Ether, bis(2,3-epoxypropyl)

RTECS #

KN2350000

CAS #

2238-07-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

130.16

Molecular Formula

C₆H₁₀O₃

Synonyms

DGE (OSHA)
Di(2,3-epoxy)propyl ether
Diglycidyl ether
Diglycidyl ether (ACGIH:OSHA)
Ether, diglycidyl

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	113 mg	severe	AMIHAB 14,250,1956
eye /rabbit	750 µg/24H	severe	85JCAE -,773,1986
skin /rabbit	563 mg/3D	severe	AMIHAB 14,250,1956
skin /rabbit	20 mg/24H	moderate	85JCAE -,773,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (+/-enzymatic activation step)	MUREAV 66,367,1979

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
unreported route/mouse	lowest published toxic dose: 1300 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	RARSAM 3,193,1963

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 30 ppm/4H	Lung, Thorax, or Respiration: Other changes	AMIHAB 14,250,1956
inhalation/rat	lethal concentration (50 percent kill): 200 ppm/4H		85JCAE -,773,1986
intravenous/mouse	lethal dose (50 percent kill): 100 mg/kg		CSLNX* NX#00108
intravenous/rabbit	lowest published lethal dose: 200 mg/kg	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Hepatitis (hepatocellular necrosis), diffuse	AEHLAU 2,31,1961
oral/mouse	lethal dose (50 percent kill): 170 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	AMIHAB 14,250,1956
oral/rat	lethal dose (50 percent kill): 450 mg/kg	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	AMIHAB 14,250,1956
skin/rabbit	lowest published lethal dose: 1500 mg/kg	Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Skin: After systemic exposure: Dermatitis, irritative	AMIHAB 14,250,1956
skin/rat	lethal dose (50 percent kill): 1 gm/kg		85JCAE -,773,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 2 ppm/4H/29D- intermittent	Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight Blood: Changes in leukocyte (WBC) count	AEHLAU 2,31,1961
skin/rat	lowest published toxic dose: 2500 mg/kg/4W- intermittent	Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AEHLAU 2,31,1961

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.01 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	air-ceiling concentration 0.5 ppm (2.8 mg/m³)	DTLVS* 3,86,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.53 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.6 mg/m³);KZW 0.2 ppm (1.2 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.54 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.53 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.2 ppm (1.1 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 ppm (0.5 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.53 mg/m³), short term exposure limit 0.2 ppm (1.1 mg/m³), sen, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.5 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 ppm (0.5 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.53 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,1 ppm (0,53 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	ceiling concentration 0.2 ppm (1.1 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (0.5 mg/m³), carc 3, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.5 ppm (2.8 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.5 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 ppm (2.8 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.5 ppm (2.8 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 0.5 ppm (2.8 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 0.5 ppm (2.8 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 0.5 ppm (2.8 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 0.5 ppm (2.8 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIGLYCIDYL ETHER-air	10H Carcinogen time-weighted average 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 12846; Number of Industries 1; Total Number of Facilities 29; Number of Occupations 1; Total Number of Employees Exposed 86

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health