Malononitrile, o-chlorobenzylidene-
RTECS #
OO3675000
CAS #
Updated
December 2014
Molecular Weight
188.62
Molecular Formula
C10H5ClN2
Synonyms
(o-Chlorobenzal)malononitrile
2-Chlorobenzalmalononitrile
2-Chlorobenzylidene malononitrile
2-Chlorobmn
beta,beta-Dicyano-o-chlorostyrene
CS
NCI-C55118
o-Chlorobenzalmalononitrile
o-Chlorobenzylidene malonitrile
o-Chlorobenzylidene malononitrile
o-Chlorobenzylidene malononitrile (ACGIH:OSHA)
Propanedinitrile, ((2-chlorophenyl)methylene)
TL 238
USAF KF-11
2-Chlorobenzalmalononitrile
2-Chlorobenzylidene malononitrile
2-Chlorobmn
beta,beta-Dicyano-o-chlorostyrene
CS
NCI-C55118
o-Chlorobenzalmalononitrile
o-Chlorobenzylidene malonitrile
o-Chlorobenzylidene malononitrile
o-Chlorobenzylidene malononitrile (ACGIH:OSHA)
Propanedinitrile, ((2-chlorophenyl)methylene)
TL 238
USAF KF-11
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /guinea pig | 429 ng | APTOA6 35,412,1974 | |
eye /man | 0.005 ppm/20S | severe | MMEDA9 134,219,1969 |
eye /man | 624 ng | APTOA6 35,412,1974 | |
eye /rabbit | 5 mg | TXAPA9 4,656,1962 | |
eye /rabbit | 1 mg | mild | TXAPA9 17,295,1970 |
eye /rabbit | 1150 ng | APTOA6 35,412,1974 | |
skin /guinea pig | 12%/6H open irritation test | mild | ARTODN 40,75,1978 |
skin /human | 10 mg/1H | mild | BJDEAZ 90,657,1974 |
skin /rabbit | 12%/6H open irritation test | mild | ARTODN 40,75,1978 |
skin /rat | 12%/6H open irritation test | mild | ARTODN 40,75,1978 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | ovary/hamster | 6 mg/L | NTPTR* NTP-TR-377,1990 |
Cytogenetic Analysis | lung/hamster | 9400 nmol/L | MUREAV 282,231,1992 |
micronucleus test | lung/hamster | 19 µmol/L | ARTODN 63,314,1989 |
mutation in mammalian somatic cells | lymphocyte/mouse | 2500 µg/L | EMMUEG 11,91,1988 |
mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (+/-enzymatic activation step) | ARTODN 49,15,1981 |
sister chromatid exchange | ovary/hamster | 10 mg/L | NTPTR* NTP-TR-377,1990 |
sister chromatid exchange | lung/hamster | 18800 nmol/L | MUREAV 282,231,1992 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 6 mg/m3/5M (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | 37QLAZ -,79,1977 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/Dog | Lowest published lethal concentration: 2600 mg/m3/23M | Lung, Thorax, or Respiration: Other changes | FEPRA7 30(1),86,1971 |
inhalation/guinea pig | Lowest published lethal concentration: 2326 mg/m3/10M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation/human | lowest published toxic concentration: 1500 µg/m3/90M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes | AEHLAU 6,366,1963 |
inhalation/mouse | Lowest published lethal concentration: 2753 mg/m3/20M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation/rabbit | Lowest published lethal concentration: 1802 mg/m3/10M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation/rat | Lowest published lethal concentration: 1806 mg/m3/45M | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
intraperitoneal/guinea pig | lethal dose (50 percent kill): 73 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
intraperitoneal/mouse | lethal dose (50 percent kill): 32320 µg/kg | Immunological Including Allergic: Decrease in humoral immune response | TOLED5 8,73,1981 |
intraperitoneal/rabbit | lethal dose (50 percent kill): 32065 µg/kg | Blood: Other changes | TOXID9 3,64,1983 |
intraperitoneal/rat | lethal dose (50 percent kill): 48 mg/kg | TXAPA9 24,45,1973 | |
intravenous/mouse | lethal dose (50 percent kill): 48 mg/kg | ENTOX* ,706,2005 | |
intravenous/mouse | lethal dose (50 percent kill): 47700 µg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes | TXAPA9 25,111,1973 |
intravenous/rabbit | lethal dose (50 percent kill): 8 mg/kg | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea | TXAPA9 4,656,1962 |
intravenous/rat | lethal dose (50 percent kill): 28 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
oral/guinea pig | lethal dose (50 percent kill): 212 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
oral/mouse | lethal dose (50 percent kill): 282 mg/kg | NTIS** AD837-111 | |
oral/rabbit | lethal dose (50 percent kill): 143 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
oral/rat | lethal dose (50 percent kill): 178 mg/kg | Gastrointestinal: Gastritis | AEHLAU 24,449,1972 |
subcutaneous/mouse | Lethal dose: >800 mg/kg | TXAPA9 4,656,1962 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 10 mg/m3/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-377,1990 |
inhalation/mouse | lowest published toxic concentration: 3 mg/m3/6H/13W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-377,1990 |
inhalation/rat | lowest published toxic concentration: 100 mg/m3/6H/14D- intermittent | Eye: Lacrimation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-377,1990 |
inhalation/rat | lowest published toxic concentration: 1500 µg/m3/6H/13W- intermittent | Olfaction: Other olfaction effects Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-377,1990 |
intraperitoneal/mouse | lowest published toxic dose: 160 mg/kg/10D- intermittent | Liver: Changes in liver weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response | BECTA6 26,571,1981 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 0.05 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | CPEMM* 3,239,2002 | |
TOXICOLOGY REVIEW | ENTOX* -,686,2005 | |
TOXICOLOGY REVIEW | ENTOX* -,706,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HTCWA* 2,153, | |
TOXICOLOGY REVIEW | CCACL* 21,719,2005 | |
TOXICOLOGY REVIEW | NBREV* 5,1,1981 | |
TOXICOLOGY REVIEW | TOLED5 204,148,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.05 ppm (0.4 mg/m3) | DTLVS* 3,50,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | ceiling concentration 0.05 ppm (0.39 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.05 ppm (0.4 mg/m3);KZW 0.05 ppm (0.4 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 ppm (0.4 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | ceiling concentration 0.05 ppm (0.4 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FRANCE | short term exposure limit 0.05 ppm (0.4 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 0.05 ppm (0.4 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | ceiling concentration 0.05 ppm (0.4 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | peak 0.5 ppm (0.4 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 0.05 ppm (0.39 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.05 ppm (0.4 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | short term exposure limit 0.05 ppm (0.39 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.05 ppm (0.4 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-C 0.4 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 05 ppm (0.4 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.05 ppm (0.4 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.05 ppm (0.4 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.05 ppm (0.4 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.05 ppm (0.4 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROBENZYLIDENEMALONONITRILE-air | ceiling concentration 0.05 ppm (Sk) | NIOSH* DHHS #95-121,1995 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health