Ethane, 1,1,2-trichloro-
RTECS #
KJ3150000
CAS #
Updated
March 2018
Molecular Weight
133.40
Molecular Formula
C2H3Cl3
Synonyms
1,1,2-Trichlorethane
1,1,2-Trichloroethane
1,1,2-Trichloroethane (ACGIH:OSHA)
1,2,2-Trichloroethane
beta-T
beta-Trichloroethane
Ethane trichloride
NCI-C04579
RCRA waste number U227
RCRA waste number U359
Trojchloroetan(1,1,2) (Polish)
Vinyl trichloride
1,1,2-Trichloroethane
1,1,2-Trichloroethane (ACGIH:OSHA)
1,2,2-Trichloroethane
beta-T
beta-Trichloroethane
Ethane trichloride
NCI-C04579
RCRA waste number U227
RCRA waste number U359
Trojchloroetan(1,1,2) (Polish)
Vinyl trichloride
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 162 mg | mild | EJTXAZ 9,171,1976 |
eye /rabbit | 500 mg/24H | mild | 85JCAE -,95,1986 |
skin /guinea pig | 1440 mg/15M | APTOA6 41,298,1977 | |
skin /rabbit | 500 mg open irritation test | mild | UCDS** 6/28/1972 |
skin /rabbit | 810 mg/24H | severe | EJTXAZ 9,171,1976 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,95,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | skin/guinea pig | 2880 µg/kg | APTOA6 41,298,1977 |
DNA adduct | lymphocyte/mammal (species unspecified) | 1 mmol/L | TOLED5 11,243,1982 |
DNA Damage | lymphocyte/human | 2500 µmol/L | MUREAV 371,185,1996 |
micronucleus test | lymphocyte/human | 100 µmol/L | MUREAV 371,185,1996 |
morphological transform | embryo/mouse | 25 mg/L | CALEDQ 28,85,1985 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate (+/-enzymatic activation step) | TECSDY 15,101,1987 |
other mutation test systems | /Escherichia coli | 135 mmol/L | EMMUEG 19,98,1992 |
other mutation test systems | oral/mouse | 100 mg/kg | MUREAV 343,157,1995 |
sex chromosome loss and nondisjunction | /Aspergillus nidulans | 750 ppm | MUREAV 201,401,1988 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 76 gm/kg/78W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Adrenal cortex tumors | NCITR* NCI-TR-74,1978 |
oral/mouse | toxic dose: 152 gm/kg/78W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Adrenal cortex tumors | NCITR* NCI-TR-74,1978 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Mouse, liver | Inhibitor Concentration (50 percent kill): 5.6 mmol/L/2H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 3,145,1989 |
In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 5.2 mmol/L/2H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 3,145,1989 |
inhalation/cat | Lowest published lethal concentration: 13100 mg/m3/4.5H | Eye: Other eye effects Behavioral: General anesthetic Gastrointestinal: Changes in structure or function of salivary glands | AHBAAM 116,131,1936 |
inhalation/mouse | lowest published toxic concentration: 20400 mg/m3/17M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | VCVGH* -,381,1990 |
inhalation/mouse | lowest published toxic concentration: 10000 mg/m3/2H | Behavioral: General anesthetic | VCVGH* -,380,1990 |
inhalation/rat | Lowest published lethal concentration: 500 ppm/4H | UCDS** 6/28/1972 | |
intraperitoneal/Dog | lethal dose (50 percent kill): 450 mg/kg | Liver: Liver function tests impaired | TXAPA9 10,119,1967 |
intraperitoneal/guinea pig | lowest published lethal dose: 970 mg/kg | AOHYA3 19,115,1976 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 494 mg/kg | TXAPA9 9,139,1966 | |
intraperitoneal/rat | lethal dose (50 percent kill): 265 mg/kg | ENVRAL 40,411,1986 | |
intravenous/Dog | lowest published lethal dose: 95 mg/kg | QJPPAL 7,205,1934 | |
oral/Dog | lowest published lethal dose: 500 mg/kg | Behavioral: Sleep Liver: Hepatitis (hepatocellular necrosis), zonal | AJHYA2 16,325,1932 |
oral/mouse | lethal dose (50 percent kill): 378 mg/kg | VCVGH* -,381,1990 | |
oral/mouse | lethal dose (50 percent kill): 378 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Gastrointestinal: Ulceration or bleeding from stomach | DCTODJ 8,333,1985 |
oral/rat | lethal dose (50 percent kill): 580 mg/kg | ENTOX* -,380,2005 | |
skin/guinea pig | lowest published lethal dose: 970 mg/kg | AOHYA3 19,115,1976 | |
skin/rabbit | lethal dose (50 percent kill): 3730 µL/kg | AIHAAP 30,470,1969 | |
subcutaneous/mouse | lethal dose (50 percent kill): 227 mg/kg | JPETAB 123,224,1958 | |
subcutaneous/rabbit | lowest published lethal dose: 500 mg/kg | QJPPAL 7,205,1934 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 532 mg/kg/14D- intermittent | Brain and Coverings: Changes in brain weight Endocrine: Changes in thymus weight Related to Chronic Data: Changes in testicular weight | DCTODJ 8,333,1985 |
oral/mouse | lowest published toxic dose: 27 gm/kg/90D- continuous | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | DCTODJ 8,333,1985 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 20,533,1979 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 52,337,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 71,1153,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 20,533,1979 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Available Data | IMEMDT 52,337,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1153,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1153,1999 |
TOXICOLOGY REVIEW | FAZMAE 18,365,1974 | |
TOXICOLOGY REVIEW | AIHAAP 40(3),A46,1979 | |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
TOXICOLOGY REVIEW | ENTOX* -,380,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
TOXICOLOGY REVIEW | MUTAEX 32,491,2017 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (45 mg/m3) (skin) | DTLVS* 3,263,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 10 ppm (40 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (55 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 ppm (55 mg/m3);KZW 50 ppm (275 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (56 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (54 mg/m3), skin, carc, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 10 ppm (55 mg/m3), short term exposure limit 20 ppm (110 mg/m3), NOV2011 | |
Occupational Exposure Limit-GERMANY | MAK 10 ppm (55 mg/m3), skin, 2011 | |
Occupational Exposure Limit-HUNGARY | Prohibited in Hungary, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (54 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 10 ppm (55 mg/m3), skin, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (55 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (45 mg/m3);short term exposure limit 20 ppm (30 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (55 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (54 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 10 ppm (55 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 10 ppm, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (55 mg/m3), KZG-week 20 ppm (110 mg/m3), carc 3, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 45 mg/m3, Skin, 2003 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (45 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (45 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (45 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (45 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2-TRICHLOROETHANE-air | 10H Carcinogen time-weighted average 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 73770; Number of Industries 4; Total Number of Facilities 95; Number of Occupations 12; Total Number of Employees Exposed 1038; Total Number of Female Employees Exposed 16 | |
National Occupational Hazard Survey 1974 | Hazard Code 73770; Number of Industries 12; Total Number of Facilities 1422; Number of Occupations 18; Total Number of Employees Exposed 10453 |
Status in Federal Agencies
Organization | Reference |
---|---|
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/196411/AS) | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse | NCITR* NCI-TR-74,1978 |
NCI Carcinogenesis Bioassay (gavage);no evidence:rat | NCITR* NCI-TR-74,1978 |
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003 | |
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978 | |
On EPA IRIS database | |
OSHA ANALYTICAL METHOD #11 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health