Ether, 2,2,2-trifluoroethyl vinyl

RTECS #

KO4250000

CAS #

406-90-6
See: NMAM or OSHA Methods

Updated

April 2012

Molecular Weight

126.09

Molecular Formula

C₄H₅F₃O

Synonyms

2,2,2-Trifluoroethyl vinyl ether
Ethene, (2,2,2-trifluoroethoxy)-
Floroxene
Fluooxene
Fluoromar
Fluoroxene
Fluorxene
Fluroxene

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	5 pph (-enzymatic activation step)	MUREAV 58,183,1978
mutation in microorganisms	/Escherichia coli	5 pph (+enzymatic activation step)	MUREAV 58,183,1978
sex chromosome loss and nondisjunction	inhalation/Drosophila melanogaster	2 pph/1H	ANESAV 62,305,1985
sister chromatid exchange	ovary/hamster	24700 ppm	ANESAV 50,426,1979

Route/Organism	Dose	Effect	Reference
inhalation/monkey	8 pph/20M (22W pregnant)	Reproductive: Other effects to embryo or fetus	AANEAB 20,183,1976

Route/Organism	Dose	Effect	Reference
inhalation/man	lowest published toxic concentration: 2 pph/90M	Liver: Jaundice, other or unclassified Liver: Liver function tests impaired	ANESAV 37,462,1972
inhalation/mouse	Lowest published lethal concentration: 4 pph/1H		BJANAD 48,399,1976
intraperitoneal/rat	lethal dose (50 percent kill): 5600 mg/kg		TXAPA9 71,84,1983

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal No Adequate Data	IMSUDL 7,93,1987
TOXICOLOGY REVIEW		DIMON* 39,678,1993
TOXICOLOGY REVIEW		NBREV* 5,1,1981

Organization	Standard	Reference
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (10 mg/m³);KZW 4 ppm (20 mg/m³), 2007
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (10 mg/m³), MAY2011
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (10 mg/m³), NOV2011

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUROXENE-air	ceiling concentration 2 ppm/60M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M5153; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 5
National Occupational Hazard Survey 1974	Hazard Code M5153; Number of Industries 1; Total Number of Facilities 112; Number of Occupations 3; Total Number of Employees Exposed 448

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY

Page last reviewed: November 16, 2018