Methane, tetranitro-
RTECS #
PB4025000
CAS #
Updated
December 2018
Molecular Weight
196.05
Molecular Formula
CN4O8
Synonyms
NCI-C55947
RCRA waste number P112
Tetan
Tetranitromethane
Tetranitromethane (ACGIH:OSHA)
TNM
RCRA waste number P112
Tetan
Tetranitromethane
Tetranitromethane (ACGIH:OSHA)
TNM
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | ovary/hamster | 20 mg/L | NTPTR* NTP-TR-386,1990 |
DNA Damage | lung/rat | 3.9 µmol/L/20H | MUREAV 605,94,2006 |
DNA Damage | lung/human | 1.95 µmol/L/20H | MUREAV 605,94,2006 |
DNA Damage | oral/rat | 65 mg/kg | MUREAV 605,94,2006 |
DNA Damage | liver/rat | 50 µmol/L/3H | MUREAV 629,49,2007 |
DNA Damage | liver/rat | 70 µmol/L | MUREAV 368,59,1996 |
mutation in microorganisms | /Salmonella typhimurium | 2 µg/plate (+enzymatic activation step) | ENMUDM 9(Suppl 9),1,1987 |
mutation in microorganisms | /Escherichia coli | 500 µg/plate (+enzymatic activation step) | SAIGBL 29,34,1987 |
sister chromatid exchange | ovary/hamster | 1700 µg/L | NTPTR* NTP-TR-386,1990 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 500 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma | NTPTR* NTP-TR-386,1990 |
inhalation/mouse | toxic concentration: 500 ppb/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma | CALEDQ 57,95,1991 |
inhalation/mouse | lowest published toxic concentration: 30.9 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB91-113373 |
inhalation/rat | lowest published toxic concentration: 2 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma | NTPTR* NTP-TR-386,1990 |
inhalation/rat | lowest published toxic concentration: 61.8 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB91-113373 |
inhalation/rat | lowest published toxic concentration: 51.5 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB91-113373 |
inhalation/rat | toxic concentration: 2 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma | CALEDQ 57,95,1991 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | lethal concentration (50 percent kill): 100 ppm/20M | 85JCAE -,403,1986 | |
inhalation/human | lowest published toxic concentration: 0.05 gm/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 4,134,1962 |
inhalation/mouse | Lowest published lethal concentration: 0.2 gm/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 4,134,1962 |
inhalation/mouse | lethal concentration (50 percent kill): 54.4 ppm | ENTOX* -,159,2005 | |
inhalation/mouse | lowest published toxic concentration: 0.1 gm/m3 | Vascular: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Acute pulmonary edema | TPKVAL 4,134,1962 |
inhalation/mouse | lethal concentration (50 percent kill): 54 ppm/4H | Blood: Methemoglobinemia- Carboxhemoglobinemia | NTIS** AD-A051-334 |
inhalation/mouse | lethal concentration (50 percent kill): 0.6 gm/m3 | TPKVAL 4,134,1962 | |
inhalation/rabbit | lowest published toxic concentration: 0.1 gm/m3 | Behavioral: Tetany | TPKVAL 4,134,1962 |
inhalation/rabbit | Lowest published lethal concentration: 0.2 gm/m3 | Brain and Coverings: Changes in circulation Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Recording from peripheral motor nerve | TPKVAL 4,134,1962 |
inhalation/rat | lowest published toxic concentration: 0.1 gm/m3 | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TPKVAL 4,134,1962 |
inhalation/rat | Lowest published lethal concentration: 0.2 gm/m3 | Brain and Coverings: Other degenerative changes | TPKVAL 4,134,1962 |
inhalation/rat | lethal concentration (50 percent kill): 18 ppm/4H | Blood: Methemoglobinemia- Carboxhemoglobinemia | AMRL** TR-77-25,1977 |
inhalation/rat | lethal concentration (50 percent kill): 17.5 ppm | ENTOX* -,159,2005 | |
inhalation/rat | Lowest published lethal concentration: 1.5 gm/m3 | Brain and Coverings: Changes in circulation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema | TPKVAL 4,167,1962 |
inhalation/rat | Lowest published lethal concentration: 0.6 gm/m3/2H | TPKVAL 4,134,1962 | |
intraperitoneal/mammal (species unspecified) | lowest published lethal dose: 500 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | COREAF 171,1396,1920 |
intraperitoneal/mouse | lethal dose (50 percent kill): 53 mg/kg | KHFZAN 10(6),53,1976 | |
intravenous/mouse | lethal dose (50 percent kill): 63100 µg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | AMRL** TR-77-25,1977 |
intravenous/rat | lethal dose (50 percent kill): 12600 µg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | AMRL** TR-77-25,1977 |
oral/mouse | lethal dose (50 percent kill): 375 mg/kg | Olfaction: Other olfaction effects Eye: Other eye effects Behavioral: Somnolence (general depressed activity) | NTIS** AD-A051-334 |
oral/mouse | lethal dose (50 percent kill): 375 mg/kg | ENTOX* -,159,2005 | |
oral/rat | lethal dose (50 percent kill): 130 mg/kg | Olfaction: Other olfaction effects Eye: Other eye effects Behavioral: Somnolence (general depressed activity) | NTIS** AD-A051-334 |
oral/rat | lethal dose (50 percent kill): 130 mg/kg | ENTOX* -,159,2005 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 25 ppm/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-386,1990 |
inhalation/mouse | lowest published toxic concentration: 10 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight | NTPTR* NTP-TR-386,1990 |
inhalation/rat | lowest published toxic concentration: 0.002 gm/m3/7D- intermittent | Behavioral: Alteration of classical conditioning | TPKVAL 4,134,1962 |
inhalation/rat | lowest published toxic concentration: 6350 ppb/6H/26W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHBC 10,213,1954 |
inhalation/rat | lowest published toxic concentration: 25 ppm/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-386,1990 |
inhalation/rat | lowest published toxic concentration: 10 ppm/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-386,1990 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.005 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 65,437,1996 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 65,437,1996 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 65,437,1996 |
TOXICOLOGY REVIEW | ENTOX* -,159,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 ppm (8 mg/m3) | DTLVS* 3,254,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 ppm (8 mg/m3), JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.005 ppm (0.04 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.005 ppm (0.04 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.05 ppm (0.41 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 1 ppm (8 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.005 ppm (0.04 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 1 ppm (8 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 1 ppm (8 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 ppm (8 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0,005 ppm (0,04 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.04 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.3 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.05 ppm (0.4 mg/m3);short term exposure limit 0.1 ppm (0.8 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (8 mg/m3), carc 2, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.04 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 ppm (8 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (8 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 ppm (8 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 ppm (8 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 ppm (8 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 ppm (8 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRANITROMETHANE-air | 10H time-weighted average 1 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X7237; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1445; Total Number of Female Employees Exposed 230 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health