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Heptane

Related Pages
RTECS #
MI7700000
CAS #
142-82-5
See: NMAM or OSHA Methods
Updated
September 2013
Molecular Weight
100.23
Molecular Formula
C7H16
Synonyms
Dipropyl methane
Eptani (Italian)
Gettysolve-C
Heptan (Polish)
Heptane (ACGIH:OSHA)
Heptanen (Dutch)
Heptyl hydride
n-Heptane
n-Heptane (OSHA)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lethal concentration: >17937 ppm/4HNTIS** OTS0556754
inhalation/human lowest published toxic concentration: 1000 ppm/6MBehavioral: Hallucinations, distorted perceptionsBMRII* 2979,-,1929
inhalation/mouse Lowest published lethal concentration: 59 gm/m3/41MBehavioral: Convulsions or effect on seizure thresholdBIZEA2 115,235,1921
inhalation/mouse Lowest published lethal concentration: 75000 mg/m3/2HVCVGH* -,35,1990
inhalation/rat lethal concentration (50 percent kill): >29290 mg/m3HPV250 -,-,2008
inhalation/rat lethal concentration (50 percent kill): 48000 ppm/4HHPV250 -,-,2008
inhalation/rat Lowest published lethal concentration: 65000 mg/m3VCVGH* -,35,1990
inhalation/rat lethal concentration (50 percent kill): 103 gm/m3/4HGTPZAB 32(10),23,1988
intravenous/mouse lethal dose (50 percent kill): 222 mg/kgJPMSAE 67,566,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4000 ppm/6H/28D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Ear: Change in cochlear structure or function

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		PHTOEH 76,41,1995
inhalation/rat lowest published toxic concentration: 420 mg/m3/12H/2W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)		VCVGH* -,35,1990
inhalation/rat lowest published toxic concentration: 2970 ppm/26W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		HPV250 -,-,2008
intraperitoneal/rat lowest published toxic dose: 9625 mg/kg/7D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TOLED5 14,169,1982
intraperitoneal/rat lowest published toxic dose: 8840 mg/kg/45D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		JJATDK 8,81,1988
oral/rat lowest published toxic dose: 60 gm/kg/3W- intermittentLiver: Changes in liver weightNTIS** OTS0571116
oral/rat lowest published toxic dose: 260 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0571116

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 400 ppm;short term exposure limit 500 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,504,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 500 ppm (2000 mg/m3)DTLVS* 3,124,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 400 ppm (1640 mg/m3), short term exposure limit 500 ppm (2050 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (2000 mg/m3);KZW 2000 ppm (8000 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 400 ppm (1664 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 500 ppm (2085 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (820 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 2085 mg/m3 (500 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 300 ppm (1200 mg/m3), short term exposure limit 500 ppm (2100 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 500 ppm (2085 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (2.1 gm/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2000 mg/m3, short term exposure limit 8000 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (820 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (820 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 400 ppm (1600 mg/m3);short term exposure limit 500 ppm (skin), 2004
Occupational Exposure Limit-MEXICOSimple asphyxiant, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 400 ppm (1640 mg/m3); short term exposure limit 500 ppm (2050 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 200 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 400 ppm (1639 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1200 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 200 ppm, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 200 ppm (800 mg/m3);short term exposure limit 300 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 400 ppm (1600 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1200 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 500 ppm (2085 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 500 ppm (2000 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTANE-air10H time-weighted average 85 ppm;ceiling concentration 440 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 36060; Number of Industries 191; Total Number of Facilities 37852; Number of Occupations 134; Total Number of Employees Exposed 449487; Total Number of Female Employees Exposed 44550
National Occupational Hazard Survey 1974Hazard Code 36060; Number of Industries 153; Total Number of Facilities 20154; Number of Occupations 110; Total Number of Employees Exposed 221101

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
On EPA IRIS database
Page last reviewed: November 16, 2018
Content source: National Institute for Occupational Safety and Health