Manganese
RTECS #
OO9275000
CAS #
Updated
September 2018
Molecular Weight
54.94
Molecular Formula
Mn
Synonyms
Colloidal manganese
Magnacat
Mangan (Polish)
Mangan nitridovany (Czech)
Manganese (ACGIH:OSHA)
Tronamang
Magnacat
Mangan (Polish)
Mangan nitridovany (Czech)
Manganese (ACGIH:OSHA)
Tronamang
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 500 mg/24H | mild | 28ZPAK -,21,1972 |
skin /rabbit | 500 mg/24H | mild | 28ZPAK -,21,1972 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Dominant Lethal Test | intraperitoneal/rat | 25 mg/kg | VCVN5* -,413,1989 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 0.71 mg/m3 (15-16D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | NRTXDN 27,395,2006 |
inhalation/rat | 0.71 mg/m3 (multigeneration) | Reproductive: Effects on newborn: Biochemical and metabolic | NRTXDN 27,395,2006 |
oral/rat | 90 mg/kg (18D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | TOSCF2 92,516,2006 |
oral/rat | 50 mg/kg (20D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NRTXDN 23,635,2002 |
oral/mouse | 322.5 mg/kg (43D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | REPTED 17,547,2003 |
oral/mouse | 1290 mg/kg (43D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 17,547,2003 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intramuscular/rat | lowest published toxic dose: 400 mg/kg/1Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application | NCIUS* PH43-64-886 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/man | lowest published toxic concentration: 2300 µg/m3 | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Behavioral: Muscle weakness | AIHAAP 27,454,1966 |
oral/rat | lethal dose (50 percent kill): 9 gm/kg | 28ZPAK -,21,1972 | |
Tank with water/Daphnia | lethal concentration (50 percent kill): 5700 µg/L/48H | TIVIEQ 31,125,1995 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/human | lowest published toxic concentration: 250 mg/m3/1Y- intermittent | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Irritability Lung, Thorax, or Respiration: Other changes | VCVN5* -,413,1989 |
inhalation/human | lowest published toxic concentration: 0.5 mg/m3/39W- intermittent | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Irritability | VCVN5* -,413,1989 |
inhalation/human | lowest published toxic dose: >0.1 mg/kg/1Y- intermittent | Behavioral: Change in motor activity (specific assay) | TOXID9 -,144,2008 |
inhalation/man | lowest published toxic concentration: 210 µg/m3/5Y- intermittent | Endocrine: Other changes | ACLSCP 26,10,1996 |
inhalation/monkey | lowest published toxic concentration: 0.3 mg/m3/5H/26W- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,412,1989 |
inhalation/mouse | lowest published toxic concentration: 0.7 mg/m3/24H/22W- continuous | Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,412,1989 |
inhalation/rat | lowest published toxic concentration: 0.71 mg/m3/2H/10D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other proteins | NRTXDN 27,395,2006 |
inhalation/rat | lowest published toxic concentration: 0.7 mg/m3/24H/22W- continuous | Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,412,1989 |
inhalation/rat | lowest published toxic concentration: 0.3 mg/m3/5H/26W- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,412,1989 |
inhalation/rat | lowest published toxic concentration: 3709 mg/m3/6H/13W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Other changes | TOXID9 54,85,2000 |
intraperitoneal/rat | lowest published toxic dose: 180 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Other metals | TOLED5 7,217,1981 |
intraperitoneal/rat | lowest published toxic dose: 57.6 mg/kg/4W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests | TOXID9 66,205,2002 |
intraperitoneal/rat | lowest published toxic dose: 216 mg/kg/15W- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOXID9 44,122,2005 |
intraperitoneal/rat | lowest published toxic dose: 144 mg/kg/5W- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOXID9 44,122,2005 |
oral/child | lowest published toxic dose: 8294 µg/kg/12Y- continuous | Brain and Coverings: Other degenerative changes | NRTXDN 53,124,2016 |
oral/rat | lowest published toxic dose: 5.25 mg/kg/21D- intermittent | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NETEEC 28,323,2006 |
oral/rat | lowest published toxic dose: 185 mg/kg/37D- continuous | Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | TOSCF2 92,516,2006 |
oral/rat | lowest published toxic dose: 200 mg/kg/20D- intermittent | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NRTXDN 23,645,2002 |
unreported route/rat | lowest published toxic dose: 24 mg/kg/5W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Ataxia Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) | TOXID9 78,82,2004 |
unreported route/rat | lowest published toxic dose: 72 mg/kg/5W- intermittent | Behavioral: Change in motor activity (specific assay) | TOXID9 78,82,2004 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.02 mg/m3 (resp),0.1 mg/m3 (inhal) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | TRBMAV 33,85,1975 | |
TOXICOLOGY REVIEW | ACLSCP 4,487,1974 | |
TOXICOLOGY REVIEW | ADTEAS 5,51,1972 | |
TOXICOLOGY REVIEW | FOREAE 7,313,1942 | |
TOXICOLOGY REVIEW | KOTTAM 11,1300,1975 | |
TOXICOLOGY REVIEW | 85DHAX Mn,1,1973 | |
TOXICOLOGY REVIEW | PEXTAR 12,102,1969 | |
TOXICOLOGY REVIEW | IMSUAI 24,1,1955 | |
TOXICOLOGY REVIEW | CREOH* 42,25,2002 | |
TOXICOLOGY REVIEW | BCPCA6 66,1,2003 | |
TOXICOLOGY REVIEW | TOLED5 134,17,2002 | |
TOXICOLOGY REVIEW | MUREAV 613,103,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,147,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,304,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,315,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,333,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,340,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,347,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,350,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,362,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,369,2006 | |
TOXICOLOGY REVIEW | NRTXDN 27,429,2006 | |
TOXICOLOGY REVIEW | MUREAV 613,76,2006 | |
TOXICOLOGY REVIEW | REPTED 23,260,2007 | |
TOXICOLOGY REVIEW | ITODC* -,355,2004 | |
TOXICOLOGY REVIEW | HUTOX* -,515,1996 | |
TOXICOLOGY REVIEW | HTOPA* 1,595,2002 | |
TOXICOLOGY REVIEW | MUREAV 674,73,2009 | |
TOXICOLOGY REVIEW | MUREAV 674,137,2009 | |
TOXICOLOGY REVIEW | PTPAD4 113,229,2007 | |
TOXICOLOGY REVIEW | MUREAV 667,82,2009 | |
TOXICOLOGY REVIEW | NEUCL* 23,485,2005 | |
TOXICOLOGY REVIEW | NETEEC 32,16,2010 | |
TOXICOLOGY REVIEW | NTAPM* -,265,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,617,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,689,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,711,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,727,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,753,1995 | |
TOXICOLOGY REVIEW | NBREV* 15,333,1991 | |
TOXICOLOGY REVIEW | NRTXDN 31,555,2010 | |
TOXICOLOGY REVIEW | NRTXDN 33,178,2012 | |
TOXICOLOGY REVIEW | REPTED 34,298,2012 | |
TOXICOLOGY REVIEW | NRTXDN 43,36,2014 | |
TOXICOLOGY REVIEW | NRTXDN 44,314,2014 | |
TOXICOLOGY REVIEW | TXCYAC 313,3,2013 | |
TOXICOLOGY REVIEW | TXCYAC 323,78,2014 | |
TOXICOLOGY REVIEW | MUREAV 770,140,2016 | |
TOXICOLOGY REVIEW | NETEEC 52,25,2015 | |
TOXICOLOGY REVIEW | MUREAV 770,170,2016 | |
TOXICOLOGY REVIEW | NRTXDN 56,262,2016 | |
TOXICOLOGY REVIEW | TOLED5 272,8,2017 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 5 mg/m3 | DTLVS* 3,149,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 mg/m3, JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 mg/m3 (dust), JUL2008 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg(Mn)/m3 (fume), MAY2011 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg/m3 (dust), MAY2011 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3 (respirable), MAY2011 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.2 mg/m3, inhal. dust, NOV2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, resp. dust, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 1 mg/m3 (fume), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 1 mg/m3 (resp. dust), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.2 mg/m3, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), 2006 | |
Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3 (dust), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg(Mn)/m3, 2004 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg/m3, 2004 | |
Occupational Exposure Limit-MEXICO | time-weighted average 1 mg(Mn)/m3 (fume), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 mg/m3 (dust), JAN2002 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 mg/m3; short term exposure limit 3 mg/m3 (fume), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 1 mg/m3, JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,2 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg/m3, short term exposure limit 0.6 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.2 mg/m3, (total dust);time-weighted average 0.1 mg/m3, (resp. dust), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 mg/m3, inhal, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 5 mg/m3, JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 mg/m3, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 5 mg/m3 (fume), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 mg/m3, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 5 mg(Mn)/m3, fume | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 5 mg(Mn)/m3, fume | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 5 mg(Mn)/m3, fume | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 5 mg(Mn)/m3, fume | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MANGANESE COMPDS (as Mn)-air | time-weighted average 1 mg/m3;short term exposure limit 3 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X5920; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 305; Total Number of Female Employees Exposed 71 | |
National Occupational Exposure Survey 1983 | Hazard Code X5992; Number of Industries 9; Total Number of Facilities 235; Number of Occupations 9; Total Number of Employees Exposed 4560; Total Number of Female Employees Exposed 12 | |
National Occupational Exposure Survey 1983 | Hazard Code 44000; Number of Industries 316; Total Number of Facilities 66404; Number of Occupations 125; Total Number of Employees Exposed 756403; Total Number of Female Employees Exposed 15912 | |
National Occupational Hazard Survey 1974 | Hazard Code 44000; Number of Industries 29; Total Number of Facilities 1963; Number of Occupations 53; Total Number of Employees Exposed 19787 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health