Ethane, 1,1,2,2-tetrabromo-

RTECS #

KI8225000

CAS #

79-27-6
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

345.68

Molecular Formula

C₂H₂Br₄

Synonyms

1,1,2,2-Tetrabromaethan (German)
1,1,2,2-Tetrabromoetano (Italian)
1,1,2,2-Tetrabromoethane
1,1,2,2-Tetrabroomethaan (Dutch)
Acetylene tetrabromide
Acetylene tetrabromide (ACGIH:OSHA)
Muthmann's liquid
s-Tetrabromoethane
TBE
Tetrabromoacetylene

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	mild	AIHAAP 24,28,1963
skin /rabbit	500 mg/24H	moderate	AIHAAP 24,28,1963

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA repair	/Escherichia coli	29640 µg/disc	MUREAV 41,61,1976
mutation in microorganisms	/Salmonella typhimurium	10 µg/plate (+/-enzymatic activation step)	TECSDY 15,101,1987
sister chromatid exchange	ovary/hamster	158 mg/L	EMMUEG 10(Suppl 10),1,1987

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
skin/mouse	lowest published toxic dose: 130 gm/kg/74W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors	JJIND8 63,1433,1979

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 500 mg/m³/3H	Behavioral: General anesthetic	VCVGH* -,591,1990
inhalation/rat	lethal concentration (50 percent kill): 549 mg/m³/4H		85GMAT -,107,1982
inhalation/rat	lethal concentration (50 percent kill): 550 mg/m³		VCVGH* -,572,1990
intraperitoneal/mouse	lethal dose (50 percent kill): 443 mg/kg		ABMGAJ 41,945,1982
oral/guinea pig	lethal dose (50 percent kill): 400 mg/kg		AIHAAP 30,251,1969
oral/mouse	lethal dose (50 percent kill): 269 mg/kg		85GMAT -,107,1982
oral/rabbit	lethal dose (50 percent kill): 400 mg/kg	Behavioral: General anesthetic Liver: Fatty liver degeneration Blood: Hemorrhage	AMIHBC 2,407,1950
oral/rat	lethal dose (50 percent kill): 1200 mg/kg		VCVGH* -,572,1990
skin/rat	lethal dose (50 percent kill): 5250 mg/kg		85GMAT -,107,1982

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 14 ppm/7H/14W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 24,28,1963
inhalation/guinea pig	lowest published toxic concentration: 4 ppm/7H/26W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AIHAAP 24,28,1963
inhalation/mouse	lowest published toxic concentration: 14 ppm/7H/15W- intermittent	Liver: Changes in liver weight	AIHAAP 24,28,1963
inhalation/rabbit	lowest published toxic concentration: 14 ppm/7H/15W- intermittent	Liver: Changes in liver weight	AIHAAP 24,28,1963
inhalation/rat	lowest published toxic concentration: 100 mg/m³/4H/17W- intermittent	Liver: Liver function tests impaired Liver: Changes in liver weight Blood: Hemorrhage	VRDEA5 (3),80,1967
inhalation/rat	lowest published toxic concentration: 14 ppm/7H/14W- intermittent	Liver: Changes in liver weight	AIHAAP 24,28,1963
inhalation/rat	lowest published toxic concentration: 4 ppm/7H/26W- intermittent	Liver: Changes in liver weight	AIHAAP 24,28,1963
oral/rat	lowest published toxic dose: 10920 mg/kg/13W- intermittent	Liver: Liver function tests impaired Liver: Changes in liver weight Blood: Other changes	VRDEA5 (3),80,1967
oral/rat	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Blood: Other changes	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 2800 mg/kg/14D- intermittent	Blood: Other changes Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 2800 mg/kg/14D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 700 mg/kg/14D- intermittent	Liver: Changes in liver weight	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 5600 mg/kg/28D- intermittent	Endocrine: Other changes Blood: Changes in platelet count	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 560 mg/kg/28D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 560 mg/kg/28D- intermittent	Liver: Other changes	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 5600 mg/kg/28D- intermittent	Endocrine: Other changes	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 3600 mg/kg/18D- intermittent	Lung, Thorax, or Respiration: Respiratory depression Liver: Changes in liver weight Endocrine: Changes in spleen weight	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 3600 mg/kg/18D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight	JTSCDR 30,29,2005
oral/rat	lowest published toxic dose: 1600 mg/kg/8D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 30,29,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm (inhal, vapor)	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (14 mg/m³)	DTLVS* 3,248,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (14 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1 ppm (14 mg/m³);KZW 4 ppm (56 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (14 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (14 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 ppm (7 mg/m³), short term exposure limit 3 ppm (43 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (15 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (14 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (15 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (15 mg/m³);short term exposure limit 1.5 ppm (20 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (14 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (14 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (14 mg/m³);short term exposure limit 2 ppm (30 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (14 mg/m³), KZG-week 2 ppm (28 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 7 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 ppm (14 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1 ppm (14 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.5 ppm (7.2 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 ppm (14 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1 ppm (14 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1 ppm (14 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 ppm (14 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 71401; Number of Industries 5; Total Number of Facilities 172; Number of Occupations 5; Total Number of Employees Exposed 2516
National Occupational Hazard Survey 1974	Hazard Code 71401; Number of Industries 2; Total Number of Facilities 39; Number of Occupations 3; Total Number of Employees Exposed 440

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrabromoethane, 2003
NTP Toxicity studies, RPT# TOX-45, October 2000

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health