Iodine
RTECS #
NN1575000
CAS #
Updated
March 2019
Molecular Weight
253.80
Molecular Formula
I2
Synonyms
IODE (French)
Iodine (ACGIH:OSHA)
Iodine crystals
Iodine sublimed
Iodio (Italian)
Jod (German, Polish)
Jood (Dutch)
Iodine (ACGIH:OSHA)
Iodine crystals
Iodine sublimed
Iodio (Italian)
Jod (German, Polish)
Jood (Dutch)
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 1100 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | JONUAI 84,107,1964 |
oral/rat | 2750 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | JONUAI 84,107,1964 |
oral/rabbit | 15 mg/kg (30-31D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | JONUAI 87,394,1965 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/human | lowest published toxic concentration: 1 mg/m3 | Behavioral: Muscle weakness Behavioral: Coma Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,400,1989 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 100 mg/m3 | Endocrine: Other changes | VCVN5* -,399,1989 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 10 mg/m3 | Lung, Thorax, or Respiration: Cough | VCVN5* -,399,1989 |
inhalation/rat | lowest published toxic concentration: 100 mg/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | VCVN5* -,399,1989 |
inhalation/rat | Lowest published lethal concentration: 137 ppm/1H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Body temperature decrease | NTIS** OTS0555278 |
intravenous/Dog | lowest published lethal dose: 40 mg/kg | HBTXAC 5,76,1959 | |
oral/Dog | lowest published lethal dose: 800 mg/kg | HBAMAK 4,1289,1935 | |
oral/human | lowest published lethal dose: 28 mg/kg | Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Other changes | 34ZIAG -,330,1969 |
oral/human | lowest published toxic dose: 0.07 gm/kg | Behavioral: Muscle weakness Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Renal function tests depressed | VCVN5* -,400,1989 |
oral/human | lowest published toxic dose: 25 mg/kg | Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | VCVN5* -,400,1989 |
oral/mouse | lethal dose (50 percent kill): 1000 mg/kg | Behavioral: Change in motor activity (specific assay) | VCVN5* -,399,1989 |
oral/mouse | lethal dose (50 percent kill): 22 gm/kg | DRFUD4 4,876,1979 | |
oral/rabbit | lethal dose (50 percent kill): 10 gm/kg | DRFUD4 4,876,1979 | |
oral/rabbit | lowest published lethal dose: 5 mg/kg | Blood: Other hemolysis with or without anemia | VCVN5* -,399,1989 |
oral/rat | lethal dose (50 percent kill): 14 gm/kg | DRFUD4 4,876,1979 | |
oral/woman | lowest published toxic dose: 26 mg/kg/1Y- intermittent | Endocrine: Evidence of thyroid hyperfunction | PGMJAO 62,661,1986 |
subcutaneous/mouse | lethal dose (50 percent kill): >8650 mg/kg | NIIRDN -,1226,1990 | |
subcutaneous/rabbit | lowest published lethal dose: 175 mg/kg | HBTXAC 5,76,1959 | |
subcutaneous/rat | lethal dose (50 percent kill): 10500 mg/kg | NIIRDN -,1226,1990 | |
unreported route/man | lowest published lethal dose: 29 mg/kg | 85DCAI 2,73,1970 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mammal (species unspecified) | lowest published toxic concentration: 0.5 mg/m3/24H/8W- continuous | Olfaction: Change in sensation of smell | VCVN5* -,400,1989 |
inhalation/rat | lowest published toxic concentration: 3.1 mg/m3/24H/13W- continuous | Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed Endocrine: Other changes | VCVN5* -,400,1989 |
inhalation/rat | lowest published toxic concentration: 1.38 mg/m3/24H/13W- continuous | Behavioral: Change in motor activity (specific assay) Behavioral: Aggression | VCVN5* -,400,1989 |
oral/rat | lowest published toxic dose: 746 mg/kg/14W- continuous | Blood: Other changes | JTEHD6 32,89,1991 |
oral/woman | lowest published toxic dose: 864 mg/kg/26W- intermittent | Endocrine: Evidence of thyroid hyperfunction Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCLPH* 23(Suppl 1),103,2009 |
oral/woman | lowest published toxic dose: 378 µg/kg/18W- intermittent | Endocrine: Other changes | NETEEC 51,45,2015 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.01 ppm (inhal, vapor) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FOREAE 7,313,1942 | |
TOXICOLOGY REVIEW | KOTTAM 11,1300,1975 | |
TOXICOLOGY REVIEW | HUTOX* -,661,1996 | |
TOXICOLOGY REVIEW | HTOPA* 1,595,2002 | |
TOXICOLOGY REVIEW | SFDRA* 38,443,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,258,1998 |
Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 0.1 ppm (1 mg/m3) | DTLVS* 3,135,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | ceiling concentration 0.1 ppm (1 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (1 mg/m3);KZW 0.1 ppm (1 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (1 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | ceiling concentration 0.1 ppm (1 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 0.1 ppm (1.1 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VLE 0.1 ppm (1 mg/m3), FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 1 mg/m3, short term exposure limit 1 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 0.1 ppm (1 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (1 mg/m3), s2 sen, MAY2012 | |
Occupational Exposure Limit-KOREA | ceiling concentration 0.1 ppm (1 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | peak 0.1 ppm (1 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 0.1 ppm (1 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average short term exposure limit 0,1 ppm (1 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | ceiling concentration 0.1 ppm (1 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.1 ppm (1 mg/m3), sen, JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.1 ppm (1 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-C 1 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 ppm (1 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.1 ppm (1 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 0.1 ppm (1.1 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 0.1 ppm (1 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 0.1 ppm (1 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 0.1 ppm (1 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 0.1 ppm (1 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODINE-air | ceiling concentration 0.1 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 40030; Number of Industries 63; Total Number of Facilities 6179; Number of Occupations 77; Total Number of Employees Exposed 204902; Total Number of Female Employees Exposed 129889 | |
National Occupational Hazard Survey 1974 | Hazard Code 40030; Number of Industries 51; Total Number of Facilities 7490; Number of Occupations 46; Total Number of Employees Exposed 124917 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health