Hexane, 1,6-diisocyanato-

RTECS #

MO1740000

CAS #

822-06-0; 66368-96-5
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

168.22

Molecular Formula

C₈H₁₂N₂O₂

Synonyms

1,6-Diisocyanatohexane
1,6-Hexamethylene diisocyanate
1,6-Hexanediol diisocyanate
Desmodur H
Desmodur N
HDI
HDI-IC
Hexamethylendiisokyanat (Czech)
Hexamethylene diisocyanate
Hexamethylene diisocyanate (ACGIH)
Hexamethylene-1,6-diisocyanate
HMDI
Isocyanic acid, diester with 1,6-hexanediol
Isocyanic acid, hexamethylene ester
Metyleno-bis-fenyloizocyjanian (Polish)
Szesciometylenodwuizocyjanian (Polish)
TL 78

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, lung	Inhibitor Concentration (20 percent kill): 1.1 mmol/L	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 30,274,2015
In Vitro/Human, lung fibroblast	Inhibitor Concentration Low: 95 µmol/L/6H	In Vitro Toxicity Studies: Other assays	TIVIEQ 28,209,2014
In Vitro/Human, skin	Inhibitor Concentration (20 percent kill): 40 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1127,2013
inhalation/mouse	lethal concentration (50 percent kill): 30 mg/m³		85GMAT -,74,1982
inhalation/rat	Lowest published lethal concentration: 60 mg/m³/4H	Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GTPZAB 12(10),40,1968
inhalation/rat	lethal concentration (50 percent kill): 124 mg/m³/4H		TOSCF2 58,173,2000
inhalation/rat	lethal concentration (50 percent kill): 462 mg/m³/4H	Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Other proteins	TOSCF2 58,173,2000
inhalation/rat	lowest published toxic concentration: 15.9 mg/m³/6H	Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 58,173,2000
inhalation/rat	lowest published toxic concentration: 54.3 mg/m³/6H	Lung, Thorax, or Respiration: Consolidation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Pleural effusion	TOSCF2 58,173,2000
inhalation/rat	lowest published toxic concentration: 118.1 mg/m³/6H		TOSCF2 58,173,2000
intravenous/mouse	lethal dose (50 percent kill): 5600 µg/kg		CSLNX* NX#07805
oral/mouse	lethal dose (50 percent kill): 350 mg/kg		TAKHAA 39,202,1980
oral/rat	lethal dose (50 percent kill): 710 µL/kg		AIHAAP 30,470,1969
skin/rabbit	lethal dose (50 percent kill): 570 µL/kg		AIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 1 ppm/6H/5D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0571057
inhalation/mouse	lowest published toxic concentration: 300 ppb/6H/5D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0571057
inhalation/mouse	lowest published toxic concentration: 7.5 mg/m³/3D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 261,103,2009
inhalation/rat	lowest published toxic concentration: 0.05 ppm/6H/28D- intermittent	Olfaction: Other olfaction effects	REPTED 14,135,2000
inhalation/rat	lowest published toxic concentration: 0.05 ppm/6H/47D- intermittent	Olfaction: Other olfaction effects	REPTED 14,135,2000
inhalation/rat	lowest published toxic concentration: 0.05 ppm/20D- continuous	Olfaction: Other olfaction effects	TJADAB 162,205,2000
inhalation/rat	lowest published toxic concentration: 50 ppb/6H/30D- intermittent	Olfaction: Other olfaction effects	REPTED 14,135,2000
inhalation/rat	lowest published toxic concentration: 2 ppm/6H/5D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0571057
inhalation/rat	lowest published toxic concentration: 40 ppb/6H/13W- intermittent	Olfaction: Other olfaction effects Eye: Conjunctiva irritation	NTIS** OTS0532755
inhalation/rat	lowest published toxic concentration: 30 ppm/4H/2W- intermittent	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Dyspnea	NTIS** OTS0555659
oral/rat	lowest published toxic dose: 3 gm/kg/2W- intermittent	Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0555659
skin/mouse	lowest published toxic dose: 1 pph/3D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 261,103,2009

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 140-141,213,2003
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.02 mg(NCO)/m³, short term exposure limit 0.07 mg(NCO)/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.005 ppm (0.035 mg/m³);KZW 0.005 ppm (0.035 mg/m³), sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.005 ppm (0.034 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 ppm (0.035 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 0.01 ppm (0.075 mg/m³), VLE 0.02 ppm (0.15 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.005 ppm (0.035 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.035 mg/m³, short term exposure limit 0.035 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.005 ppm (0.03 mg/m³), short term exposure limit 0.01 ppm (0.07 mg/m³), sen, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.005 ppm (0.034 mg/m³), a1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.02 mg(NCO)/m³; short term exposure limit 0.07 mg(NCO)/m³, sen, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,005 ppm (0,034 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.05 mg/m³, short term exposure limit 0.15 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.05 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.002 ppm (0.02 mg/m³), ceiling concentration 0.005 ppm (0.03 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.02 mg(NCO)/m³, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.04 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HDI-air	10H time-weighted average 0.035 mg/m³;ceiling concentration 0.14 mg/m³/10M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M4839; Number of Industries 21; Total Number of Facilities 1895; Number of Occupations 26; Total Number of Employees Exposed 19180; Total Number of Female Employees Exposed 329
National Occupational Hazard Survey 1974	Hazard Code M4839; Number of Industries 9; Total Number of Facilities 238; Number of Occupations 12; Total Number of Employees Exposed 4490

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102543/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NIOSH Analytical Method, 1996: Isocyanates, 5522
On EPA IRIS database
OSHA ANALYTICAL METHOD #42

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health