Hydrofluoric acid
RTECS #
MW7875000
CAS #
Updated
December 2018
Molecular Weight
20.01
Molecular Formula
FH
Synonyms
Acide fluorhydrique (French)
Acido fluoridrico (Italian)
Fluorowodor (Polish)
Fluorwasserstoff (German)
Fluorwaterstof (Dutch)
Hydrofluoride
Hydrogen fluoride
Hydrogen fluoride (ACGIH:OSHA)
RCRA waste number U134
Rubigine
Acido fluoridrico (Italian)
Fluorowodor (Polish)
Fluorwasserstoff (German)
Fluorwaterstof (Dutch)
Hydrofluoride
Hydrogen fluoride
Hydrogen fluoride (ACGIH:OSHA)
RCRA waste number U134
Rubigine
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /human | 50 mg | severe | AMLTAS 37,110,1957 |
skin /rat | 50%/3M | severe | JTCTDW 40,861,2002 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | inhalation/rat | 1 mg/m3/6H/24D- intermittent | CYGEDX 9(1),40,1975 |
DNA Damage | inhalation/Drosophila melanogaster | 1300 ppb/6W | ATENBP 5,117,1971 |
sex chromosome loss and nondisjunction | inhalation/Drosophila melanogaster | 2900 ppb | FLUOA4 4,25,1971 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 470 µg/m3/4H (1-22D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | GTPZAB 19(3),57,1975 |
inhalation/rat | 4980 µg/m3/4H (1-22D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | GTPZAB 19(3),57,1975 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, skin | Inhibitor Concentration Low: 5 pph/3M | In Vitro Toxicity Studies: Other assays | TOLED5 248,25,2016 |
In Vitro/Human, skin | Inhibitor Concentration Low: 30 pph/3M | In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TOLED5 248,25,2016 |
In Vitro/Human, skin | Inhibitor Concentration Low: 50 pph/10M | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TOLED5 248,25,2016 |
inhalation/guinea pig | Lowest published lethal concentration: 25 mg/m3/5H | VCVN5* -,349,1993 | |
inhalation/guinea pig | lethal concentration (50 percent kill): 4327 ppm | ENTOX* -,542,2005 | |
inhalation/guinea pig | lethal concentration (50 percent kill): 4327 ppm/15M | Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AIHAAP 24,253,1963 |
inhalation/guinea pig | Lowest published lethal concentration: 40 mg/m3/2H | VCVN5* -,349,1993 | |
inhalation/human | Lowest published lethal concentration: 50 ppm/30M | 34ZIAG -,318,1969 | |
inhalation/human | Lowest published lethal concentration: 200 mg/m3 | VCVN5* -,350,1993 | |
inhalation/human | lowest published toxic concentration: 25 mg/m3 | Lung, Thorax, or Respiration: Cough Eye: Conjunctiva irritation | VCVN5* -,350,1993 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 8 mg/m3 | Lung, Thorax, or Respiration: Cough | VCVN5* -,349,1993 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 0.03 mg/m3 | Eye: Other eye effects | VCVN5* -,349,1993 |
inhalation/man | lowest published toxic concentration: 100 mg/m3/1M | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | JIDHAN 16,129,1934 |
inhalation/monkey | lethal concentration (50 percent kill): 1774 ppm/1H | Behavioral: Coma Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Other changes | AMRL** TR-70-77,1970 |
inhalation/monkey | lethal concentration (50 percent kill): 1774 ppm | ENTOX* -,542,2005 | |
inhalation/mouse | Lowest published lethal concentration: 263 ppm/1H | TOXID9 78,149,2004 | |
inhalation/mouse | lethal concentration (50 percent kill): 342 ppm | ENTOX* -,542,2005 | |
inhalation/mouse | lethal concentration (50 percent kill): 342 ppm/1H | Eye: Corneal damage Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea | JCTODH 3,61,1976 |
inhalation/mouse | lethal concentration (50 percent kill): 5000 mg/m3/5M | VCVN5* -,349,1993 | |
inhalation/mouse | lethal concentration (50 percent kill): 270 mg/m3/60M | VCVN5* -,349,1993 | |
inhalation/rabbit | Lowest published lethal concentration: 40 mg/m3/2H | VCVN5* -,349,1993 | |
inhalation/rabbit | Lowest published lethal concentration: 260 mg/m3/7H | AMIHBC 2,716,1950 | |
inhalation/rabbit | Lowest published lethal concentration: 25 mg/m3/5H | VCVN5* -,349,1993 | |
inhalation/rat | lowest published toxic concentration: 148 mg/m3/6H | Olfaction: Other olfaction effects | VCVN5* -,349,1993 |
inhalation/rat | lethal concentration (50 percent kill): 1276 ppm | ENTOX* -,542,2005 | |
inhalation/rat | lethal concentration (50 percent kill): 1276 ppm/1H | Eye: Lacrimation Behavioral: Change in motor activity (specific assay) Gastrointestinal: Changes in structure or function of salivary glands | AIHAAP 33,661,1972 |
inhalation/rat | lethal concentration (50 percent kill): 1100 mg/m3/60M | VCVN5* -,349,1993 | |
intraperitoneal/rat | lowest published lethal dose: 25 mg/kg | TXAPA9 13,76,1968 | |
intraperitoneal/rat | lethal dose (50 percent kill): 25 mg/kg | ENTOX* -,542,2005 | |
intravenous/rat | lethal dose (50 percent kill): 17.4 mg/kg | TIHEEC 23,5,2007 | |
intravenous/rat | lowest published lethal dose: 13.1 mg/kg | TIHEEC 23,5,2007 | |
intravenous/rat | lowest published toxic dose: 3.2 mg/kg | Kidney, Ureter, and Bladder: Renal function tests depressed Nutritional and Gross Metabolic: Changes in: P | TIHEEC 23,5,2007 |
intravenous/rat | lowest published toxic dose: 6.4 mg/kg | Endocrine: Hyperglycemia Nutritional and Gross Metabolic: Changes in: Ca Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | TIHEEC 23,5,2007 |
intravenous/rat | lowest published toxic dose: 9.6 mg/kg | Endocrine: Hyperglycemia Nutritional and Gross Metabolic: Changes in: K Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | TIHEEC 23,5,2007 |
oral/man | lowest published toxic dose: 143 mg/kg | Cardiac: Arrythmias (indlucing changes in conduction) Vascular: BP lowering not characterized in autonomic section Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | JTCTDW 35,307,1997 |
skin/mouse | lowest published lethal dose: 500 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | SAIGBL 17,281,1975 |
subcutaneous/frog | lowest published lethal dose: 112 mg/kg | CRSBAW 124,133,1937 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 0.15 mg/m3/24H/78W- continuous | Musculoskeletal: Changes in teeth and supporting structures | VCVN5* -,350,1989 |
inhalation/rat | lowest published toxic concentration: 300 µg/m3/24H/22W- continuous | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 30(5),11,1965 |
inhalation/rat | lowest published toxic concentration: 252 µg/m3/6H/17W- intermittent | Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | GISAAA 41(5),6,1976 |
inhalation/rat | lowest published toxic concentration: 72 mg/m3/3H/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,349,1989 |
inhalation/rat | lowest published toxic concentration: 10 mg/m3/24H/4D- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVN5* -,349,1989 |
inhalation/rat | lowest published toxic concentration: 0.5 mg/m3/24H/17W- continuous | Musculoskeletal: Changes in teeth and supporting structures | VCVN5* -,350,1989 |
inhalation/rat | lowest published toxic concentration: 42.3 mg/m3/24H/6W- continuous | Musculoskeletal: Changes in teeth and supporting structures | VCVN5* -,350,1989 |
subcutaneous/rat | lowest published toxic dose: 364 mg/kg/26W- intermittent | Kidney, Ureter, and Bladder: Other changes Musculoskeletal: Changes in teeth and supporting structures Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FKIZA4 50,1397,1959 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-TVA 0.5 ppm;ceiling concentration 2 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg(F)/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | JEMME* 10,163,1992 | |
TOXICOLOGY REVIEW | AMSSAQ 400,5,1963 | |
TOXICOLOGY REVIEW | DIMON* 46,551,2000 | |
TOXICOLOGY REVIEW | ENTOX* -,542,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,683,1996 | |
TOXICOLOGY REVIEW | ISMEA* 10,381,2008 | |
TOXICOLOGY REVIEW | CCACL* 21,719,2005 | |
TOXICOLOGY REVIEW | REPTED 29,1,2010 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 3 ppm (2 mg/m3) | DTLVS* 3,131,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 2 ppm (2 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | ceiling concentration 3 ppm (2.6 mg(F)/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 1.8 ppm (1.5 mg/m3);KZW 3 ppm (2.5 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 1.8 ppm (1.5 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), MAR2002 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg(F)/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 1.8 ppm (1.5 mg/m3), MAY2011 | |
Occupational Exposure Limit-EC | time-weighted average 1.5 mg/m3 (1.8 ppm);short term exposure limit 2.5 mg/m3 (3 ppm), JUN2000 | |
Occupational Exposure Limit-FINLAND | time-weighted average 1.8 ppm (1.5 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 1.8 ppm (1.5 mg/m3), VLE 3 ppm (2.5 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 1 ppm (0.83 mg/m3), 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 1.5 mg/m3, short term exposure limit 2.5 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.7 ppm (0.6 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | ceiling concentration 3 ppm (2.5 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | ceiling concentration 3 ppm (2.5 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | peak 3 ppm (2.5 mg(F)/m3), 2004 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg(F)/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 3 ppm (2.6 mg(F)/m3), JAN2002 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg(F)/m3, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.8 ppm (0.6 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 1,8 ppm (1,5 mg/m3); short term exposure limit 3 ppm (2,5 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg(F)/m3, short term exposure limit 0.5 mg(F)/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | ceiling concentration 2 ppm (1.7 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (0.83 mg/m3), KZG-week 2 ppm (1.66 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 3 ppm (2 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 3 ppm (2 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 1.8 ppm (1.5 mg(F)/m3);short term exposure limit 3 ppm (2.5 mg(F)/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 3 ppm (2 mg(F)/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 3 ppm (2 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 3 ppm | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 3 ppm (2 mg(F)/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN FLUORIDE-air | 10H time-weighted average 3 ppm;short term exposure limit 6 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 38550; Number of Industries 96; Total Number of Facilities 11332; Number of Occupations 89; Total Number of Employees Exposed 189051; Total Number of Female Employees Exposed 68792 | |
National Occupational Hazard Survey 1974 | Hazard Code 38550; Number of Industries 97; Total Number of Facilities 6590; Number of Occupations 68; Total Number of Employees Exposed 68886 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health