Ethylamine, 2,2'-oxybis(N,N-dimethyl-
RTECS #
KR9460000
CAS #
Updated
September 2013
Molecular Weight
160.30
Molecular Formula
C8H20N2O
Synonyms
2,2'-Oxybis(N,N-dimethylethylamine)
A 99 (Amine)
Bis(2-dimethylaminoethyl)ether
Dabco BL 11
Dabco BL 19
Dabco BL 19I
Kalpur PC
Niax A 1
Niax A 99
Texacat ZF 20
Toyocat ET
Toyocat ETS
A 99 (Amine)
Bis(2-dimethylaminoethyl)ether
Dabco BL 11
Dabco BL 19
Dabco BL 19I
Kalpur PC
Niax A 1
Niax A 99
Texacat ZF 20
Toyocat ET
Toyocat ETS
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 1 mg | severe | UCDS** 12/27/1971 |
| eye /rabbit | 250 µg/24H | severe | 85JCAE -,721,1986 |
| skin /rabbit | 10% | JAPTO* 25,260,2005 | |
| skin /rabbit | 5 mg/24H | severe | 85JCAE -,721,1986 |
| skin /rabbit | 500 mg open irritation test | severe | UCDS** 12/27/1971 |
| skin /rabbit | 100 mg/24H | severe | JTOTDO 5,3,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sister chromatid exchange | ovary/hamster | 0.005 pph (-enzymatic activation step) | JAPTO* 25,260,2005 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/rabbit | 650 mg/kg (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | JTOTDO 5,263,1986 |
| skin/rabbit | 700 µg/kg (6-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JAPTO* 25,260,2005 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 117 ppm/6H | Eye: Corneal damage Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes | NTIS** OTS0536387 |
| inhalation/rat | lethal concentration (50 percent kill): 166 ppm/6H | Behavioral: Somnolence (general depressed activity) | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 68 ppm/6H | Eye: Conjunctiva irritation | JAPTO* 25,260,2005 |
| inhalation/rat | Lowest published lethal concentration: 149 ppm/6H | Olfaction: Other olfaction effects Eye: Corneal damage Lung, Thorax, or Respiration: Respiratory depression | JAPTO* 25,260,2005 |
| inhalation/rat | Lowest published lethal concentration: 149 ppm/6H | Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 171 mg/kg | JAPTO* 25,260,2005 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 128 mg/kg | Behavioral: Sleep | JAPTO* 25,260,2005 |
| intravenous/rabbit | lethal dose (50 percent kill): 183 mg/kg | JAPTO* 25,260,2005 | |
| intravenous/rat | lethal dose (50 percent kill): 286 mg/kg | JAPTO* 25,260,2005 | |
| ocular/rabbit | lowest published toxic concentration: 10 pph | Eye: Corneal damage | JAPTO* 25,260,2005 |
| ocular/rabbit | lowest published toxic concentration: 1 pph | Eye: Other eye effects | JAPTO* 25,260,2005 |
| ocular/rabbit | lowest published toxic concentration: 4.6 ppm/2H | Eye: Conjunctiva irritation Eye: Corneal damage | JAPTO* 25,260,2005 |
| oral/rat | lethal dose (50 percent kill): 571 mg/kg | NTIS** OTS0545161 | |
| oral/rat | lethal dose (50 percent kill): 1045 mg/kg | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes | JAPTO* 25,260,2005 |
| oral/rat | lethal dose (50 percent kill): 1045 mg/kg | Gastrointestinal: Other changes Liver: Other changes Blood: Hemorrhage | JAPTO* 25,260,2005 |
| oral/rat | lethal dose (50 percent kill): 1045 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| skin/rabbit | lethal dose (50 percent kill): 348 mg/kg/4H | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands | JAPTO* 25,260,2005 |
| skin/rabbit | lethal dose (50 percent kill): 314 mg/kg/24H | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands | JAPTO* 25,260,2005 |
| skin/rabbit | lethal dose (50 percent kill): 280 µL/kg | AIHAAP 30,470,1969 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 20 ppm/6H/9D- intermittent | Olfaction: Other olfaction effects Eye: Ptosis Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536526 |
| inhalation/rat | lowest published toxic concentration: 47 ppm/5D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 90 ppm/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 22 ppm/11D- intermittent | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Endocrine: Hyperglycemia | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 22 ppm/11D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 22 ppm/11D- intermittent | Nutritional and Gross Metabolic: Dehydration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 47 ppm/11D- intermittent | Cardiac: Changes in coronary arteries Lung, Thorax, or Respiration: Other changes Liver: Other changes | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 47 ppm/11D- intermittent | Blood: Changes in spleen | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 5.8 ppm/14W- intermittent | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| inhalation/rat | lowest published toxic concentration: 1.25 ppm/13W- intermittent | Eye: Corneal damage | JAPTO* 25,260,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 0.14 mg/kg/14D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| intraperitoneal/rat | lowest published toxic dose: 0.14 mg/kg/14D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| oral/rat | lowest published toxic dose: 1540 mg/kg/7D- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0536157 |
| skin/rabbit | lowest published toxic dose: 292 mg/kg/11D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTOTDO 5,3,1986 |
| skin/rabbit | lowest published toxic dose: 391 mg/kg/13W- intermittent | Skin: After systemic exposure: Dermatitis, other | JTOTDO 5,3,1986 |
| skin/rabbit | lowest published toxic dose: 0.225 mg/kg/11D- intermittent | Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.225 mg/kg/11D- intermittent | Skin: After topical application: Primary irritation Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in kidney weight | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.45 mg/kg/11D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.45 mg/kg/11D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in kidney weight | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.26 mg/kg/13W- intermittent | Skin: After topical application: Primary irritation | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.7 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 25,260,2005 |
| skin/rabbit | lowest published toxic dose: 0.35 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Skin: After topical application: Primary irritation | JAPTO* 25,260,2005 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin) | DTLVS* TLV/BEI,2013 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-air | minimize exposure | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code T0015; Number of Industries 2; Total Number of Facilities 60; Number of Occupations 5; Total Number of Employees Exposed 1529; Total Number of Female Employees Exposed 165 | |
| National Occupational Hazard Survey 1974 | Hazard Code T0015; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 2; Total Number of Employees Exposed 40 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health