Ethane, pentachloro-

RTECS #

KI6300000

CAS #

76-01-7
See: NMAM or OSHA Methods

Updated

April 2017

Molecular Weight

202.28

Molecular Formula

C₂HCl₅

Synonyms

Ethane pentachloride
NCI-C53894
Pentachloorethaan (Dutch)
Pentachloraethan (German)
Pentachlorethane (French)
Pentachloroethane
Pentacloroetano (Italian)
Pentalin
RCRA waste number U184

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	80 mg/L	MUREAV 369,243,1996
mutation in mammalian somatic cells	lymphocyte/mouse	70 mg/L	EMMUEG 12,85,1988
mutation in microorganisms	/Saccharomyes cerevisiae	2500 µmol/L (+enzymatic activation step)	TCMUD8 9,349,1989
other mutation test systems	oral/mouse	500 mg/kg	MUREAV 343,157,1995
other mutation test systems	/Escherichia coli	25814 µmol/L	EMMUEG 19,98,1992
sex chromosome loss and nondisjunction	lung/human	80 mg/L	MUREAV 369,243,1996
sister chromatid exchange	ovary/hamster	100 mg/L	SCIEAS 236,933,1987

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 71750 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB83-206748
oral/rat	lowest published toxic dose: 108150 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTIS** PB83-206748

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 17 mg/m³	Behavioral: General anesthetic	VCVGH* -,390,1990
inhalation/mouse	lowest published toxic concentration: 7500 mg/m³/2H	Behavioral: General anesthetic	VCVGH* -,307,1990
inhalation/mouse	Lowest published lethal concentration: 35000 mg/m³/2H		VCVGH* -,390,1990
inhalation/rat	lethal concentration (50 percent kill): 4238 ppm/2H		85JCAE -,97,1986
intravenous/Dog	lowest published lethal dose: 100 mg/kg		QJPPAL 7,205,1934
oral/Dog	lowest published lethal dose: 500 mg/kg	Behavioral: Sleep Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration	AJHYA2 16,325,1932
oral/rat	lethal dose (50 percent kill): 920 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Liver: Other changes	SRTCAC 36(1-4),10,1989
subcutaneous/rabbit	lowest published lethal dose: 700 mg/kg		QJPPAL 7,205,1934

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 32500 mg/kg/13W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-232,1982
oral/mouse	lowest published toxic dose: 14 gm/kg/14D- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-232,1982
oral/rat	lowest published toxic dose: 7 gm/kg/14D- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-232,1982

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,1519,1999
TOXICOLOGY REVIEW		AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW		MUTAEX 14,5,1999
TOXICOLOGY REVIEW		MUTAEX 14,271,1999
TOXICOLOGY REVIEW		MUREAV 628,67,2007
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (40 mg/m³);KZW 20 ppm (160 mg/m³), 2007
Occupational Exposure Limit-DENMARK	time-weighted average 5 ppm (40 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 ppm (42 mg/m³), short term exposure limit 10 ppm (84 mg/m³), NOV2011
Occupational Exposure Limit-GERMANY	MAK 5 ppm (42 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 5 ppm (40 mg/m³), skin, NOV2011
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (40 mg/m³), JAN1999
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (40 mg/m³), KZG-week 10 ppm (80 mg/m³), carc 3, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 40 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 5 ppm (40 mg/m³), JAN1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROETHANE-air	Handle with caution	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X6173; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 232; Total Number of Female Employees Exposed 3

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NIOSH Analytical Method, 1994: Pentachloroethane, 2517
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NTP Toxicity studies, RPT# TOX-45, October 2000
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health