Hydrazine, 1,1-dimethyl-
RTECS #
MV2450000
CAS #
Updated
June 2018
Molecular Weight
60.12
Molecular Formula
C2H8N2
Synonyms
1,1-Dimethylhydrazin (German)
1,1-Dimethylhydrazine
1,1-Dimethylhydrazine (ACGIH:OSHA)
as-Dimethyl hydrazine
asymmetric-Dimethylhydrazine
Dimazin
Dimazine
Dimethylhydrazine
N,N-Dimethylhydrazine
Niesymetryczna dwu metylohydrazyna (Polish)
RCRA waste number U098
uns-Dimethylhydrazine
Unsymmetrical dimethylhydrazine
1,1-Dimethylhydrazine
1,1-Dimethylhydrazine (ACGIH:OSHA)
as-Dimethyl hydrazine
asymmetric-Dimethylhydrazine
Dimazin
Dimazine
Dimethylhydrazine
N,N-Dimethylhydrazine
Niesymetryczna dwu metylohydrazyna (Polish)
RCRA waste number U098
uns-Dimethylhydrazine
Unsymmetrical dimethylhydrazine
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | subcutaneous/rat | 160 mg/kg/3W- intermittent | MUREAV 582,146,2005 |
Cytogenetic Analysis | inhalation/rat | 54 mg/kg/10D | MUREAV 577S,1,2005 |
DNA Damage | inhalation/rat | 100 gm/L/4H/30D- intermittent | TOVEFN -,11,2009 |
DNA Damage | oral/rat | 200 mg/kg | TOVEFN -,11,2009 |
DNA Damage | subcutaneous/rat | 160 mg/kg/3W- intermittent | MUREAV 582,146,2005 |
DNA Damage | /Escherichia coli | 1 µmol/L | ARTODN 46,277,1980 |
DNA Damage | fibroblast/human | 300 µmol/L | ENMUDM 7,267,1985 |
DNA Damage | liver/rat | 30 µmol/L | MUREAV 113,357,1983 |
DNA Damage | intraperitoneal/mouse | 3500 µmol/kg | CNREA8 41,1469,1981 |
DNA Damage | oral/mouse | 50 mg/kg | MUREAV 415,1,1998 |
DNA inhibition | oral/mouse | 200 mg/kg | MUREAV 46,305,1977 |
DNA inhibition | Ascites tumor/mouse | 1100 µmol/L | JJATDK 1,243,1981 |
DNA repair | /Bacillus subtilis | 6 mg/disc | MUREAV 97,1,1982 |
DNA repair | /Escherichia coli | 600 µg/disc | MUREAV 97,1,1982 |
DNA repair | liver/mouse | 100 µmol/L | JJCREP 79,204,1988 |
host-mediated assay | Salmonella typhimurium/mouse | 125 mg/kg | JJIND8 62,911,1979 |
micronucleus test | intraperitoneal/mouse | 28 mg/kg/24H-continuous | MUREAV 216,321,1989 |
morphological transform | other cell types/human | 50 mg/L | ITCSAF 17,719,1981 |
morphological transform | fibroblast/human | 167 µmol/L | PNASA6 80,7219,1983 |
morphological transform | oral/rat | 200 µmol/kg | CBINA8 43,313,1983 |
mutation in mammalian somatic cells | lymphocyte/mouse | 5 mmol/L/24H | NTIS** AD-A075-605 |
mutation in mammalian somatic cells | lung/hamster | 5 mmol/L | MUREAV 130,121,1984 |
mutation in microorganisms | /Aspergillus nidulans | 198 µg/plate (-enzymatic activation step) | MUREAV 80,265,1981 |
mutation in microorganisms | /Salmonella typhimurium | 42 µmol/plate (+enzymatic activation step) | CNREA8 41,1469,1981 |
mutation in microorganisms | /Salmonella typhimurium | 500 µg/plate (-enzymatic activation step) | CNJGA8 21,319,1979 |
mutation in microorganisms | /Escherichia coli | 20 µmol/L (-enzymatic activation step) | ARTODN 46,277,1980 |
other mutation test systems | Ascites tumor/mouse | 900 µmol/L | JJATDK 1,243,1981 |
phage inhibition capacity | /Escherichia coli | 17 gm/L | CNREA8 41,532,1981 |
sister chromatid exchange | intraperitoneal/mouse | 10 mg/kg | ENMUDM 8,579,1986 |
sperm morphology | intraperitoneal/mouse | 2300 mg/kg/5D-continuous | CMMUAO 5,257,1978 |
Unscheduled DNA Synthesis | intraperitoneal/rat | 60 mg/kg | CANCAR 36,2364,1975 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | 600 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JTEHD6 13,125,1984 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 144 mg/kg/8W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | JNCIAM 42,337,1969 |
oral/hamster | lowest published toxic dose: 228 gm/kg/48W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Vascular: Tumors Gastrointestinal: Colon tumors | CANCAR 40,2427,1977 |
oral/mouse | toxic dose: 288 mg/kg/8W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | JNCIAM 42,337,1969 |
oral/mouse | lowest published toxic dose: 5880 mg/kg/42W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Vascular: Tumors Lung, Thorax, or Respiration: Tumors | JNCIAM 50,181,1973 |
oral/rat | toxic dose: 300 mg/kg/14W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Ear: Tumors Gastrointestinal: Colon tumors | NATUAS 246,491,1973 |
oral/rat | lowest published toxic dose: 150 mg/kg/7W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Ear: Tumors Gastrointestinal: Colon tumors | NATUAS 246,491,1973 |
subcutaneous/hamster | lowest published toxic dose: 2686 mg/kg/72W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Peripheral Nerve and Sensation: Peripheral nerve tumors | CALEDQ 35,303,1987 |
subcutaneous/mouse | lowest published toxic dose: 420 mg/kg/21W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Colon tumors | CALEDQ 39,69,1988 |
subcutaneous/mouse | toxic dose: 200 mg/kg/25W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | BEXBAN 92,1681,1981 |
subcutaneous/rat | lowest published toxic dose: 21 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Gastrointestinal: Colon tumors | SUFOAX 31,413,1980 |
subcutaneous/rat | toxic dose: 400 mg/kg/20W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Gastrointestinal: Colon tumors | SUFOAX 31,413,1980 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/Dog | lethal concentration (50 percent kill): 3580 ppm/15M | Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | AIHAAP 24,137,1963 |
inhalation/Dog | lowest published toxic concentration: 18 ppm/10M | Behavioral: Muscle contraction or spasticity Behavioral: Alteration of classical conditioning | TOXID9 44,303,2005 |
inhalation/Dog | lowest published toxic concentration: 6 ppm/30M | Behavioral: Muscle contraction or spasticity Behavioral: Alteration of classical conditioning | TOXID9 44,303,2005 |
inhalation/Dog | lowest published toxic concentration: 3 ppm/1H | Behavioral: Muscle contraction or spasticity Behavioral: Alteration of classical conditioning | TOXID9 44,303,2005 |
inhalation/Dog | lowest published toxic concentration: 0.75 ppm/4H | Behavioral: Muscle contraction or spasticity Behavioral: Alteration of classical conditioning | TOXID9 44,303,2005 |
inhalation/Dog | lowest published toxic concentration: 0.38 ppm/8H | Behavioral: Muscle contraction or spasticity Behavioral: Alteration of classical conditioning | TOXID9 44,303,2005 |
inhalation/Dog | Lowest published lethal concentration: 65 ppm/10M | TOXID9 44,303,2005 | |
inhalation/Dog | Lowest published lethal concentration: 22 ppm/30M | TOXID9 44,303,2005 | |
inhalation/Dog | Lowest published lethal concentration: 11 ppm/1H | TOXID9 44,303,2005 | |
inhalation/Dog | Lowest published lethal concentration: 2.7 ppm/4H | TOXID9 44,303,2005 | |
inhalation/Dog | Lowest published lethal concentration: 1.4 ppm/8H | TOXID9 44,303,2005 | |
inhalation/guinea pig | lethal concentration (50 percent kill): 100 mg/m3/4H | TOVEFN (6),39,1999 | |
inhalation/hamster | lethal concentration (50 percent kill): 392 ppm/4H | Behavioral: Convulsions or effect on seizure threshold | AMIHAB 12,609,1955 |
inhalation/mouse | lethal concentration (50 percent kill): 172 ppm/4H | Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | AMIHAB 12,609,1955 |
inhalation/rat | lethal concentration (50 percent kill): 252 ppm/4H | Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | AMIHAB 12,609,1955 |
intracerebral/rat | lowest published lethal dose: 27 mg/kg | Behavioral: Convulsions or effect on seizure threshold | BCPCA6 14,1901,1965 |
intraperitoneal/cat | lowest published lethal dose: 30 mg/kg | Behavioral: Somnolence (general depressed activity) Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Cyanosis | EJTXAZ 7,238,1974 |
intraperitoneal/Dog | lethal dose (50 percent kill): 60 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting Lung, Thorax, or Respiration: Other changes | NTIS** AD292-689 |
intraperitoneal/monkey | lethal dose (50 percent kill): 60 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | NTIS** AD292-689 |
intraperitoneal/mouse | lethal dose (50 percent kill): 113 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair | PSEBAA 124,172,1967 |
intraperitoneal/rat | lethal dose (50 percent kill): 102 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TXAPA9 6,371,1964 |
intravenous/Dog | lethal dose (50 percent kill): 60 mg/kg | MEPAAX 24,71,1973 | |
intravenous/mouse | lethal dose (50 percent kill): 250 mg/kg | MEPAAX 24,71,1973 | |
intravenous/rat | lethal dose (50 percent kill): 119 mg/kg | MEPAAX 24,71,1973 | |
oral/mouse | lethal dose (50 percent kill): 155 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | STGNBT -,71,1999 |
oral/rat | lethal dose (50 percent kill): 122 mg/kg | MEPAAX 24,71,1973 | |
oral/rat | lowest published toxic dose: 70 mg/kg | Blood: Changes in leukocyte (WBC) count | TOVEFN -,11,2009 |
oral/rat | lethal dose (50 percent kill): 200 mg/kg | Blood: Changes in leukocyte (WBC) count | TOVEFN -,11,2009 |
oral/rat | lowest published lethal dose: 140 mg/kg | Blood: Changes in leukocyte (WBC) count | TOVEFN -,11,2009 |
skin/Dog | lowest published lethal dose: 301 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TXAPA9 18,649,1971 |
skin/guinea pig | lethal dose (50 percent kill): 1329 mg/kg | Behavioral: Convulsions or effect on seizure threshold | XAWPA2 CWL 2-10,1958 |
skin/rabbit | lethal dose (50 percent kill): 1060 mg/kg | 85INA8 5,210.1(89),1986 | |
skin/rat | lethal dose (50 percent kill): 770 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Convulsions or effect on seizure threshold Blood: Changes in bone marrow not included in above | STGNBT -,71,1999 |
subcutaneous/hamster | lethal dose (50 percent kill): 325 mg/kg | CALEDQ 35,303,1987 | |
unreported route/human | lowest published toxic dose: 10 mg/kg | Behavioral: Headache Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired | STGNBT -,71,1999 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 34 gm/m3/13M/40D | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | EJTXAZ 7,242,1974 |
inhalation/rat | lowest published toxic concentration: 100 mg/m3/4H/30D- intermittent | Blood: Changes in leukocyte (WBC) count | TOVEFN -,11,2009 |
intraperitoneal/rat | lowest published toxic dose: 630 mg/kg/3W- intermittent | Kidney, Ureter, and Bladder: Urine volume increased Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 15,62,1969 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.01 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 4,137,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,1425,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 4,137,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1425,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,1425,1999 |
TOXICOLOGY REVIEW | ATXKA8 28,135,1971 | |
TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
TOXICOLOGY REVIEW | MUREAV 723,108,2011 | |
TOXICOLOGY REVIEW | MUREAV 762,76,2014 | |
TOXICOLOGY REVIEW | MUREAV 783,36,2015 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | MUREAV 823,45,2017 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 ppm (1 mg/m3) (skin) | DTLVS* 3,91,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.01 ppm (0.025 mg/m3), Carcinogen, JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.01 ppm (0.025 mg/m3), Skin, Carcinogen, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.01 ppm (0.025 mg/m3), skin, carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 0.1 ppm (0.25 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.2 mg/m3), C2 Carcinogen, FEB2006 | |
Occupational Exposure Limit-HUNGARY | ceiling concentration 1.2 mg/m3, Carcinogen, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.2 mg/m3), carc, skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.5 ppm (1 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.5 ppm (1 mg/m3);short term exposure limit 1 ppm (2 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.01 ppm (0.025 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.25 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0.01 ppm (0.025 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWEDEN | Group B Carcinogen, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 ppm (1.2 mg/m3), carc 2, skin, sen, JAN2011 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 ppm (1 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.5 ppm (1 mg/m3), Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 ppm (1 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 ppm (1 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 ppm (1 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 ppm (1 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1-DIMETHYLHYDRAZINE-air | Carcinogen ceiling concentration 0.06 ppm/120M | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 84395; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 3; Total Number of Employees Exposed 2917 | |
National Occupational Hazard Survey 1974 | Hazard Code 84395; Number of Industries 2; Total Number of Facilities 14; Number of Occupations 3; Total Number of Employees Exposed 25 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health