Fibrous glass
RTECS #
LK3651000
CAS #
Updated
December 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms
475' glass fibres
E-glass fibres
Fiberglass
Fibrous glass (OSHA)
Fibrous glass dust (ACGIH)
Glass
Glass fibers
E-glass fibres
Fiberglass
Fibrous glass (OSHA)
Fibrous glass dust (ACGIH)
Glass
Glass fibers
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | lung/human | 5 mg/L/72H | TIVIEQ 29,551,2015 |
| micronucleus test | lung/hamster | 2 µg/cm2 | MUREAV 391,111,1997 |
| other mutation test systems | ovary/hamster | 10 mg/L | MUREAV 116,369,1983 |
| other mutation test systems | fibroblast/human | 10 mg/L | MUREAV 116,369,1983 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| implant/mouse | toxic dose: 1600 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Bladder tumors | BJURAN 36,225,1964 |
| implant/rat | lowest published toxic dose: 200 mg/kg | Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application | JJIND8 67,965,1981 |
| implant/rat | toxic dose: 200 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application | IARCCD 8,289,1973 |
| inhalation/rat | lowest published toxic concentration: 5 mg/m3/7H/90W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTIS** PB83-258111 |
| intraperitoneal/hamster | lowest published toxic dose: 400 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | IAPUDO 30,337,1980 |
| intraperitoneal/rabbit | lowest published toxic dose: 25 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | IAPUDO 30,337,1980 |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | IAPUDO 30,337,1980 |
| intrapleural/rat | toxic dose: 100 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | IAPUDO 30,311,1980 |
| intratracheal/hamster | lowest published toxic dose: 125 mg/kg/5W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | ENVRAL 54,52,1991 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, endothelium | Inhibitor Concentration Low: 0.25 cm2/cm2/7D | In Vitro Toxicity Studies: Other assays | TXCYAC 288,34,2011 |
| In Vitro/Human, lung tumor | Inhibitor Concentration Low: 5 mg/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TIVIEQ 29,551,2015 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 0.25 cm2/cm2/4D | In Vitro Toxicity Studies: Other assays | TXCYAC 288,34,2011 |
| intratracheal/mouse | Lethal dose: >20 mg/kg | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | ARDSBL 141(Suppl),A3-A937,1990 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/hamster | lowest published toxic concentration: 30 mg/m3/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOXID9 36(1 Pt2),7,1997 |
| inhalation/hamster | lowest published toxic concentration: 30 mg/m3/6H/78W- intermittent | Lung, Thorax, or Respiration: Other changes | TOXID9 42,178,1998 |
| inhalation/rat | lowest published toxic concentration: 16 mg/m3/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes | FAATDF 32,31,1996 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 f/cubic centimeter (resp fibers) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 81,-,2002 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 81,-,2002 |
| TOXICOLOGY REVIEW | RTOPDW 60,84,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | NUISANCE PARTICULATES (fibrous or dust) | DTLVS* 3,114,1971 |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3 (dust), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 f/cc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 f/cc, NOV2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 mg/m3, inhal. dust, NOV2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 f/cc, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 1 fcc, 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3 (dust), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 f/cc (respirable fibers), 5 mg/m3 (inspirable dust), JAN2002 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FIBROUS GLASS-air | 10H time-weighted average 3 million fb/m3 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health