Methane, triiodo-
RTECS #
PB7000000
CAS #
Updated
June 2017
Molecular Weight
393.72
Molecular Formula
CHI3
Synonyms
Carbon triiodide
Dezinfekt V
Iodoform
Iodoform (ACGIH)
Jodoform (Czech)
NCI-C04568
Triiodomethane
Trijodmethane (Czech)
Dezinfekt V
Iodoform
Iodoform (ACGIH)
Jodoform (Czech)
NCI-C04568
Triiodomethane
Trijodmethane (Czech)
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | other cell types/human | 100 µmol/L/3H | MUREAV 649,45,2008 |
morphological transform | embryo/hamster | 10 mg/L | SHIGAZ 74,1385,1987 |
mutation in microorganisms | /Salmonella typhimurium | 67 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
sister chromatid exchange | embryo/hamster | 1 mg/L | SHIGAZ 74,1385,1987 |
Unscheduled DNA Synthesis | embryo/hamster | 1 mg/L | SHIGAZ 74,1385,1987 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lethal concentration (50 percent kill): 165 ppm/7H | Lung, Thorax, or Respiration: Respiratory stimulation | JTEHD6 8,59,1981 |
inhalation/rat | lethal concentration (50 percent kill): 183 ppm/7H | VCVGH* -,605,1990 | |
oral/Dog | lowest published lethal dose: 10 gm/kg | Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea | ZEPTAT 1,446,1905 |
oral/guinea pig | lethal dose (50 percent kill): 487 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | ZDTUAB 27(5),9,1983 |
oral/mammal (species unspecified) | lowest published lethal dose: 1 gm/kg | HBAMAK 4,1289,1935 | |
oral/mouse | lethal dose (50 percent kill): 470 mg/kg | GISAAA 52(11),74,1987 | |
oral/rabbit | lethal dose (50 percent kill): 450 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | ZDTUAB 27(5),9,1983 |
oral/rat | lethal dose (50 percent kill): 355 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | ZDTUAB 27(5),9,1983 |
skin/rat | lethal dose (50 percent kill): 1184 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | ZDTUAB 27(5),9,1983 |
subcutaneous/mammal (species unspecified) | lowest published lethal dose: 1500 mg/kg | HBAMAK 4,1289,1935 | |
subcutaneous/mouse | lethal dose (50 percent kill): 630 mg/kg | Behavioral: Antipsychotic Vascular: Other changes Lung, Thorax, or Respiration: Other changes | TXAPA9 4,354,1962 |
subcutaneous/rabbit | lowest published lethal dose: 500 mg/kg | ZEPTAT 1,446,1905 | |
unreported route/frog | lowest published lethal dose: 606 mg/kg | ZEPTAT 1,446,1905 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 875 mg/kg/35D- intermittent | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | GISAAA 52(11),74,1987 |
oral/rat | lowest published toxic dose: 2166 mg/kg/61D- intermittent | Liver: Other changes | ZDTUAB 27(5),9,1983 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.6 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 636,242,2007 | |
TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODOFORM-air | 10H time-weighted average 0.6 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 84474; Number of Industries 4; Total Number of Facilities 510; Number of Occupations 12; Total Number of Employees Exposed 22584; Total Number of Female Employees Exposed 20381 | |
National Occupational Hazard Survey 1974 | Hazard Code 84474; Number of Industries 2; Total Number of Facilities 390; Number of Occupations 5; Total Number of Employees Exposed 1882 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat | NCITR* NCI-TR-110,1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health