2-Heptanone

RTECS #

MJ5075000

CAS #

110-43-0
See: NMAM or OSHA Methods

Updated

July 2015

Molecular Weight

114.21

Molecular Formula

C₇H₁₄O

Synonyms

Amyl-methyl-cetone (French)
Ketone, methyl pentyl
Methyl n-amyl ketone
Methyl n-amyl ketone (ACGIH:OSHA)
Methyl pentyl ketone
Methyl-amyl-cetone (French)
n-Amyl methyl ketone

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	14 mg/24H open irritation test	mild	AIHAAP 23,95,1962

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	400 ppm (28D prior to copulation/1-19D pregnant)	Reproductive: Other effects on female	HPV275 -,-,2003

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, skin	Inhibitor Concentration Low: 60 µL/well/10M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1476,2013
inhalation/guinea pig	lowest published toxic concentration: 7000 mg/m³/4H	Lung, Thorax, or Respiration: Cough	VCVGK* -,429,1994
inhalation/guinea pig	lowest published toxic concentration: 9300 mg/m³/4H	Behavioral: General anesthetic	VCVGK* -,429,1994
inhalation/guinea pig	Lowest published lethal concentration: 22400 mg/m³/4H		VCVGK* -,429,1994
inhalation/rat	Lowest published lethal concentration: 4000 ppm/4H		AIHAAP 23,95,1962
inhalation/rat	Lowest published lethal concentration: 4169 ppm/4H	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	HPV048 -,-,2001
intraperitoneal/mouse	lethal dose (50 percent kill): 400 mg/kg		38MKAJ 2C,4757,1982
intraperitoneal/rat	lethal dose (50 percent kill): 800 mg/kg		38MKAJ 2C,4757,1982
oral/mouse	lethal dose (50 percent kill): 730 mg/kg		ENTOX* -,506,2005
oral/rat	lethal dose (50 percent kill): 1600 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	HPV048 -,-,2001
oral/rat	lethal dose (50 percent kill): 1670 mg/kg		UCDS** 8/11/1958
skin/rabbit	lethal dose (50 percent kill): 12600 µL/kg		AIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 400 ppm/34D- intermittent	Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV048 -,-,2001
oral/rat	lowest published toxic dose: 45500 mg/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Changes in bladder weight	FCTXAV 10,625,1972
oral/rat	lowest published toxic dose: 9100 mg/kg/13W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Changes in kidney weight	HPV048 -,-,2001
oral/rat	lowest published toxic dose: 45500 mg/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Changes in kidney weight	HPV048 -,-,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		ENTOX* -,506,2005

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 100 ppm (465 mg/m³)	DTLVS* 3,157,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (233 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (237 mg/m³);KZW 100 ppm (473 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (238 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 100 ppm (475 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (238 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 238 mg/m³ (50 ppm);short term exposure limit 475 mg/m³ (100 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (240 mg/m³), short term exposure limit 75 ppm (360 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 50 ppm (238 mg/m³), VLE 100 ppm (475 mg/m³), Skin, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 238 mg/m³, short term exposure limit 476 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (238 mg/m³), short term exposure limit 100 ppm (475 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 50 ppm (235 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 50 ppm (235 mg/m³);short term exposure limit 100 ppm (465 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 50 ppm (233 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (115 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (233 mg/m³); short term exposure limit 100 ppm (467 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 25 ppm (120 mg/m³);short term exposure limit 50 ppm (250 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 50 ppm (235 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 233 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 50 ppm (237 mg/m³);short term exposure limit 100 ppm (475 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 100 ppm (465 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 100 ppm (465 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 100 ppm (465 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 100 ppm (465 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL AMYL KETONE-air	10H time-weighted average 100 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 36340; Number of Industries 62; Total Number of Facilities 5080; Number of Occupations 47; Total Number of Employees Exposed 78196; Total Number of Female Employees Exposed 17866
National Occupational Hazard Survey 1974	Hazard Code 36340; Number of Industries 10; Total Number of Facilities 489; Number of Occupations 8; Total Number of Employees Exposed 3345

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health