Hydantoin, 1,3-dichloro-5,5-dimethyl-

RTECS #

MU0700000

CAS #

118-52-5; 55945-60-3
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

197.03

Molecular Formula

C₅H₆Cl₂N₂O₂

Synonyms

1,3-Dichloro-5,5-dimethyl hydantoin
1,3-Dichloro-5,5-dimethyl hydantoin (ACGIH:OSHA)
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
1,3-Dichloro-5,5-dimethylhydantoin
1,3-Dichloro-5,5'-methylhydantoin
1,3-Dwuchloro-5,5-dwumetylohydantoina (Polish)
2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl- (9CI)
Dactin
Daktin
Dantoin
Dichlorantin
Dwuchlorantyny (Polish)
Halane
Hydan
Hydan (antiseptic)
Hydantoin, dichlorodimethyl-
NCI-C03054
Omchlor

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg/24H	severe	EPASR* 8EHQ-0281-0382
skin /rabbit	100 mg/24H	severe	EPASR* 8EHQ-0281-0382

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
morphological transform	embryo/rat	6300 ng/plate	JJATDK 1,190,1981
sex chromosome loss and nondisjunction	parenteral/Drosophila melanogaster	250 ppm	ENMUDM 7,677,1985

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	Lowest published lethal concentration: 20 gm/m³/1H	Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Changes in structure or function of salivary glands	EPASR* 8EHQ-0281-0382
oral/guinea pig	lethal dose (50 percent kill): 1350 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Lung, Thorax, or Respiration: Dyspnea	GISAAA 47(6),76,1982
oral/rabbit	lethal dose (50 percent kill): 1520 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Lung, Thorax, or Respiration: Dyspnea	GISAAA 47(6),76,1982
oral/rat	lethal dose (50 percent kill): 542 mg/kg		85INA8 5,183,1986
skin/rabbit	lethal dose (50 percent kill): >20 gm/kg		EPASR* 8EHQ-0281-0382
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 500 mg/kg		GWXXBX #2550828
unreported route/rat	lethal dose (50 percent kill): 550 mg/kg		BCTKAG 19,52,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 8784 mg/kg/28D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BCTKAG 19,52,1986
oral/rat	lowest published toxic dose: 634 mg/kg/30D- intermittent	Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 47(6),76,1982

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.2 mg/m³;short term exposure limit 0.4 mg/m³	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.2 mg/m³	DTLVS* 3,78,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.2 mg/m³, short term exposure limit 0.4 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.2 mg/m³;KZW 0.4 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.2 mg/m³, short term exposure limit 0.4 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.2 mg/m³, short term exposure limit 0.6 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.2 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.2 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.2 mg/m³, short term exposure limit 0.4 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 mg/m³;short term exposure limit 0.4 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.2 mg/m³; short term exposure limit 0.4 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.2 mg/m³; short term exposure limit 0.4 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.2 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.2 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.2 mg/m³, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.2 mg/m³;short term exposure limit 0.4 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.2 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.2 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.2 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.2 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10H time-weighted average 0.2 mg/m³;short term exposure limit 0.4 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 24100; Number of Industries 9; Total Number of Facilities 436; Number of Occupations 10; Total Number of Employees Exposed 3502; Total Number of Female Employees Exposed 1780
National Occupational Hazard Survey 1974	Hazard Code 24100; Number of Industries 5; Total Number of Facilities 729; Number of Occupations 6; Total Number of Employees Exposed 2224

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health