Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-

RTECS #

KH6550000

CAS #

151-67-7
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

197.39

Molecular Formula

C₂HBrClF₃

Synonyms

1,1,1-Trifluoro-2-bromo-2-chloroethane
1,1,1-Trifluoro-2-chloro-2-bromoethane
1-Bromo-1-chloro-2,2,2-trifluoroethane
2,2,2-Trifluoro-1-chloro-1-bromoethane
2-Bromo-2-chloro-1,1,1-trifluoroethane
Bromochlorotrifluoroethane
Chalothane
Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
Fluorotane
Fluothane
Ftorotan (Russian)
Halotan
Halothane
Halothane (ACGIH)
Halsan
Narcotane
Narcotann NE-spofa (Russian)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	severe	FEPRA7 35,729,1976

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	1 pph/48H-continuous	NSMZDZ 7,19,1979
Cytogenetic Analysis	fibroblast/mouse	1000 ppm	ENVRAL 12,366,1976
Cytogenetic Analysis	lung/hamster	1 pph/48H-continuous	NSMZDZ 7,19,1979
Cytogenetic Analysis	parenteral/chicken	10 mg	ENVRAL 12,366,1976
DNA inhibition	inhalation/mouse	8000 ppm/24H-continuous	CNREA8 36,3156,1976
micronucleus test	oral/rat	4 mmol/kg	MUREAV 413,1,1998
other mutation test systems	inhalation/grasshopper	46 pph/16H	MUREAV 113,467,1983
other mutation test systems	other cell types/non-mammalian species	1 mmol/L	ECREAL 141,492,1982
other mutation test systems	inhalation/mouse	1 pph/1H	BCPCA6 27,2187,1978
other mutation test systems	fibroblast/hamster	1 pph	ANESAV 43,21,1975
sex chromosome loss and nondisjunction	inhalation/Drosophila melanogaster	1 pph/1H	ANESAV 62,305,1985
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	3450 ppm/24H-continuous	MUREAV 91,225,1981
Unscheduled DNA Synthesis	inhalation/rat	1000 ppm/2H-continuous	ANESAV 30,401,1969
Unscheduled DNA Synthesis	oral/rat	10 gm/kg	JTEHD6 10,327,1982

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	100 ppm/8H (2-22D preg/30D after birth)	Reproductive: Effects on newborn: Behavioral	BBREDI 36,147,1990
inhalation/rat	8000 ppm/12H (9D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	ANESAV 29,1167,1968
inhalation/rat	1600 ppm/8H (1-21D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ANESAV 48,11,1978
inhalation/rat	10 ppm/8H (1-22D pregnant)	Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) Reproductive: Specific developmental abnormalities: Central nervous system	ENVRAL 11,40,1976
inhalation/rat	8000 ppm/6H (7-9D pregnant)	Reproductive: Effects on fertility: Abortion	AAREAV 32,41,1975
inhalation/rat	10 ppm/8H (1-22D pregnant)	Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) Reproductive: Specific developmental abnormalities: Urogenital system	ENVRAL 10,174,1975
inhalation/mouse	3000 ppm/4H (9W prior to copulation/1-21D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on fertility: Other measures of fertility	ANESAV 48,167,1978
inhalation/mouse	1000 ppm/4H (9W prior to copulation/1-21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	ANESAV 48,167,1978
inhalation/mouse	1 pph/3H (13D pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities	TJADAB 4,242,1971
inhalation/mouse	3000 ppm/4H (9W prior to copulation/1-17D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system	ANESAV 51,532,1979
inhalation/mouse	14000 ppm/1H (8-10D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	DABBBA 31,3599,1970
inhalation/mouse	15000 ppm/40M (3W prior to copulation)	Reproductive: Other effects on female Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Other postnatal measures or effects	REPTED 13,361,1999

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/child	lowest published toxic concentration: 0.9 pph	Cardiac: Change in rate Lung, Thorax, or Respiration: Respiratory depression Biochemical: Metabolism (intermediary): Other	AANEAB 45,639,2001
inhalation/human	Lowest published lethal concentration: 7000 ppm/3H	Liver: Hepatitis (hepatocellular necrosis), diffuse Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Body temperature increase	ANESAV 24,29,1963
inhalation/mouse	lethal concentration (50 percent kill): 98 gm/m³/2H	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	TLSMA6 111,10,1975
inhalation/mouse	lethal concentration (50 percent kill): 93600 mg/m³/2H		VCVGH* -,644,1990
inhalation/mouse	lethal concentration (50 percent kill): 340575 mg/m³/10M		VCVGH* -,644,1990
inhalation/mouse	lethal concentration (50 percent kill): 270662 mg/m³/30M		VCVGH* -,644,1990
inhalation/mouse	lethal concentration (50 percent kill): 197421 mg/m³/60M		VCVGH* -,644,1990
inhalation/mouse	lowest published toxic concentration: 1.21 pph/20M	Behavioral: Analgesia	JPETAB 317,615,2006
inhalation/mouse	lowest published toxic concentration: 2960.85 mg/kg	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	TOXID9 -,174,2008
inhalation/mouse	lowest published toxic concentration: 1.35 pph/20M	Behavioral: General anesthetic	JPETAB 323,924,2007
inhalation/rat	lowest published toxic concentration: 10 ppm/2H	Liver: Multiple effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other	TOXID9 227,53,2006
inhalation/rat	lethal concentration (50 percent kill): 120000 mg/m³/4H		VCVGH* -,644,1990
inhalation/rat	lowest published toxic concentration: 1.5 pph/30M	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other	AANEAB 46,378,2002
inhalation/rat	lethal concentration (50 percent kill): 29000 ppm		FATOAO 25,143,1962
inhalation/rat	lowest published toxic concentration: 1.5 pph	Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	FATOAO 55,33,1992
intraperitoneal/guinea pig	lowest published toxic dose: 1.97 gm/kg	Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	CRTOEC 14,362,2001
intraperitoneal/guinea pig	lowest published toxic dose: 1974 mg/kg	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	TOLED5 144,35,2003
intraperitoneal/guinea pig	lowest published toxic dose: 1974 mg/kg	Liver: Liver function tests impaired Liver: Other changes Biochemical: Metabolism (intermediary): Other	TOXID9 1,87,2001
intraperitoneal/mouse	lowest published toxic dose: 5921.7 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Liver: Other changes	TXCYAC 319,75,2014
intraperitoneal/mouse	lowest published toxic dose: 1870 mg/kg	Liver: Fatty liver degeneration	VCVGH* -,644,1990
intraperitoneal/mouse	lowest published toxic dose: 986.95 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TOXID9 -,238,2009
intraperitoneal/mouse	lowest published toxic dose: 2960.85 mg/kg	Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOXID9 -,238,2009
intraperitoneal/mouse	lowest published toxic dose: 2961 mg/kg	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOXID9 -,391,2009
intraperitoneal/rat	lowest published toxic dose: 1974 mg/kg	Liver: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOXID9 60,227,2001
intravenous/man	lowest published lethal dose: 129 mg/kg	Behavioral: General anesthetic Cardiac: Change in rate Lung, Thorax, or Respiration: Cyanosis	LANCAO 1,340,1982
oral/guinea pig	lethal dose (50 percent kill): 6 gm/kg	Behavioral: Excitement Behavioral: Antipsychotic	GTPZAB 24(3),36,1980
oral/guinea pig	lethal dose (50 percent kill): 6000 mg/kg		VCVGH* -,644,1990
oral/rat	lethal dose (50 percent kill): 5680 mg/kg	Behavioral: Excitement Behavioral: Antipsychotic	GTPZAB 24(3),36,1980
oral/rat	lethal dose (50 percent kill): 5680 mg/kg		VCVGH* -,644,1990
unreported route/woman	lowest published lethal dose: 0.4 mL/kg	Vascular: Regional or general arteriolar or venous dilation Blood: Hemorrhage	JFSCAS 45,923,2000

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 1 pph/4H/80D- intermittent	Liver: Other changes Immunological Including Allergic: Increase in cellular immune response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	TXAPA9 143,245,1997
inhalation/guinea pig	lowest published toxic concentration: 50 ppm/24H/5W- continuous	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ANESAV 42,408,1975
inhalation/guinea pig	lowest published toxic concentration: 10000 ppm/1H/7D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency Biochemical: Effect on specific coenzyme: Other coenzymes	JJATDK 9,9,1989
inhalation/mouse	lowest published toxic concentration: 300 ppm/24H/5W- continuous	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ANESAV 42,408,1975
inhalation/rat	lowest published toxic concentration: 200 mg/m³/16W- continuous	Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)	VCVGH* -,645,1990
inhalation/rat	lowest published toxic concentration: 15 ppm/4H/9W- intermittent	Liver: Liver function tests impaired Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	TOLED5 144,105,2003
inhalation/rat	lowest published toxic concentration: 50 ppm/24H/4W- continuous	Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Fatty liver degeneration Liver: Changes in liver weight	PHTOEH 62,74,1988
inhalation/rat	lowest published toxic concentration: 10000 ppm/1H/7D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency	JJATDK 9,9,1989
inhalation/rat	lowest published toxic concentration: 300 ppm/24H/5W- continuous	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ANESAV 42,408,1975
inhalation/rat	lowest published toxic concentration: 2500 ppm/8H/8W- intermittent	Brain and Coverings: Other degenerative changes Kidney, Ureter, and Bladder: Urine volume increased Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	EXNEAC 76,168,1982
inhalation/rat	lowest published toxic concentration: 5126 mg/m³/4H/17W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GTPZAB 24(3),36,1980
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/9D- intermittent	Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	DTESD7 11,407,1983

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMSUDL 7,93,1987
TOXICOLOGY REVIEW		ARPTDI 16,67,1976
TOXICOLOGY REVIEW		INTEAG 15,7,1974
TOXICOLOGY REVIEW		ARMCAH 25,411,1974
TOXICOLOGY REVIEW		CJSUAX 15,217,1972
TOXICOLOGY REVIEW		AASXAP 49,1,1971
TOXICOLOGY REVIEW		AACRAT 57,328,1978
TOXICOLOGY REVIEW		MUREAV 566,21,2004
TOXICOLOGY REVIEW		MUREAV 488,151,2001
TOXICOLOGY REVIEW		TPHSDY 23,374,2002
TOXICOLOGY REVIEW		TPHSDY 23,519,2002
TOXICOLOGY REVIEW		CRTXB2 33,105,2003
TOXICOLOGY REVIEW		TPHSDY 23,552,2002
TOXICOLOGY REVIEW		EMMUEG 43,143,2004
TOXICOLOGY REVIEW		TPHSDY 24,648,2003
TOXICOLOGY REVIEW		AINCM* 7,63,2006
TOXICOLOGY REVIEW		DIMON* 39,678,1993
TOXICOLOGY REVIEW		ENTOX* -,125,2005
TOXICOLOGY REVIEW		EJPHAZ 549,1,2006
TOXICOLOGY REVIEW		HUTOX* -,577,1996
TOXICOLOGY REVIEW		BLREV* 3,71,1989
TOXICOLOGY REVIEW		CLLID* 13,277,2009
TOXICOLOGY REVIEW		NCLNA* 16,503,1998
TOXICOLOGY REVIEW		NEUCL* 18,695,2000
TOXICOLOGY REVIEW		NEUCL* 23,397,2005
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		MUREAV 770,26,2016
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		NETEEC 52,88,2015
TOXICOLOGY REVIEW		FCTOD7 110,229,2017
TOXICOLOGY REVIEW		NETEEC 60,24,2017
TOXICOLOGY REVIEW		NETEEC 60,59,2017
TOXICOLOGY REVIEW		RTOPDW 54,84,2009
TOXICOLOGY REVIEW		RTOPDW 59,364,2011

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 ppm (4.1 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (40 mg/m³);KZW 20 ppm (160 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (410 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 ppm (40 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (8.2 mg/m³), short term exposure limit 3 ppm (25 mg/m³), NOV2011
Occupational Exposure Limit-GERMANY	MAK 5 ppm (41 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 40 mg/m³, short term exposure limit 160 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 5 ppm (40 mg/m³), NOV2011
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 ppm, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (404 mg/m³), 0,5 mg/m³ (inhal), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 40 mg/m³, short term exposure limit 100 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 20 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 5 ppm (40 mg/m³);short term exposure limit 10 ppm (80 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (40 mg/m³), KZG-week 40 ppm (320 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 40 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 ppm (82 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HALOTHANE-air	ceiling concentration 2 ppm/60M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 82943; Number of Industries 3; Total Number of Facilities 4118; Number of Occupations 15; Total Number of Employees Exposed 94682; Total Number of Female Employees Exposed 76108
National Occupational Hazard Survey 1974	Hazard Code 82943; Number of Industries 2; Total Number of Facilities 806; Number of Occupations 8; Total Number of Employees Exposed 9490

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #29

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health