Ethylene, bromo-
RTECS #
KU8400000
CAS #
Updated
March 2019
Molecular Weight
106.96
Molecular Formula
C2H3Br
Synonyms
Bromoethene
Bromoethene (9CI)
Bromoethylene
Bromure de vinyle (French)
Ethene, bromo-
NCI-C50373
Vinile (bromuro di) (Italian)
Vinyl bromide
Vinyl bromide (ACGIH)
Vinylbromid (German)
Vinyle (bromure de) (French)
Bromoethene (9CI)
Bromoethylene
Bromure de vinyle (French)
Ethene, bromo-
NCI-C50373
Vinile (bromuro di) (Italian)
Vinyl bromide
Vinyl bromide (ACGIH)
Vinylbromid (German)
Vinyle (bromure de) (French)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | oral/mouse | 2 gm/kg | MUREAV 419,13,1998 |
| morphological transform | inhalation/rat | 2000 ppm/14W- intermittent | ARTODN 47,71,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 2 pph/16H (+/-enzymatic activation step) | ARTODN 41,249,1979 |
| sex chromosome loss and nondisjunction | inhalation/Drosophila melanogaster | 14500 ppm | CRNGDP 17,1083,1996 |
| specific locus test | inhalation/Drosophila melanogaster | 54000 ppm | CRNGDP 17,1083,1996 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 10 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Vascular: Tumors | TXAPA9 64,367,1982 |
| inhalation/rat | toxic concentration: 10 ppm | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Blood: Lymphoma including Hodgkin's disease | CHWKA9 123(24),25,1978 |
| inhalation/rat | toxic concentration: 52 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Vascular: Tumors | TXAPA9 64,367,1982 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lowest published lethal concentration: 50000 ppm/7H | 85INA8 6,1690,1991 | |
| inhalation/rat | lowest published toxic concentration: 109000 mg/m3/7H | Behavioral: General anesthetic | VCVGH* -,599,1990 |
| inhalation/rat | Lowest published lethal concentration: 219000 mg/m3/7H | VCVGH* -,599,1990 | |
| oral/rat | lethal dose (50 percent kill): 500 mg/kg | DOWCC* -,12,1966 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 10000 ppm/7H/4W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AIHAAP 31,1,1970 |
| inhalation/rat | lowest published toxic concentration: 250 ppm/6H/26W- intermittent | Cardiac: Changes in heart weight Liver: Changes in liver weight | AIHAAP 31,1,1970 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Suspected human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 39,133,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,923,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 97,454,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 39,133,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,923,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review: Group 2A | IMEMDT 97,454,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 97,454,2008 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 71,923,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 97,454,2008 |
| TOXICOLOGY REVIEW | VHTODE 22,31,1980 | |
| TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,435,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | MUTAEX 33,179,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 250 ppm (1100 mg/m3) | DTLWS* 3,31,1972 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (22 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (22 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (20 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (4.4 mg/m3), NOV2011 | |
| Occupational Exposure Limit-HUNGARY | ceiling concentration 22 mg/m3, Carcinogen, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (20 mg/m3), carc, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2A carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (22 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (4 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 ppm (2.2 mg/m3), JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (22 mg/m3), carc 2, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.012 mg/m3, 2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL BROMIDE-air | Carcinogen lowest feasible concentration | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 84575; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1822; Total Number of Female Employees Exposed 272 | |
| National Occupational Hazard Survey 1974 | Hazard Code 84575; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Vinyl bromide, 1009 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 28, 1978 | |
| NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #08 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health