Ethanol, 2,2'-iminodi-
RTECS #
KL2975000
CAS #
Updated
March 2019
Molecular Weight
105.16
Molecular Formula
C4H11NO2
Synonyms
2-(2-Hydroxyethylamino)ethanol
2,2'-Dihydroxydiethylamine
2,2'-Iminobisethanol
2,2'-Iminodiethanol
Bis(2-hydroxyethyl)amine
DEA
Di(2-hydroxyethyl)amine
Diaethanolamin (German)
Diethanolamin (Czech)
Diethanolamine
Diethanolamine (ACGIH)
Diethylamine, 2,2'-dihydroxy-
Diethylolamine
Diolamine
NCI-C55174
2,2'-Dihydroxydiethylamine
2,2'-Iminobisethanol
2,2'-Iminodiethanol
Bis(2-hydroxyethyl)amine
DEA
Di(2-hydroxyethyl)amine
Diaethanolamin (German)
Diethanolamin (Czech)
Diethanolamine
Diethanolamine (ACGIH)
Diethylamine, 2,2'-dihydroxy-
Diethylolamine
Diolamine
NCI-C55174
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 5500 mg | severe | AJOPAA 29,1363,1946 |
eye /rabbit | 750 µg/24H | severe | 85JCAE -,685,1986 |
skin /rabbit | 50 mg open irritation test | mild | UCDS** 12/29/1971 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,685,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
specific locus test | other cell types/human | 90 mg/L/16H (-enzymatic activation step) | MUREAV 724,76,2011 |
Unscheduled DNA Synthesis | liver/rat | 10 mg/L/24H | TOXID9 72,238,2003 |
Unscheduled DNA Synthesis | liver/mouse | 10 mg/L/24H | TOXID9 72,238,2003 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 200 mg/m3/6H (6-15D pregnant) | Reproductive: Other effects on female | NTIS** OTS0538412 |
oral/rat | 2800 mg/kg (6-19D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | BDERB* 74,243,2005 |
oral/rat | 1750 mg/kg (6-19D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Other postnatal measures or effects | BDERB* 74,243,2005 |
oral/rat | 18382 mg/kg (14D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTPTR* NIH-92-3343 |
skin/rat | 15 gm/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Other postnatal measures or effects | RTOPDW 30,169,1999 |
skin/rabbit | 4550 mg/kg (6-18D pregnant) | Reproductive: Other effects on female | RTOPDW 30,169,1999 |
skin/rat | 15000 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | RTOPDW 30,169,1999 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin/mouse | lowest published toxic dose: 21 gm/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTPTR* NTP-TR-478,1999 |
skin/mouse | lowest published toxic dose: 57680 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB99-167553 |
skin/mouse | lowest published toxic dose: 28840 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB99-167553 |
skin/mouse | lowest published toxic dose: 20857 mg/kg/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | CBINA8 146,251,2003 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 14 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): 26 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
intramuscular/rat | lethal dose (50 percent kill): 1500 mg/kg | EVSSAV 2,289,1968 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 210 mg/kg | NTIS** OTS0516742 | |
intraperitoneal/rat | lethal dose (50 percent kill): 120 mg/kg | EVSSAV 2,289,1968 | |
intravenous/rat | lethal dose (50 percent kill): 778 mg/kg | EVSSAV 2,289,1968 | |
oral/guinea pig | lethal dose (50 percent kill): 2 gm/kg | 85INA8 5,197,1986 | |
oral/mammal (species unspecified) | lowest published lethal dose: 3 gm/kg | NTIS** OTS0520710 | |
oral/mouse | lethal dose (50 percent kill): 3300 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Muscle contraction or spasticity | GISAAA 29(11),25,1964 |
oral/rabbit | lethal dose (50 percent kill): 2200 mg/kg | EVSSAV 2,289,1968 | |
oral/rat | lethal dose (50 percent kill): 620 µL/kg | Eye: Lacrimation Behavioral: Tremor Skin and Appendages: Other: Hair | NTIS** OTS0516797 |
skin/guinea pig | lethal dose (50 percent kill): 11900 µL/kg | NTIS** OTS0516742 | |
skin/rabbit | lethal dose (50 percent kill): 7640 µL/kg | Behavioral: Ataxia Musculoskeletal: Other changes Skin: After systemic exposure: Dermatitis, other | NTIS** OTS0516797 |
subcutaneous/rat | lethal dose (50 percent kill): 2200 mg/kg | EVSSAV 2,289,1968 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 400 mg/m3/6H/98D- intermittent | Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 400 mg/m3/6H/98D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Changes in erythrocyte (RBC) count | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 150 mg/m3/6H/98D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 150 mg/m3/6H/98D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 150 mg/m3/6H/98D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 15 mg/m3/6H/98D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 8 mg/m3/6H/103D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,2173,2008 |
inhalation/rat | lowest published toxic concentration: 8 mg/m3/6H/103D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,2173,2008 |
oral/mouse | lowest published toxic dose: 4800 mg/kg/8D- intermittent | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* IMM-9801 |
oral/mouse | lowest published toxic dose: 8400 mg/kg/14D- intermittent | Blood: Normocytic anemia Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count | NTPTR* IMM-9801 |
oral/mouse | lowest published toxic dose: 8400 mg/kg/14D- intermittent | Immunological Including Allergic: Increase in cellular immune response Immunological Including Allergic: Decrease in cellular immune response | NTPTR* IMM-9801 |
oral/mouse | lowest published toxic dose: 4200 mg/kg/14D- intermittent | Immunological Including Allergic: Decreased immune response | NTPTR* IMM-9801 |
oral/mouse | lowest published toxic dose: 30366 mg/kg/14D- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | NTPTR* NIH-92-3343 |
oral/mouse | lowest published toxic dose: 38402 mg/kg/13W- continuous | Cardiac: Changes in heart weight Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | NTPTR* NIH-92-3343 |
oral/rat | lowest published toxic dose: 52 gm/kg/14D- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Normocytic anemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | NTPTR* NIH-92-3343 |
oral/rat | lowest published toxic dose: 8827 mg/kg/13W- continuous | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Normocytic anemia Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-92-3343 |
oral/rat | lowest published toxic dose: 49 gm/kg/7W- continuous | Liver: Other changes Blood: Normocytic anemia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 17,308,1970 |
oral/rat | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB2001-103718 |
oral/rat | lowest published toxic dose: 2100 mg/kg/7D- intermittent | Behavioral: Sleep Behavioral: Tremor Skin and Appendages: Other: Hair | NTIS** #PB2001-103718 |
oral/rat | lowest published toxic dose: 500 mg/kg/4D- intermittent | Behavioral: Fluid intake | NTIS** #PB2001-103718 |
oral/rat | lowest published toxic dose: 1750 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight | NTIS** #PB2001-103718 |
oral/rat | lowest published toxic dose: 1400 mg/kg/7D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 74,243,2005 |
oral/rat | lowest published toxic dose: 800 mg/kg/4D- intermittent | Behavioral: Food intake (animal) | BDERB* 74,243,2005 |
oral/rat | lowest published toxic dose: 1000 mg/kg/4D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 74,243,2005 |
oral/rat | lowest published toxic dose: 875 mg/kg/7D- intermittent | Behavioral: Fluid intake | BDERB* 74,243,2005 |
oral/rat | lowest published toxic dose: 1600 mg/kg/8D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* IMM-20303 |
oral/rat | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Blood: Normocytic anemia Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count | NTPTR* IMM-20303 |
oral/rat | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Blood: Changes in cell count (unspecified) Immunological Including Allergic: Decrease in cellular immune response | NTPTR* IMM-20303 |
skin/mouse | lowest published toxic dose: 70 mg/kg/1W- intermittent | Liver: Changes in liver weight | FCTOD7 42,127,2004 |
skin/mouse | lowest published toxic dose: 910 mg/kg/13W- intermittent | Tumorigenic: Cells (cultured) transformed | FCTOD7 42,127,2004 |
skin/mouse | lowest published toxic dose: 280 mg/kg/1W- intermittent | Liver: Other changes | FCTOD7 42,127,2004 |
skin/mouse | lowest published toxic dose: 1120 mg/kg/1W- intermittent | Liver: Changes in liver weight Tumorigenic: Cells (cultured) transformed | FCTOD7 42,127,2004 |
skin/mouse | lowest published toxic dose: 4410 mg/kg/1W- intermittent | Skin: After topical application: Corrosive | FCTOD7 42,127,2004 |
skin/mouse | lowest published toxic dose: 1120 mg/kg/1W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | TOXID9 60,287,2001 |
skin/mouse | lowest published toxic dose: 30 gm/kg/16D- intermittent | Liver: Changes in liver weight Skin: After systemic exposure: Dermatitis, other Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NIH-92-3343 |
skin/mouse | lowest published toxic dose: 40950 mg/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | NTPTR* NIH-92-3343 |
skin/rat | lowest published toxic dose: 1008 mg/kg/16D- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Normocytic anemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | NTPTR* NIH-92-3343 |
skin/rat | lowest published toxic dose: 8125 mg/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Normocytic anemia | NTPTR* NIH-92-3343 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 101,136,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 101,136,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 77,564,2000 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 101,136,2013 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | ENTOX* -,266,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | TOPADD 33,517,2005 | |
TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
TOXICOLOGY REVIEW | MUREAV 566,49,2004 | |
TOXICOLOGY REVIEW | MUREAV 672,10,2009 | |
TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
TOXICOLOGY REVIEW | MUREAV 653,99,2008 | |
TOXICOLOGY REVIEW | EMMUEG 49,9,2008 | |
TOXICOLOGY REVIEW | MUREAV 786-788,14,2015 | |
TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
TOXICOLOGY REVIEW | MUREAV 795,7,2016 | |
TOXICOLOGY REVIEW | MUREAV 809,1,2016 | |
TOXICOLOGY REVIEW | RTOPDW 56,54,2010 | |
TOXICOLOGY REVIEW | RTOPDW 61,1,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHANOLAMINE-air | 10H time-weighted average 3 ppm | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code 24615; Number of Industries 249; Total Number of Facilities 46466; Number of Occupations 171; Total Number of Employees Exposed 828471; Total Number of Female Employees Exposed 218923 | |
National Occupational Hazard Survey 1974 | Hazard Code T0517; Number of Industries 3; Total Number of Facilities 315; Number of Occupations 2; Total Number of Employees Exposed 857 | |
National Occupational Hazard Survey 1974 | Hazard Code 24615; Number of Industries 147; Total Number of Facilities 18443; Number of Occupations 118; Total Number of Employees Exposed 186455 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health