Methane, bromochloro-

RTECS #

PA5250000

CAS #

74-97-5; 83847-49-8
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

129.39

Molecular Formula

CH₂BrCl

Synonyms

Bromochloromethane
Chlorobromomethane
Chlorobromomethane (ACGIH:OSHA)
Fluorocarbon 1011
Halon 1011
Methylene chlorobromide
Mil-B-4394-B
Monochloromonobromomethane
Mono-chloro-mono-bromo-methane

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	1 µmol/L	TECSDY 13,205,1987
mutation in microorganisms	/Salmonella typhimurium	10 mg/plate (+enzymatic activation step)	DHEFDK FDA-78-1046,1978
mutation in microorganisms	/Salmonella typhimurium	10 µg/plate (-enzymatic activation step)	TECSDY 13,205,1987
sister chromatid exchange	lung/hamster	5 µmol/L	TECSDY 13,205,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 12030 mg/m³/7H	Behavioral: General anesthetic Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea	JIHTAB 29,382,1947
inhalation/rat	Lowest published lethal concentration: 28800 ppm/15M	Behavioral: General anesthetic Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor	MRLR** #113,1952
inhalation/rat	lowest published toxic concentration: 7800 mg/m³/3H	Behavioral: General anesthetic	VCVGH* -,627,1990
inhalation/rat	Lowest published lethal concentration: 53000 mg/m³/15M		VCVGH* -,627,1990
oral/mouse	lethal dose (50 percent kill): 4300 mg/kg	Behavioral: General anesthetic	JIHTAB 29,382,1947
oral/rat	lethal dose (50 percent kill): 5 gm/kg		34ZIAG -,390,1969
skin/rabbit	lethal dose (50 percent kill): >20 gm/kg		NTIS** AD-A062-138

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 500 ppm/6H/26W- intermittent	Nutritional and Gross Metabolic: Changes in: Other metals	JOCMA7 8,251,1966
inhalation/rabbit	lowest published toxic concentration: 1000 ppm/7H/16W- intermittent	Nutritional and Gross Metabolic: Changes in: Other metals	AIHAAP 21,275,1960
inhalation/rat	lowest published toxic concentration: 1000 ppm/7H/16W- intermittent	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Changes in: Other metals	AIHAAP 21,275,1960
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/26W- intermittent	Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Changes in: Other metals	JOCMA7 8,251,1966

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 200 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 636,242,2007

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 200 ppm (1050 mg/m³)	DTLVS* 3,50,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (1060 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 200 ppm (1050 mg/m³);KZW 800 ppm (4200 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm (1075 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 200 ppm (1050 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 200 ppm (1100 mg/m³), short term exposure limit 250 ppm (1300 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 200 ppm (1050 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 200 ppm (1050 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 200 ppm (1050 mg/m³), short term exposure limit 250 ppm (1300 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 200 ppm (1050 mg/m³);short term exposure limit 250 ppm (1300 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (1060 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 100 ppm (525 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 200 ppm (1058 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 1000 mg/m³, short term exposure limit 1300 mg/m³, JAN1999
Occupational Exposure Limit-SWITZERLAND	MAK-week 200 ppm (1050 mg/m³), KZG-week 400 ppm (2100 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1050 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 200 ppm (1050 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 200 ppm (1050 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 200 ppm (1050 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 200 ppm (1050 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 200 ppm (1050 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROBROMOMETHANE-air	10H time-weighted average 200 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 18250; Number of Industries 1; Total Number of Facilities 35; Number of Occupations 1; Total Number of Employees Exposed 71
National Occupational Hazard Survey 1974	Hazard Code 18250; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 56

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health