Ethane, 1,1,2-trichloro-1,2,2-trifluoro-
RTECS #
KJ4000000
CAS #
Updated
September 2013
Molecular Weight
187.37
Molecular Formula
C2Cl3F3
Synonyms
1,1,2-Trichloro-1,2,2-trifluoroethane
1,1,2-Trichloro-1,2,2-trifluoroethane (ACGIH:OSHA)
1,1,2-Trichlorotrifluoroethane
1,1,2-Trifluoro-1,2,2-trichloroethane
1,1,2-Trifluorotrichloroethane
1,2,2-Trichlorotrifluoroethane
Arcton 63
Arklone P
Asahifron 113
CFC-113
Chlorofluorethane
Chlorofluorocarbon 113
Daiflon S 3
F 113
FC 113
Fluorocarbon 113
Freon 113
Freon 113, commercial grade
Freon 113, contaminated
Freon 113, specially purified
Freon 113TR-T
Freon F113
Freon TF
Freon-TF
Frigen 113
Frigen 113 TR-T
Frigen 113a
Frigen 113TR
Frigen 113TR-N
Genetron 113
Halocarbon 113
Isceon 113
Kaiser chemicals 11
Khladon 113
Ledon 113
R 113
R 113 (Halocarbon)
Racon 113
Refrigerant 113
Refrigerant R 113
1,1,2-Trichloro-1,2,2-trifluoroethane (ACGIH:OSHA)
1,1,2-Trichlorotrifluoroethane
1,1,2-Trifluoro-1,2,2-trichloroethane
1,1,2-Trifluorotrichloroethane
1,2,2-Trichlorotrifluoroethane
Arcton 63
Arklone P
Asahifron 113
CFC-113
Chlorofluorethane
Chlorofluorocarbon 113
Daiflon S 3
F 113
FC 113
Fluorocarbon 113
Freon 113
Freon 113, commercial grade
Freon 113, contaminated
Freon 113, specially purified
Freon 113TR-T
Freon F113
Freon TF
Freon-TF
Frigen 113
Frigen 113 TR-T
Frigen 113a
Frigen 113TR
Frigen 113TR-N
Genetron 113
Halocarbon 113
Isceon 113
Kaiser chemicals 11
Khladon 113
Ledon 113
R 113
R 113 (Halocarbon)
Racon 113
Refrigerant 113
Refrigerant R 113
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg open irritation test | mild | UCDS** 7/10/1970 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,137,1986 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rabbit | 20 ppm (8-16D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Physical | EPASR* #86-890000920S |
oral/rabbit | 5 gm/kg (8D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death | NTIS** OTS0571230 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lethal concentration (50 percent kill): >12 pph/2H | AMPMAR 29,381,1968 | |
inhalation/guinea pig | Lowest published lethal concentration: 4 pph/60M | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | TJIDAH 95,1283,1980 |
inhalation/human | lowest published toxic concentration: 2500 ppm/90M | Behavioral: Change in psychophysiological tests | AIHAAP 28,43,1967 |
inhalation/mouse | Lowest published lethal concentration: 230000 mg/m3/2H | VCVGH* -,636,1990 | |
inhalation/mouse | lowest published toxic concentration: 393000 mg/m3/1H | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: General anesthetic | VCVGH* -,636,1990 |
inhalation/mouse | lethal concentration (50 percent kill): 260 gm/m3/2H | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis | TLSMA6 75,241,1963 |
inhalation/rabbit | lethal concentration (50 percent kill): 59500 ppm/2H | Eye: Other eye effects Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory stimulation | NTIS** OTS0520343 |
inhalation/rabbit | Lowest published lethal concentration: 55120 ppm/2H | Eye: Lacrimation Gastrointestinal: Changes in structure or function of salivary glands | EPASR* #86-890000904S |
inhalation/rabbit | lethal concentration (50 percent kill): 59500 ppm/2H | Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Respiratory obstruction | EPASR* #86-890000904S |
inhalation/rat | Lowest published lethal concentration: 57500 ppm/4H | Behavioral: Tremor Behavioral: Excitement | EPASR* #86-890000906S |
inhalation/rat | Lowest published lethal concentration: 37000 ppm/4H | Behavioral: Tremor Behavioral: Ataxia | EPASR* #86-890000902S |
inhalation/rat | lethal concentration (50 percent kill): 38000 ppm/4H | EPASR* #86-890000902S | |
inhalation/rat | Lowest published lethal concentration: 786000 mg/m3/4H | VCVGH* -,636,1990 | |
inhalation/rat | lethal concentration (50 percent kill): 38500 ppm/4H | Behavioral: General anesthetic Behavioral: Excitement Behavioral: Ataxia | NTIS** OTS0520341 |
intraperitoneal/mouse | lowest published toxic dose: 23200 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | ENVRAL 45,101,1988 |
intravenous/mouse | lethal dose (50 percent kill): 9 gm/kg | Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Altered sleep time (including change in righting reflex) Skin: After systemic exposure: Dermatitis, other | NTIS** OTS0520355 |
oral/guinea pig | Lethal dose: >10 gm/kg | NTIS** OTS0520705 | |
oral/rabbit | lowest published lethal dose: 17 gm/kg | AIHAAP 29,521,1968 | |
oral/rat | lethal dose (50 percent kill): 43 gm/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Skin and Appendages: Other: Hair | JMCMAR 7,378,1964 |
oral/rat | lethal dose (50 percent kill): 43 gm/kg | Behavioral: General anesthetic | VCVGH* -,636,1990 |
skin/rabbit | Lethal dose: >11 gm/kg | AIHAAP 29,521,1968 | |
unreported route/mouse | lethal dose (50 percent kill): 40 gm/kg | USXXAM #4164653 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 70000 mg/m3/4H/16W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VCVGH* -,636,1990 |
inhalation/human | lowest published toxic concentration: 4300 mg/m3/5D- intermittent | Brain and Coverings: Recordings from specific areas of CNS | VCVGH* -,637,1990 |
inhalation/human | lowest published toxic concentration: 178 mg/m3/10Y- intermittent | Behavioral: Headache | VCVGH* -,637,1990 |
inhalation/rat | lowest published toxic concentration: 20 pph/6H/2Y- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 11,68,1988 |
inhalation/rat | lowest published toxic concentration: 2000 ppm/6H/2W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXCYAC 18,17,1980 |
inhalation/rat | lowest published toxic concentration: 17500 ppm/6H/13W - intermittent | Lung, Thorax, or Respiration: Changes in lung weight | EPASR* #86-890000892S |
inhalation/rat | lowest published toxic concentration: 20000 ppm/6H/13W - intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight | EPASR* #86-890000892S |
multiple/guinea pig | lowest published toxic concentration: 60 mL/kg/3W- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TJIDAH 95,1283,1980 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1000 ppm;short term exposure limit 1250 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FAZMAE 18,365,1974 | |
TOXICOLOGY REVIEW | AIHAAP 29,521,1968 | |
TOXICOLOGY REVIEW | ENTOX* -,384,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,577,1996 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1000 ppm (7600 mg/m3) | DTLVS* 3,267,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 500 ppm (3800 mg/m3);KZW 1000 ppm (7600 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 1000 ppm (7781 mg/m3), MAR2002 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 1250 ppm (9729 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 500 ppm (3800 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 1000 ppm (7800 mg/m3), short term exposure limit 1300 ppm (10000 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 1000 ppm (7600 mg/m3), VLE 1250 ppm (9500 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 500 ppm (3900 mg/m3), 2011 | |
Occupational Exposure Limit-HUNGARY | Prohibited in Hungary, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 500 ppm (3800 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 500 ppm (3800 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm (9500 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 1000 ppm (1600 mg/m3);short term exposure limit 1250 ppm, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 500 ppm (3800 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 1000 ppm (7665 mg/m3); short term exposure limit 1250 ppm (9581 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5000 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 500 ppm (4000 mg/m3);short term exposure limit 750 ppm (6000 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 500 ppm (3800 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1170 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1000 ppm (7600 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 1000 ppm (7600 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1000 ppm (7600 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1000 ppm (7600 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1000 ppm (7600 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1000 ppm (7600 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air | 10H time-weighted average 1000 ppm;short term exposure limit 1250 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 74010; Number of Industries 119; Total Number of Facilities 12471; Number of Occupations 103; Total Number of Employees Exposed 250773; Total Number of Female Employees Exposed 79790 | |
National Occupational Hazard Survey 1974 | Hazard Code 74010; Number of Industries 175; Total Number of Facilities 19387; Number of Occupations 103; Total Number of Employees Exposed 282795 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health