Isocyanic acid, methylenedi-4,1-cyclohexylene ester

RTECS #

NQ9250000

CAS #

5124-30-1
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

262.39

Molecular Formula

C₁₅H₂₂N₂O₂

Synonyms

4,4'-Diisocyanatodicyclohexylmethane
Bis(4-isocyanatocyclohexyl)methane
CP 99173
Cyclohexane, 1,1'-methylenebis(4-isocyanato- (9CI)
Dicyclohexylmethane-4,4'-diisocyanate
Hydrogenated MDI
Hylene W
Methylene bis-(4-cyclohexylisocyanate)
Methylene bis(4-cyclohexylisocyanate)
Methylene bis(4-cyclohexylisocyanate) (ACGIH)
Nacconate H 12

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL	mild	NTIS** OTS0530188
eye /rabbit	100 µL/24H	severe	NTIS** OTS0555173
skin /rabbit	500 µL/24H	moderate	NTIS** OTS0555173

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lethal concentration (50 percent kill): 51 mg/m³/1H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes	NTIS** OTS0534736
inhalation/rat	Lowest published lethal concentration: 431 mg/m³/4H		ARTODN 78,243,2004
inhalation/rat	Lowest published lethal concentration: 20 ppm/5H		85INA8 6,998,1991
oral/rat	lethal dose (50 percent kill): 9900 mg/kg	Behavioral: Food intake (animal) Gastrointestinal: Hypermotility, diarrhea Liver: Other changes	NTIS** OTS000555173
skin/rabbit	Lethal dose: >10 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Behavioral: Muscle weakness	NTIS** OTS0555173

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
skin/mouse	lowest published toxic dose: 220 mg/kg/12D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 207,487,2005
skin/mouse	lowest published toxic dose: 280 mg/kg/14D- intermittent	Immunological Including Allergic: Increase in humoral response	TOSCF2 94,108,2006
skin/mouse	lowest published toxic dose: 480 mg/kg/28D- intermittent	Lung, Thorax, or Respiration: Other changes	TOSCF2 94,108,2006

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 140-141,213,2003

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.005 ppm (0.054 mg/m³);KZW 0.005 ppm (0.054 mg/m³), skin, sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.005 ppm (0.055 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 ppm (0.054 mg/m³), MAY2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.005 ppm (0.054 mg/m³), NOV2011
Occupational Exposure Limit-MEXICO	time-weighted average 0.01 ppm (0.11 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.02 mg(NCO)/m³; short term exposure limit 0.07 mg(NCO)/m³, sen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.005 ppm (0.05 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,005 ppm (0,054 mg/m³), JUL2005
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 0.1 1 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE-air	ceiling concentration 0.01 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X1175; Number of Industries 16; Total Number of Facilities 624; Number of Occupations 18; Total Number of Employees Exposed 7764; Total Number of Female Employees Exposed 637
National Occupational Hazard Survey 1974	Hazard Code M1655; Number of Industries 6; Total Number of Facilities 102; Number of Occupations 22; Total Number of Employees Exposed 4022

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health