Ethylene, tetrachloro-
RTECS #
KX3850000
CAS #
Updated
March 2019
Molecular Weight
165.82
Molecular Formula
C2Cl4
Synonyms
1,1,2,2-Tetrachloroethylene
Ankilostin
Antisol 1
Carbon bichloride
Carbon dichloride
Czterochloroetylen (Polish)
Didakene
Dilatin PT
Dow-per
ENT 1,860
Ethene, tetrachloro-
Ethylene tetrachloride
Ethylenetetrachloride
Fedal-UN
NCI-C04580
PER
Per
Perawin
Perc
Perchloorethyleen, per (Dutch)
Perchlor
Perchloraethylen, per (German)
Perchlorethylene
Perchloroethylene
Perchloroethylene (ACGIH:OSHA)
Perclene
Perclene D
Percloroetilene (Italian)
Percosolve
Perk
PERK
Perklone
Persec
RCRA waste number U210
Tetlen
Tetracap
Tetrachlooretheen (Dutch)
Tetrachloraethen (German)
Tetrachlorethylene
Tetrachloroethene
Tetrachloroethylene
Tetrachloroethylene (DOT:OSHA)
Tetrachloroethylene (IUPAC)
Tetracloroetene (Italian)
Tetraleno
Tetralex
Tetravec
Tetroguer
Tetropil
Ankilostin
Antisol 1
Carbon bichloride
Carbon dichloride
Czterochloroetylen (Polish)
Didakene
Dilatin PT
Dow-per
ENT 1,860
Ethene, tetrachloro-
Ethylene tetrachloride
Ethylenetetrachloride
Fedal-UN
NCI-C04580
PER
Per
Perawin
Perc
Perchloorethyleen, per (Dutch)
Perchlor
Perchloraethylen, per (German)
Perchlorethylene
Perchloroethylene
Perchloroethylene (ACGIH:OSHA)
Perclene
Perclene D
Percloroetilene (Italian)
Percosolve
Perk
PERK
Perklone
Persec
RCRA waste number U210
Tetlen
Tetracap
Tetrachlooretheen (Dutch)
Tetrachloraethen (German)
Tetrachlorethylene
Tetrachloroethene
Tetrachloroethylene
Tetrachloroethylene (DOT:OSHA)
Tetrachloroethylene (IUPAC)
Tetracloroetene (Italian)
Tetraleno
Tetralex
Tetravec
Tetroguer
Tetropil
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 162 mg | mild | EJTXAZ 9,171,1976 |
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,108,1986 |
| skin /rabbit | 810 mg/24H | severe | EJTXAZ 9,171,1976 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,108,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/rat | 500 ppm | NTIS** PB82-185075 |
| Cytogenetic Analysis | other cell types/human | 2 mmol/L/48H | EMMUEG 50,46,2009 |
| DNA Damage | oral/mouse | 1000 mg/kg/24H- intermittent | MUTAEX 25,133,2010 |
| DNA Damage | unreported route/human | 2.4 ppm/1Y | MUREAV 539,9,2003 |
| DNA Damage | intraperitoneal/mouse | 4 mmol/kg | TOLED5 31,31,1986 |
| DNA repair | other cell types/human | 2 mmol/L/48H | EMMUEG 50,46,2009 |
| host-mediated assay | Salmonella typhimurium/mouse | 100 ppm | NTIS** PB82-185075 |
| morphological transform | embryo/rat | 97 µmol/L | ITCSAF 14,290,1978 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µL/plate (+enzymatic activation step) | NIOSH* 5AUG1977 |
| other mutation test systems | oral/mouse | 1 gm/kg | MUREAV 343,157,1995 |
| sex chromosome loss and nondisjunction | lung/hamster | 190 µmol/L | MUREAV 182,135,1987 |
| sperm morphology | inhalation/mouse | 500 ppm | NTIS** PB82-185075 |
| Unscheduled DNA Synthesis | lung/human | 100 mg/L | NTIS** PB82-185075 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 1000 ppm/24H (14D prior to copulation/1-22D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | APTOD9 19,A21,1980 |
| inhalation/rat | 1000 ppm/24H (1-22D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | APTOD9 19,A21,1980 |
| inhalation/rat | 900 ppm/7H (7-13D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TJADAB 19,41A,1979 |
| inhalation/rat | 300 ppm/7H (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TXAPA9 32,84,1975 |
| inhalation/rat | 1000 ppm/6H (multigeneration) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** OTS0557702 |
| inhalation/mouse | 300 ppm/7H (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Homeostasis | TXAPA9 32,84,1975 |
| inhalation/mouse | 500 ppm/7H (5D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTIS** PB82-185075 |
| inhalation/rat | 250 ppm (6-19D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BDERB* 77,405,2006 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 100 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTPTR* NTP-TR-311,1986 |
| inhalation/mouse | toxic concentration: 100 ppm/6H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | TOLED5 31(Suppl),16,1986 |
| inhalation/mouse | lowest published toxic concentration: 6180 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB87-147054/AS |
| inhalation/mouse | lowest published toxic concentration: 2100 mg/m3/6H/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | VCVGH* -,459,1990 |
| inhalation/rat | lowest published toxic concentration: 6180 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTIS** PB87-147054/AS |
| inhalation/rat | lowest published toxic concentration: 5150 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTIS** PB87-147054/AS |
| inhalation/rat | lowest published toxic concentration: 200 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia Reproductive: Tumorigenic effects: Testicular tumors | NTPTR* NTP-TR-311,1986 |
| inhalation/rat | toxic concentration: 200 ppm/6H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Blood: Leukemia | TOLED5 31(Suppl),16,1986 |
| oral/mouse | lowest published toxic dose: 195 gm/kg/50W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-13,1977 |
| oral/mouse | toxic dose: 240 gm/kg/62W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-13,1977 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, skin | Inhibitor Concentration Low: 0.08 mL/well/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,616,2014 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 47 µL/well/45M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,742,2014 |
| In Vitro/iag | Inhibitor Concentration Low: 1.7 mmol/L | In Vitro Toxicity Studies: Other assays | NRTXDN 55,74,2016 |
| In Vitro/Mouse, liver | Inhibitor Concentration (50 percent kill): 0.36 mmol/L/2H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 3,145,1989 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 0.36 mmol/L/2H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 3,145,1989 |
| inhalation/cat | lowest published toxic concentration: 36000 mg/m3/270M | Behavioral: General anesthetic | VCVGH* -,457,1990 |
| inhalation/human | lowest published toxic concentration: 1000 ppm | Behavioral: General anesthetic | VCVGH* -,457,1990 |
| inhalation/human | lowest published toxic concentration: 96 ppm/7H | Peripheral Nerve and Sensation: Local anesthetic Eye: Conjunctiva irritation Behavioral: Hallucinations, distorted perceptions | NTIS** PB257-185 |
| inhalation/human | lowest published toxic concentration: 500 mg/m3/1M | Eye: Conjunctiva irritation | VCVGH* -,457,1990 |
| inhalation/human | lowest published toxic concentration: 650 mg/m3/7H | Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity) Behavioral: Headache | VCVGH* -,457,1990 |
| inhalation/human | lowest published toxic concentration: 1500 mg/m3/20M | Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity) | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 1900 mg/m3/2H | Eye: Conjunctiva irritation Behavioral: Ataxia Gastrointestinal: Nausea or vomiting | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 2700 mg/m3/3H | Behavioral: Somnolence (general depressed activity) Liver: Other changes | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 3500 mg/m3/10M | Lung, Thorax, or Respiration: Cough | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 6400 mg/m3 | Eye: Conjunctiva irritation Gastrointestinal: Changes in structure or function of salivary glands | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 13500 mg/m3/5M | Gastrointestinal: Changes in structure or function of salivary glands | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 200 ppm | Eye: Conjunctiva irritation | VCVGH* -,458,1990 |
| inhalation/human | lowest published toxic concentration: 6000 ppm/1M | Behavioral: Coma Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Hepatitis (hepatocellular necrosis), diffuse | VCVGH* -,458,1990 |
| inhalation/man | lowest published toxic concentration: 600 ppm/10M | Eye: Conjunctiva irritation Behavioral: General anesthetic | AMIHBC 5,566,1952 |
| inhalation/mouse | lethal concentration (50 percent kill): 5200 ppm/4H | APTOA6 9,303,1953 | |
| inhalation/mouse | lowest published toxic concentration: 20000 mg/m3/2H | Behavioral: General anesthetic | VCVGH* -,456,1990 |
| inhalation/mouse | Lowest published lethal concentration: 40000 mg/m3/2H | VCVGH* -,456,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 35000 mg/m3/4H | VCVGH* -,456,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 20200 mg/m3/6H | VCVGH* -,456,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 2978 ppm/6H | ENTOX* -,150,2005 | |
| inhalation/mouse | lowest published toxic concentration: 1340 mg/m3/4H | Liver: Fatty liver degeneration | VCVGH* -,457,1990 |
| inhalation/mouse | lowest published toxic concentration: 3390 mg/m3/4H | Liver: Other changes | VCVGH* -,457,1990 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/35M | Behavioral: Alteration of operant conditioning | NETEEC 30,167,2008 |
| inhalation/rat | lowest published toxic concentration: 1500 ppm/12M | Behavioral: Alteration of operant conditioning | NETEEC 30,167,2008 |
| inhalation/rat | lowest published toxic concentration: 500 ppm/60M | Behavioral: Alteration of operant conditioning | NETEEC 30,167,2008 |
| inhalation/rat | Lowest published lethal concentration: 40800 mg/m3/1M | Behavioral: General anesthetic | VCVGH* -,456,1990 |
| inhalation/rat | Lowest published lethal concentration: 40800 mg/m3/5H | VCVGH* -,456,1990 | |
| inhalation/rat | lethal concentration (50 percent kill): 4100 ppm/6H | ENTOX* -,150,2005 | |
| inhalation/rat | lethal concentration (50 percent kill): 34200 mg/m3/8H | AIHAAP 20,364,1959 | |
| intraperitoneal/Dog | lethal dose (50 percent kill): 2100 mg/kg | Liver: Liver function tests impaired | TXAPA9 10,119,1967 |
| intraperitoneal/mouse | Lethal dose: >500 mg/kg | CBCCT* 4,378,1952 | |
| intraperitoneal/mouse | lowest published toxic dose: 1000 mg/kg | Behavioral: Change in psychophysiological tests | TXAPA9 279,103,2014 |
| intraperitoneal/rat | lethal dose (50 percent kill): 4678 mg/kg | ENVRAL 40,411,1986 | |
| intratracheal/rat | lowest published lethal dose: 450 mg/kg | NTIS** OTS0520615 | |
| intravenous/Dog | lowest published lethal dose: 85 mg/kg | QJPPAL 7,205,1934 | |
| oral/cat | lowest published lethal dose: 4 gm/kg | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) | AJHYA2 9,430,1929 |
| oral/child | lowest published toxic dose: 545 mg/kg | Behavioral: Coma | JTCTDW 23,103,1985 |
| oral/Dog | lowest published lethal dose: 4 gm/kg | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) | AJHYA2 9,430,1929 |
| oral/Dog | lowest published toxic dose: 306 mg/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration | VCVGH* -,457,1990 |
| oral/mouse | lowest published toxic dose: 150 mg/kg | Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TXCYAC 232,1,2007 |
| oral/mouse | lowest published toxic dose: 500 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | TXCYAC 232,1,2007 |
| oral/mouse | lethal dose (50 percent kill): 8100 mg/kg | Behavioral: General anesthetic | NTIS** PB257-185 |
| oral/mouse | lethal dose (50 percent kill): 6400 mg/kg | VCVGH* -,457,1990 | |
| oral/rabbit | lowest published lethal dose: 5 gm/kg | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) | AJHYA2 9,430,1929 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Anticonvulsant | TXCYAC 170,201,2002 |
| oral/rat | lethal dose (50 percent kill): 2629 mg/kg | AIHAAP 20,364,1959 | |
| skin/rabbit | Lethal dose: >3228 mg/kg | NTIS** AD-A180-198 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 65 gm/kg | Behavioral: Sleep Behavioral: Ataxia | JPETAB 123,224,1958 |
| subcutaneous/rabbit | lowest published lethal dose: 2200 mg/kg | QJPPAL 7,205,1934 | |
| unreported route/human | lowest published lethal dose: 0.7 mL/kg | VCVGH* -,457,1990 | |
| unreported route/rat | lethal dose (50 percent kill): 4000 mg/kg | VCVGH* -,457,1990 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/gerbil | lowest published toxic concentration: 120 ppm/24H/1Y- continuous | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 22,343,1984 |
| inhalation/guinea pig | lowest published toxic concentration: 680 mg/m3/200D- continuous | Liver: Changes in liver weight | VCVGH* -,460,1990 |
| inhalation/guinea pig | lowest published toxic concentration: 200 ppm/7H/32W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHBC 5,566,1952 |
| inhalation/mouse | lowest published toxic concentration: 100 ppm/104W- intermittent | Liver: Tumors | TXCYAC 260,77,2009 |
| inhalation/mouse | lowest published toxic concentration: 200 ppm/4H/8W- intermittent | Liver: Fatty liver degeneration | APTOA6 22,379,1965 |
| inhalation/mouse | lowest published toxic concentration: 1750 ppm/6H/14D- intermittent | Liver: Fatty liver degeneration | NTPTR* NTP-TR-311,1986 |
| inhalation/mouse | lowest published toxic concentration: 1600 ppm/6H/13W- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-311,1986 |
| inhalation/rabbit | lowest published toxic concentration: 2500 ppm/7H/39D- intermittent | Behavioral: Somnolence (general depressed activity) | AMIHBC 5,566,1952 |
| inhalation/rat | lowest published toxic concentration: 1750 ppm/6H/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-311,1986 |
| inhalation/rat | lowest published toxic concentration: 19300 mg/m3/24H/94D- continuous | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 42(8),50,1977 |
| inhalation/rat | lowest published toxic concentration: 200 ppm/4W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOLED5 54,207,1990 |
| inhalation/rat | lowest published toxic concentration: 7000 ppm/8H/50D- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney Blood: Changes in spleen | JIHTAB 19,323,1937 |
| inhalation/rat | lowest published toxic concentration: 1500 mg/m3/8H/28W- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | VCVGH* -,459,1990 |
| inhalation/rat | lowest published toxic concentration: 10900 mg/m3/2W- continuous | Gastrointestinal: Changes in structure or function of salivary glands Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia | VCVGH* -,459,1990 |
| inhalation/rat | lowest published toxic concentration: 1700 ppm/10D- intermittent | Reproductive: Effects on fertility: Other measures of fertility | REPTED 17,273,2003 |
| inhalation/rat | lowest published toxic concentration: 600 ppm/3D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 77,405,2006 |
| inhalation/rat | lowest published toxic concentration: 500 ppm/12D- intermittent | Behavioral: Tolerance | NETEEC 30,167,2008 |
| inhalation/rat | lowest published toxic concentration: 320 ppm/30D- intermittent | Brain and Coverings: Other degenerative changes Brain and Coverings: Changes in brain weight Biochemical: Metabolism (intermediary): Lipids including transport | SWEHDO 14,91,1988 |
| intramuscular/gerbil | lowest published toxic dose: 320 ppm/90D- continuous | Brain and Coverings: Other degenerative changes Brain and Coverings: Changes in brain weight Biochemical: Metabolism (intermediary): Lipids including transport | ARTODN 60,397,1987 |
| intramuscular/gerbil | lowest published toxic dose: 120 ppm/1Y- continuous | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 22,343,1984 |
| intramuscular/rat | lowest published toxic dose: 320 ppm/90D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 52,279,1990 |
| intramuscular/rat | lowest published toxic dose: 320 ppm/30D- continuous | Brain and Coverings: Changes in brain weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Lipids including transport | SWEHDO 14,91,1988 |
| intraperitoneal/rat | lowest published toxic dose: 49750 µg/kg/3D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver: Other changes | TIHEEC 8,191,1992 |
| oral/mouse | lowest published toxic dose: 23215 mg/kg/8W- intermittent | Immunological Including Allergic: Autoimmune (multiple organ involvement) | TOXID9 54,74,2000 |
| oral/mouse | lowest published toxic dose: 30000 mg/kg/30D- intermittent | Behavioral: Tremor Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXCYAC 232,1,2007 |
| oral/mouse | lowest published toxic dose: 7000 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXCYAC 232,1,2007 |
| oral/mouse | lowest published toxic dose: 1050 mg/kg/7D- intermittent | Liver: Other changes | TXCYAC 232,1,2007 |
| oral/mouse | lowest published toxic dose: 3500 mg/kg/7D- intermittent | Kidney, Ureter, and Bladder: Other changes | TXCYAC 232,1,2007 |
| oral/rat | lowest published toxic dose: 7000 mg/kg/7D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | CALEDQ 106,235,1996 |
| oral/rat | lowest published toxic dose: 12.6 gm/kg/2W- continuous | Reproductive: Effects on fertility: Other measures of fertility | REPTED 17,273,2003 |
| oral/rat | lowest published toxic dose: 200 mg/kg/40D- intermittent | Behavioral: Anticonvulsant Behavioral: Analgesia | TXCYAC 170,201,2002 |
| oral/rat | lowest published toxic dose: 2000 mg/kg/40D- intermittent | Behavioral: Anticonvulsant Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 170,201,2002 |
| oral/rat | lowest published toxic dose: 14 gm/kg/4W- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition | ENVRAL 59,427,1992 |
| oral/rat | lowest published toxic dose: 36 gm/kg/90D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FAATDF 7,119,1986 |
| oral/rat | lowest published toxic dose: 3 gm/kg/6W- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Lipids including transport | TXAPA9 78,105,1985 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 25 ppm;short term exposure limit 100 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMSUDL 7,355,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 63,159,1995 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 63,159,1995 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 106,329,2014 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMSUDL 7,355,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 106,329,2014 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMSUDL 7,355,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 106,329,2014 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 63,159,1995 |
| TOXICOLOGY REVIEW | CMSHAF 6,517,1977 | |
| TOXICOLOGY REVIEW | AJMEAZ 38,409,1965 | |
| TOXICOLOGY REVIEW | TOLED5 127,111,2002 | |
| TOXICOLOGY REVIEW | TOLED5 134,17,2002 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
| TOXICOLOGY REVIEW | CRTXB2 33,137,2003 | |
| TOXICOLOGY REVIEW | TXCYAC 196,1,2004 | |
| TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
| TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
| TOXICOLOGY REVIEW | MUREAV 627,59,2007 | |
| TOXICOLOGY REVIEW | ENTOX* -,150,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
| TOXICOLOGY REVIEW | MUREAV 682,94,2009 | |
| TOXICOLOGY REVIEW | NEUCL* 23,485,2005 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,689,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,711,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,727,1995 | |
| TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
| TOXICOLOGY REVIEW | NRTXDN 31,603,2010 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | TXAPA9 255,113,2011 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | TXAPA9 266,345,2013 | |
| TOXICOLOGY REVIEW | MUREAV 770,170,2016 | |
| TOXICOLOGY REVIEW | MUREAV 770,183,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 59,364,2011 | |
| TOXICOLOGY REVIEW | MUTAEX 33,179,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,269,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (670 mg/m3) | DTLVS* 3,201,1971 |
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 ppm (35 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 50 ppm (340 mg/m3), short term exposure limit 150 ppm (1020 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 50 ppm (345 mg/m3);KZW 200 ppm (1380 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 25 ppm (172 mg/m3), short term exposure limit 100 ppm(695 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (70 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 50 ppm (335 mg/m3), C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 50 mg/m3, short term exposure limit 50 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (70 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | skin, 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 50 ppm (335 mg/m3), short term exposure limit 200 ppm (1340 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (670 mg/m3);short term exposure limit 200 ppm (1340 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 50 ppm (335 mg/m3), short term exposure limit 150 ppm (1005 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 20 ppm (130 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 25 ppm (170 mg/m3); short term exposure limit 100 ppm (678 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 60 mg/m3, MAC(short term exposure limit) 480 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (70 mg/m3);short term exposure limit 25 ppm (170 mg/m3), Carcinogen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 50 ppm (345 mg/m3), KZG-week 100 ppm (690 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 100 ppm, short term exposure limit 200 ppm, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 240 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (670 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 50 ppm (345 mg/m3);short term exposure limit 100 ppm (689 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (670 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (670 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm;ceiling concentration 200;Pk 300/5M/3H | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (670 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRACHLOROETHYLENE-air | Carcinogen lowest feasible conc. | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 54790; Number of Industries 268; Total Number of Facilities 49025; Number of Occupations 151; Total Number of Employees Exposed 688110; Total Number of Female Employees Exposed 177342 | |
| National Occupational Hazard Survey 1974 | Hazard Code 54790; Number of Industries 288; Total Number of Facilities 52013; Number of Occupations 155; Total Number of Employees Exposed 549154 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101181/AS) | |
| EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE | |
| EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat | |
| EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo | |
| EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis | |
| EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA Section 8(e) Risk Notification, 8EHQ-0294-8618;8EHQ-0393-8762 | |
| EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8618;8EHQ-0393-8618 | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat | NCITR* NCI-TR-13,1977 |
| NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat | |
| NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003 | |
| NIOSH Analytical Method, 1996: Volatile organic compound, 2549 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 20, 1978 | |
| NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen | |
| NTP Carcinogenesis Studies (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-311,1986 | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #1001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health