,111,1982
subcutaneous/rat	lowest published toxic dose: 75 mg/kg	Endocrine: Other changes	TXAPA9 100,506,1989
subcutaneous/rat	lowest published toxic dose: 100 mg/kg	Endocrine: Adrenal cortex hypoplasia Endocrine: Other changes	NTOTDY 7,33,1985
unreported route/mammal (species unspecified)	lowest published toxic dose: 25 mg/kg	Brain and Coverings: Other degenerative changes	VCVGK* -,483,1994
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 126 mg/kg		30ZDA9 -,65,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
implant/mouse	lowest published toxic dose: 400 mg/kg/14W- continuous	Kidney, Ureter, and Bladder: Renal function tests depressed	TXCYAC 218,81,2006
implant/mouse	lowest published toxic dose: 40 mg/kg/60D- continuous	Immunological Including Allergic: Autoimmune (multiple organ involvement)	TXCYAC 218,81,2006
implant/mouse	lowest published toxic dose: 120 mg/kg/22W- continuous	Kidney, Ureter, and Bladder: Renal function tests depressed Kidney, Ureter, and Bladder: Other changes	TXCYAC 218,81,2006
intraperitoneal/mouse	lowest published toxic dose: 83 mg/kg/10D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina	TXAPA9 49,151,1979
intraperitoneal/mouse	lowest published toxic dose: 199.8 mg/kg/6D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina	TXAPA9 49,151,1979
intraperitoneal/mouse	lowest published toxic dose: 277.6 mg/kg/4D- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina	TXAPA9 49,151,1979
intraperitoneal/mouse	lowest published toxic dose: 160 mg/kg/20D- intermittent	Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Ovaries, fallopian tubes	TOSCF2 68,473,2002
intraperitoneal/mouse	lowest published toxic dose: 80 mg/kg/2W- intermittent	Reproductive: Maternal effects: Ovaries, fallopian tubes	TOXID9 60,383,2001
intraperitoneal/rat	lowest published toxic dose: 12500 µg/kg/5D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	PCBPBS 18,113,1982
oral/Dog	lowest published toxic dose: 560 mg/kg/2.5Y- continuous	Cardiac: Changes in heart weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight	TXAPA9 48,29,1979
oral/hamster	lowest published toxic dose: 12 mg/kg/2D- intermittent	Endocrine: Estrogenic	HBPTO* 1,732,2001
oral/mouse	lowest published toxic dose: 240 mg/kg/30D- intermittent	Endocrine: Estrogenic Endocrine: Effect on menstrual cycle	HBPTO* 1,732,2001
oral/mouse	lowest published toxic dose: 180 mg/kg/18D- intermittent	Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NRTXDN 2,113,1981
oral/mouse	lowest published toxic dose: 150 mg/kg/3D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Tremor Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	TOLED5 6,275,1980
oral/mouse	lowest published toxic dose: 320 mg/kg/10W- intermittent	Liver: Changes in liver weight	BECTA6 39,615,1987
oral/mouse	lowest published toxic dose: 14 mg/kg/14D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	VCVGK* -,483,1994
oral/mouse	lowest published toxic dose: 60 mg/kg/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,484,1994
oral/mouse	lowest published toxic dose: 224 mg/kg/4W- intermittent	Reproductive: Maternal effects: Ovaries, fallopian tubes	VCVGK* -,484,1994
oral/mouse	lowest published toxic dose: 175 mg/kg/7W- intermittent	Liver: Changes in liver weight	TOLED5 255,1,2016
oral/quail	lowest published toxic dose: 1470 mg/kg/42D- continuous	Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Related to Chronic Data: Changes in testicular weight	TXAPA9 43,535,1978
oral/rat	lowest published toxic dose: 126 mg/kg/12W- continuous	Reproductive: Paternal effects: Testes, epididymis, sperm duct	HBPTO* 1,732,2001
oral/rat	lowest published toxic dose: 81 mg/kg/90D- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	HBPTO* 1,733,2001
oral/rat	lowest published toxic dose: 307 mg/kg/15W- intermittent	Behavioral: Alteration of operant conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Body temperature increase	NTOTDY 5,91,1983
oral/rat	lowest published toxic dose: 912 mg/kg/2Y- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 48,29,1979
oral/rat	lowest published toxic dose: 100 mg/kg/10D- intermittent	Endocrine: Changes in spleen weight Blood: Changes in other cell count (unspecified) Immunological Including Allergic: Decreased immune response	JTEHD6 15,561,1985
oral/rat	lowest published toxic dose: 162 mg/kg/90D- continuous	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TXAPA9 59,262,1981
oral/rat	lowest published toxic dose: 287 mg/kg/35D- continuous	Liver: Other changes Liver: Changes in liver weight	TXAPA9 58,132,1981
oral/rat	lowest published toxic dose: 75 mg/kg/3D- intermittent	Behavioral: Tremor Musculoskeletal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	BECTA6 25,262,1980
oral/rat	lowest published toxic dose: 25 mg/kg/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,484,1994
oral/rat	lowest published toxic dose: 96.12 mg/kg/10D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Blood: Other changes	JESEDU A22,639,1987
oral/rat	lowest published toxic dose: 49.06 mg/kg/10D- intermittent	Liver: Changes in liver weight	JESEDU A22,639,1987
oral/rat	lowest published toxic dose: 1.68 mg/kg/28D- continuous	Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	JTEHD6 6,421,1980
oral/rat	lowest published toxic dose: 1600 mg/kg/8D- continuous	Liver: Other changes Endocrine: Other changes	VCVGK* -,484,1994
oral/rat	lowest published toxic dose: 140 mg/kg/14D- continuous	Liver: Other changes Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,484,1994
oral/rat	lowest published toxic dose: 140 mg/kg/14D- continuous	Liver: Other changes Endocrine: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,484,1994
oral/rat	lowest published toxic dose: 9 mg/kg/15D- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HBPTO* 1,880,2001
oral/rat	lowest published toxic dose: 31.5 mg/kg/105D- continuous	Brain and Coverings: Other degenerative changes	NRTXDN 3,119,1982
oral/rat	lowest published toxic dose: 50.4 mg/kg/4W- continuous	Endocrine: Androgenic	FEPRA7 37,501,1978
oral/rat	lowest published toxic dose: 84 mg/kg/8W- continuous	Endocrine: Effect on menstrual cycle	FEPRA7 37,501,1978
oral/rat	lowest published toxic dose: 105 mg/kg/10W- continuous	Endocrine: Estrogenic Endocrine: Change in LH Related to Chronic Data: Changes in uterine weight	FEPRA7 37,501,1978
skin/rat	lowest published toxic dose: 75 mg/kg/15D- intermittent	Related to Chronic Data: Changes in testicular weight	VCVGK* -,484,1994
subcutaneous/mouse	lowest published toxic dose: 3 mg/kg/3D- intermittent	Related to Chronic Data: Changes in uterine weight Endocrine: Estrogenic	EVHPAZ 104,1296,1996
unreported route/mouse	lowest published toxic dose: 840 mg/kg/4W- intermittent	Liver: Other changes Liver: Tumors	VCVGK* -,484,1994
unreported route/mouse	lowest published toxic dose: 6 mg/kg/10D- continuous	Reproductive: Maternal effects: Uterus, cervix, vagina	HBPTO* 1,732,2001
unreported route/rat	lowest published toxic dose: 700 mg/kg/4W- intermittent	Behavioral: Tremor	VCVGK* -,484,1994
unreported route/rat	lowest published toxic dose: 2250 mg/kg/90D- intermittent	Liver: Changes in liver weight	VCVGK* -,484,1994
unreported route/rat	lowest published toxic dose: 730 mg/kg/2Y- intermittent	Liver: Tumors	VCVGK* -,484,1994

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 20,67,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 20,67,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMSUDL 7,56,1987
TOXICOLOGY REVIEW		STEVA8 9,1,1978
TOXICOLOGY REVIEW		JTEHD6 4,895,1978
TOXICOLOGY REVIEW		CTOXAO 13,231,1978
TOXICOLOGY REVIEW		JEPTDQ 2(3),671,1979
TOXICOLOGY REVIEW		ENTOX* -,542,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HETOEA 25,413,2006
TOXICOLOGY REVIEW		REPTED 26,1,2008
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		MUREAV 672,17,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		TPHSDY 29,116,2008
TOXICOLOGY REVIEW		HETOEA 26,321,2007
TOXICOLOGY REVIEW		FESTAS 90,911,2008
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TXCYAC 307,74,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		NETEEC 52,68,2015

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-JAPAN	2B carc, MAY2012

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEPONE-air	10H Carcinogen time-weighted average 0.001 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code M2969; Number of Industries 1; Total Number of Facilities 280; Number of Occupations 2; Total Number of Employees Exposed 12600

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264354)
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8899
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Kepone, 5508
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health