Isocyanic acid, methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester

RTECS #

NQ9370000

CAS #

4098-71-9
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

222.32

Molecular Formula

C₁₂H₁₈N₂O₂

Synonyms

3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate
Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl- (9CI)
IPDI
Isophorone diamine diisocyanate
Isophorone diisocyanate
Isophorone diisocyanate (ACGIH)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /mouse	1%/5D-continuous		NTPTR* IMM-90001.

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	415 mg/kg (8-12D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	WDZAEK 5,178,1991

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 103 gm/L/3H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 95 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 42 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 26 gm/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,174,2013
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): 7.6 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 1.2 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 1778.3 µmol/L/1H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 5128.6 µmol/L/1H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 851.1 µmol/L/1H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 2511.9 µmol/L/1H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TIVIEQ 32,347,2016
inhalation/guinea pig	lethal concentration (50 percent kill): 118 mg/m³/1H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0543418
inhalation/rat	lowest published toxic concentration: 7.5 mg/m³/6H	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Changes in lung weight	JAPTO* 24,231,2004
inhalation/rat	lowest published toxic concentration: 2.1 mg/m³/6H	Lung, Thorax, or Respiration: Other changes	JAPTO* 24,231,2004
inhalation/rat	lowest published toxic concentration: 7.5 mg/m³/6H	Nutritional and Gross Metabolic: Body temperature decrease	JAPTO* 24,231,2004
inhalation/rat	lethal concentration (50 percent kill): 123 mg/m³/4H		85INA8 5,334(86),1986
oral/cat	lethal dose (50 percent kill): 1 mL/kg		NTIS** OTS0528418
oral/mouse	lowest published lethal dose: 2500 µL/kg		NTIS** OTS0528418
oral/rat	lethal dose (50 percent kill): 4825 mg/kg		NTIS** OTS0530238
skin/rat	lowest published lethal dose: 1 mL/kg		NTIS** OTS0528418

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 7.5 mg/m³/3D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 261,103,2009
inhalation/rat	lowest published toxic concentration: 1370 µg/m³/4H/4W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0528418
skin/mouse	lowest published toxic dose: 220 mg/kg/12D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 207,487,2005
skin/mouse	lowest published toxic dose: 480 mg/kg/28D- intermittent	Immunological Including Allergic: Increase in humoral response	TOSCF2 94,108,2006
skin/mouse	lowest published toxic dose: 1 pph/3D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 261,103,2009

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 140-141,213,2003

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.02 mg(NCO)/m³, short term exposure limit 0.07 mg(NCO)/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.01 ppm (0.09 mg/m³);KZW 0.02 ppm (0.18 mg/m³), sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.005 ppm (0.046 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 ppm (0.045 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 0.01 ppm (0.09 mg/m³), VLE 0.02 ppm (0.18 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.005 ppm (0.046 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.005 ppm (0.05 mg/m³), short term exposure limit 0.01 ppm (0.09 mg/m³), skin, sen, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.005 ppm (0.045 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.01 ppm (0.09 mg/m³), 2004
Occupational Exposure Limit-NORWAY	time-weighted average 0.005 ppm (0.045 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,005 ppm (0,045 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 0.002 ppm (0.018 mg/m³), ceiling concentration 0.005 ppm (0.046 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.02 mg(NCO)/m³, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IPDI-air	10H time-weighted average 0.005 ppm (Sk);short term exposure limit 0.02 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 83571; Number of Industries 15; Total Number of Facilities 1186; Number of Occupations 16; Total Number of Employees Exposed 7245; Total Number of Female Employees Exposed 682
National Occupational Hazard Survey 1974	Hazard Code 83571; Number of Industries 4; Total Number of Facilities 111; Number of Occupations 19; Total Number of Employees Exposed 3441

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health