Ethanol, 2-(diethylamino)-
RTECS #
KK5075000
CAS #
Updated
December 2018
Molecular Weight
117.22
Molecular Formula
C6H15NO
Synonyms
2-(Diethylamino)ethanol
2-Diethylaminoethanol
2-Diethylaminoethanol (ACGIH:OSHA)
2-Hydroxytriethylamine
2-N-Diethylaminoethanol
beta-Diethylaminoethanol
beta-Diethylaminoethyl alcohol
DEAE
Diaethylaminoaethanol (German)
Diethylethanolamine
N,N-Diethylethanolamine
N,N-Diethyl-N-(beta-hydroxyethyl)amine
N-Diethylaminoethanol
2-Diethylaminoethanol
2-Diethylaminoethanol (ACGIH:OSHA)
2-Hydroxytriethylamine
2-N-Diethylaminoethanol
beta-Diethylaminoethanol
beta-Diethylaminoethyl alcohol
DEAE
Diaethylaminoaethanol (German)
Diethylethanolamine
N,N-Diethylethanolamine
N,N-Diethyl-N-(beta-hydroxyethyl)amine
N-Diethylaminoethanol
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 5 mg | severe | UCDS** 6/11/1963 |
skin /rabbit | 10 mg/24H open irritation test | JIHTAB 26,269,1944 | |
skin /rabbit | 500 mg open irritation test | mild | UCDS** 6/11/1963 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Rabbit, ocular | Inhibitor Concentration Low: 5 pph/5M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 25,1425,2011 |
inhalation/human | lowest published toxic concentration: 200 ppm | Gastrointestinal: Nausea or vomiting | 34ZIAG -,216,1969 |
inhalation/mouse | lethal concentration (50 percent kill): 5000 mg/m3 | Brain and Coverings: Recordings from specific areas of CNS Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold | GTPZAB 14(11),52,1970 |
inhalation/rat | Lowest published lethal concentration: 4500 mg/m3/4H | Brain and Coverings: Recordings from specific areas of CNS Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold | GTPZAB 14(11),52,1970 |
intramuscular/mouse | lethal dose (50 percent kill): 416 mg/kg | ARZNAD 9,31,1959 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 192 mg/kg | Behavioral: Ataxia | JPETAB 94,249,1948 |
intraperitoneal/rat | lethal dose (50 percent kill): 1220 mg/kg | TXAPA9 12,486,1968 | |
intravenous/mouse | lethal dose (50 percent kill): 188 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes | ARZNAD 9,31,1959 |
oral/rat | lethal dose (50 percent kill): 1300 mg/kg | JIHTAB 26,269,1944 | |
skin/guinea pig | lethal dose (50 percent kill): 1 mL/kg | JIHTAB 26,269,1944 | |
skin/rabbit | lethal dose (50 percent kill): 1260 µL/kg | UCDS** 6/11/1963 | |
subcutaneous/mouse | lethal dose (50 percent kill): 650 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | ARZNAD 9,31,1959 |
unreported route/mammal (species unspecified) | lowest published lethal dose: 1300 mg/kg | 34ZIAG -,216,1969 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 500 ppm/6H/5D- intermittent | Eye: Other eye effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 26,479,1965 |
inhalation/rat | lowest published toxic concentration: 200 ppm/6H/26W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 26,479,1965 |
inhalation/rat | lowest published toxic concentration: 76 ppm/6H/14W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 18,418,1992 |
inhalation/rat | lowest published toxic concentration: 301 ppm/6H/2W- intermittent | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FAATDF 18,418,1992 |
oral/Dog | lowest published toxic dose: 21559 mg/kg/1Y- continuous | Brain and Coverings: Other degenerative changes Behavioral: Ataxia Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | NTIS** OTS0530455-1 |
oral/Dog | lowest published toxic dose: 4875 mg/kg/39D- intermittent | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0536945 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (50 mg/m3) (skin) | DTLVS* 3,85,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (48 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (24 mg/m3);KZW 5 ppm (24 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 2 ppm (9.7 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (9.6 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 10 ppm (49 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 10 ppm (50 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 5 ppm (24 mg/m3), 2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (9.6 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (50 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (50 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (48 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 2 ppm (9.6 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | time-weighted average 50 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (10 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (50 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 9.6 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 ppm (50 mg/m3), Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (50 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (50 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (50 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (50 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-DIETHYLAMINOETHANOL-air | 10H time-weighted average 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 24930; Number of Industries 115; Total Number of Facilities 11825; Number of Occupations 68; Total Number of Employees Exposed 106878; Total Number of Female Employees Exposed 20564 | |
National Occupational Hazard Survey 1974 | Hazard Code 24930; Number of Industries 71; Total Number of Facilities 7801; Number of Occupations 39; Total Number of Employees Exposed 23770 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health