Methane, nitro-
RTECS #
PA9800000
CAS #
Updated
March 2018
Molecular Weight
61.05
Molecular Formula
CH3NO2
Synonyms
Nitrocarbol
Nitrometan (Polish)
Nitromethane
Nitromethane (ACGIH:OSHA)
Nitrometan (Polish)
Nitromethane
Nitromethane (ACGIH:OSHA)
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 750 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Eye: Tumors Liver: Tumors | NTPTR* NTP-TR-461,1997 |
inhalation/mouse | lowest published toxic concentration: 46350 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Endocrine: Tumors | NTIS** PB97-205967 |
inhalation/mouse | lowest published toxic concentration: 23175 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Endocrine: Tumors | NTIS** PB97-205967 |
inhalation/rat | lowest published toxic concentration: 9656.25 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTIS** PB97-205967 |
inhalation/rat | lowest published toxic concentration: 188 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors | NTPTR* NTP-TR-461,1997 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | Lowest published lethal concentration: 5000 ppm/3H | JIHTAB 22,315,1940 | |
inhalation/monkey | Lowest published lethal concentration: 1000 ppm | INMEAF 16,441,1947 | |
inhalation/mouse | Lowest published lethal concentration: 18 gm/m3/2H | 85GMAT -,93,1982 | |
inhalation/rabbit | Lowest published lethal concentration: 5000 ppm/6H | JIHTAB 22,315,1940 | |
inhalation/rat | Lowest published lethal concentration: 12750 mg/m3/1H | NTIS** OTS0516767 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 110 mg/kg | KHFZAN 10(6),53,1976 | |
intraperitoneal/rat | lowest published lethal dose: 1500 mg/kg | BSPLA9 (1),29,1973 | |
intravenous/Dog | lowest published lethal dose: 800 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Lung, Thorax, or Respiration: Respiratory depression | AMIHAB 11,102,1955 |
intravenous/rabbit | lowest published lethal dose: 750 mg/kg | AMIHAB 11,102,1955 | |
oral/Dog | lowest published lethal dose: 125 mg/kg | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Liver: Hepatitis (hepatocellular necrosis), zonal | AMIHAB 11,102,1955 |
oral/mouse | lethal dose (50 percent kill): 950 mg/kg | GISAAA 32(9),9,1967 | |
oral/rabbit | lowest published lethal dose: 750 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | JIHTAB 22,315,1940 |
oral/rat | lethal dose (50 percent kill): 940 mg/kg | GISAAA 32(9),9,1967 | |
skin/rabbit | Lethal dose: >2 gm/kg | NTIS** OTS0516767 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 1500 ppm/6H/16D- intermittent | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory stimulation Liver: Changes in liver weight | NTPTR* NTP-TR-461,1997 |
inhalation/mouse | lowest published toxic concentration: 188 ppm/6H/13W- intermittent | Olfaction: Deviated nasal septum Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight | NTPTR* NTP-TR-461,1997 |
inhalation/rat | lowest published toxic concentration: 100 ppm/7H/2Y- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0530024 |
inhalation/rat | lowest published toxic concentration: 375 ppm/6H/16D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Olfaction: Deviated nasal septum | NTPTR* NTP-TR-461,1997 |
inhalation/rat | lowest published toxic concentration: 1500 ppm/6H/13W- intermittent | Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-461,1997 |
oral/rabbit | lowest published toxic dose: 2275 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 32(9),9,1967 |
oral/rat | lowest published toxic dose: 2275 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 32(9),9,1967 |
oral/rat | lowest published toxic dose: 10500 µL/kg/15W- continuous | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 11,102,1955 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 77,564,2000 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | ENTOX* -,247,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 566,49,2004 | |
TOXICOLOGY REVIEW | MUREAV 682,94,2009 | |
TOXICOLOGY REVIEW | TOLED5 204,148,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (250 mg/m3) | DTLVS* 3,187,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 20 ppm (50 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 100 ppm (250 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 20 ppm (51 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 20 ppm (50 mg/m3), carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 20 ppm (51 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 100 ppm (250 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 20 ppm (50 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 100 ppm (250 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (250 mg/m3);short term exposure limit 150 ppm (375 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 20 ppm (50 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 50 ppm (125 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 20 ppm (50 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 30 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 20 ppm (50 mg/m3);short term exposure limit 50 ppm (130 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 100 ppm (250 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 50 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (250 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (250 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 100 ppm (254 mg/m3);short term exposure limit 150 ppm (381 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health