1,2-Ethanediamine

RTECS #

KH8575000

CAS #

107-15-3
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

60.12

Molecular Formula

C₂H₈N₂

Synonyms

1,2-Diaminoaethan (German)
1,2-Diamino-ethaan (Dutch)
1,2-Diaminoethane (OSHA)
1,2-Diamino-ethano (Italian)
1,2-Ethylenediamine
Aethaldiamin (German)
Aethylenediamin (German)
Dimethylenediamine
Ethyleendiamine (Dutch)
Ethylendiamine
Ethylenediamine
Ethylenediamine (ACGIH:OSHA)
Ethylene-diamine (French)
NCI-C60402

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	750 µg	severe	AJOPAA 29,1363,1946
eye /rabbit	750 µg/24H	severe	85JCAE -,440,1986
skin /rabbit	450 mg open irritation test	moderate	UCDS** 12/15/1971
skin /rabbit	10 mg/24H open irritation test	severe	AMIHBC 4,119,1951

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	33 µg/plate (+enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	3200 mg/kg (6-13D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TCMUD8 7,29,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, leukemia cells	Inhibitor Concentration (5 percent kill): 69.1 mg/L/30M	In Vitro Toxicity Studies: Cell counting	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 54.9 mg/L/30M	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (25 percent kill): 271.7 mg/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 26,1150,2012
In Vitro/Human, leukemia cells	Inhibitor Concentration (50 percent kill): 265.7 mg/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 26,1150,2012
In Vitro/Human, lung	Inhibitor Concentration (20 percent kill): >4 mmol/L	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 30,274,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (30 percent kill): 58 mg/L/45H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (50 percent kill): 16 mg/L/45H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,901,2015
In Vitro/Human, monocyte	Inhibitor Concentration Low: 467 mg/L/2H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1233,2013
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXAPA9 245,281,2010
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 99.9 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TXAPA9 245,281,2010
In Vitro/jrd	Inhibitor Concentration (50 percent kill): 132.8 mg/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 28,626,2014
inhalation/human	lowest published toxic concentration: 200 ppm	Peripheral Nerve and Sensation: Paresthesia	AMIHBC 9,223,1954
inhalation/mouse	lethal concentration (50 percent kill): 300 mg/m³		85GMAT -,66,1982
inhalation/rat	Lowest published lethal concentration: 4000 ppm/8H		AMIHBC 4,119,1951
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		CHTPBA 4,136,1969
intraperitoneal/rat	lethal dose (50 percent kill): 76 mg/kg		TXAPA9 21,454,1972
intravenous/Dog	lowest published lethal dose: 100 mg/kg		HBAMAK 4,1295,1935
oral/guinea pig	lethal dose (50 percent kill): 470 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes	JIHTAB 23,259,1941
oral/mouse	lethal dose (50 percent kill): 1 gm/kg	Behavioral: Ataxia	MTPEEI (1),38,1997
oral/rat	lethal dose (50 percent kill): 1200 mg/kg	Behavioral: Ataxia	MTPEEI (1),38,1997
skin/rabbit	lethal dose (50 percent kill): 730 µL/kg		AMIHBC 4,119,1951
subcutaneous/rabbit	lowest published lethal dose: 500 mg/kg		HBAMAK 4,1295,1935
subcutaneous/rat	lethal dose (50 percent kill): 300 mg/kg		85GMAT -,66,1982

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic dose: 700 µg/m³/17W- intermittent	Brain and Coverings: Other degenerative changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	VMDKAM 38(2),1932
inhalation/rat	lowest published toxic concentration: 225 ppm/7H/30D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 9,223,1954
oral/rabbit	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** #PB93-190056
oral/rat	lowest published toxic dose: 540 mg/kg/6W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Other changes in urine composition	MTPEEI (1),38,1997
oral/rat	lowest published toxic dose: 3500 mg/kg/7D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0571059
oral/rat	lowest published toxic dose: 39 gm/kg/13W- intermittent	Eye: Other eye effects Blood: Hemorrhage Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0536438

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JJOMDZ 15,808,1973
TOXICOLOGY REVIEW		CHHSA* 9,6,2002
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		DERCL* 27,289,2009
TOXICOLOGY REVIEW		TXAPA9 243,225,2010
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (25 mg/m³)	DTLVS* 3,109,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (25 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 ppm (25 mg/m³);KZW 40 ppm (100 mg/m³), skin, sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 ppm (25 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 ppm (25 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 ppm (25 mg/m³), short term exposure limit 20 ppm (50 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (25 mg/m³), VLE 15 ppm (35 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (25 mg/m³), sen, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 10 ppm (25 mg/m³), skin, a2 sen, s2 sen, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (25 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (25 mg/m³);short term exposure limit 3 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (25 mg/m³), skin, sen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (25 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 10 ppm (25 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 2 mg/m³, MAC(short term exposure limit) 6 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (25 mg/m³);short term exposure limit 15 ppm (35 mg/m³), Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (25 mg/m³), KZG-week 20 ppm (50 mg/m³), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 18 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 ppm (25 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 10 ppm (25 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (25 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (25 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (25 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (25 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEDIAMINE-air	10H time-weighted average 10 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 32220; Number of Industries 77; Total Number of Facilities 6260; Number of Occupations 85; Total Number of Employees Exposed 113007; Total Number of Female Employees Exposed 29888
National Occupational Hazard Survey 1974	Hazard Code 32220; Number of Industries 33; Total Number of Facilities 2126; Number of Occupations 35; Total Number of Employees Exposed 15918

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylenediamine, 2540
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-60

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health