Ether, chloromethyl methyl

RTECS #

KN6650000

CAS #

107-30-2
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

80.52

Molecular Formula

C₂H₅ClO

Synonyms

Chlordimethylether (Czech)
Chloromethyl methyl ether
Chloromethyl methyl ether (ACGIH:OSHA)
Chloromethyl methyl ether, technical grade
CMME
Dimethylchloroether
Ether methylique monochlore (French)
Ether, dimethyl chloro
Methoxychloromethane
Methylchloromethyl ether
Monochlorodimethyl ether
RCRA waste number U046

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA inhibition	lymphocyte/human	5 mL/L	CALEDQ 13,213,1981
morphological transform	embryo/hamster	10 mg/L	AETODY 1,241,1980

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/hamster	lowest published toxic concentration: 1 ppm/6H/90D	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	AEHLAU 30,70,1975
inhalation/hamster	lowest published toxic concentration: 1 ppm/852D- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma Tumorigenic: Increased incidence of tumors in susceptible strains	HPV174 -,-,2003
inhalation/mouse	lowest published toxic concentration: 2 ppm/21W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV174 -,-,2003
inhalation/mouse	lowest published toxic concentration: 2 ppm/82D- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	AEHLAU 22,663,1971
inhalation/rat	lowest published toxic concentration: 1 ppm/6H/72W	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Endocrine: Tumors	AEHLAU 30,70,1975
inhalation/rat	lowest published toxic concentration: 1 ppm/852D- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma Tumorigenic: Increased incidence of tumors in susceptible strains	HPV174 -,-,2003
subcutaneous/mouse	lowest published toxic dose: 5 ml/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV174 -,-,2003
subcutaneous/mouse	lowest published toxic dose: 312 mg/kg/26W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application	JNCIAM 46,143,1971
subcutaneous/mouse	toxic dose: 852 mg/kg/71W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application	JNCIAM 48,1431,1972
subcutaneous/mouse	toxic dose: 125 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	TXAPA9 15,92,1969

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/hamster	lethal concentration (50 percent kill): 65 ppm/7H	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage	AEHLAU 30,61,1975
inhalation/hamster	lethal concentration (50 percent kill): 212.5 mg/m³/7H	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes	VCVGK* -,278,1994
inhalation/mouse	Lowest published lethal concentration: 330 mg/m³/2H		VCVGK* -,278,1994
inhalation/mouse	lethal concentration (50 percent kill): 1030 mg/m³/2H		85GMAT -,89,1982
inhalation/rabbit	lowest published toxic concentration: 9 mg/m³	Lung, Thorax, or Respiration: Cough	VCVGK* -,278,1994
inhalation/rabbit	lowest published toxic concentration: 27 mg/m³	Behavioral: Alteration of classical conditioning	VCVGK* -,278,1994
inhalation/rat	lethal concentration (50 percent kill): 55 ppm/7H	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage	AEHLAU 30,61,1975
inhalation/rat	lethal concentration (50 percent kill): 179.8 mg/m³/7H	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes	VCVGK* -,278,1994
inhalation/rat	lethal concentration (50 percent kill): 55 ppm/7H	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Changes in lung weight	HPV174 -,-,2003
oral/rat	lowest published lethal dose: 1000 mg/kg		HPV174 -,-,2003
oral/rat	lethal dose (50 percent kill): 223 mg/kg		HPV174 -,-,2003

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 6 mg/m³/130D- intermittent	Lung, Thorax, or Respiration: Tumors	VCVGK* -,278,1994
inhalation/rabbit	lowest published toxic concentration: 3 mg/m³/5H/90D- intermittent	Lung, Thorax, or Respiration: Other changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,278,1994
inhalation/rat	lowest published toxic concentration: 32.7 mg/m³/30D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,278,1994
inhalation/rat	lowest published toxic concentration: 3.27 mg/m³/130W- continuous	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Skin and Appendages: Tumors	VCVGK* -,278,1994
inhalation/rat	lowest published toxic concentration: 10 ppm/3D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV174 -,-,2003

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Control as low as possible	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Suspected human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 100F,306,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 100F,306,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMSUDL 7,131,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 100F,306,2012
TOXICOLOGY REVIEW		EESADV 1,289,1977
TOXICOLOGY REVIEW		MUREAV 566,21,2004
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 733,39,2012
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Carcinogen, JUL2008
Occupational Exposure Limit-JAPAN	2A carc, MAY2012
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.5 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	Group A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	see Code of Federal Regulations (CFR) 29,1926.1108	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agent		CFRGBR 29,1910.1006,1987

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROMETHYL METHYL ETHER-air	Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1006	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #10

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health