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Diesel exhaust

RTECS #
HZ1755000
CAS #

See: NMAM or OSHA Methods
Updated
March 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductinhalation/mouse6200 µg/m3/16H/12W- intermittentEMMUEG 16,64,1990
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+/-enzymatic activation step)MUREAV 415,13,1998
other mutation test systemsinhalation/mouse3 gm/L/12H/4W- intermittentEMMUEG 48,682,2007
other mutation test systemsinhalation/mouse1 gm/L/12H/12W- intermittentEMMUEG 48,682,2007

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat toxic concentration: 7 mg/m3/7H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FAATDF 9,208,1987
inhalation/rat toxic concentration: 4 mg/m3/18H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
DTESD7 13,459,1986
inhalation/rat toxic concentration: 2500 µg/m3/18H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INHTE5 7,533,1995
inhalation/rat lowest published toxic concentration: 274 mg/m3/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INHTE5 12,97,2000
inhalation/rat lowest published toxic concentration: 4900 µg/m3/8H/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
DTESD7 13,349,1986
intratracheal/rat lowest published toxic dose: 36400 mg/kg/2.5Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ARDSBL 141(Suppl),A3-A937,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 350 µg/m3/4HVascular: Regional or general arteriolar constriction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,258,2008
inhalation/mouse lowest published toxic concentration: 350 µg/m3/4HVascular: Contraction (isolated tissue)TXAPA9 230,346,2008
inhalation/rat lowest published toxic concentration: 300 µg/m3/5HCardiac: Other changes

Vascular: Regional or general arteriolar constriction

Biochemical: Metabolism (intermediary): Other
TOXID9 -,150,2008
inhalation/rat lowest published toxic concentration: 300 µg/m3/5HAutonomic Nervous System: Sympathomimetic

Cardiac: Changes in coronary arteries

Vascular: BP elevation not characterized in autonomic section
TOXID9 -,258,2008

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 6300 µg/m3/20H/8W- intermittentCardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
ENVRAL 22,285,1980
inhalation/guinea pig lowest published toxic concentration: 300 µg/m3/5W- intermittentOlfaction: Other olfaction effectsAJCMED 162,352,2000
inhalation/mouse lowest published toxic concentration: 30 µg/m3/24W- intermittentBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TXAPA9 196,337,2004
inhalation/mouse lowest published toxic concentration: 3 mg/m3/12H/34W- intermittentLung, Thorax, or Respiration: Other changesTOSCF2 44,70,1998
inhalation/mouse lowest published toxic concentration: 3500 µg/m3/7H/78W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FAATDF 11,546,1988
inhalation/mouse lowest published toxic concentration: 6 mg/m3/12H/3W- intermittentEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 116,227,1997
inhalation/mouse lowest published toxic dose: 2 mg/m3/4W- intermittentCardiac: Other changes

Vascular: Structural changes in vessels
TOXID9 -,148,2008
inhalation/mouse lowest published toxic dose: 400 µg/m3/3D- intermittentBlood: Changes in spleenTOXID9 -,35,2008
inhalation/mouse lowest published toxic concentration: 200 µg/m3/6H/7W- intermittentCardiac: Other changes

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 255,184,2011
inhalation/mouse lowest published toxic concentration: 0.69 µg/m3/5H/8W- intermittentEndocrine: Adrenal cortex hypoplasiaTOLED5 209,277,2012
inhalation/rat lowest published toxic concentration: 2 mg/m3/16W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes
TOXID9 -,220,2008
inhalation/rat lowest published toxic concentration: 3500 µg/m3/7H/2Y- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FAATDF 11,546,1988
inhalation/rat lowest published toxic dose: 2 mg/m3/16W- intermittentVascular: Other changes

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,151,2008
inhalation/rat lowest published toxic concentration: 300 µg/m3/0.5Y- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 78,284,2004
inhalation/rat lowest published toxic concentration: 669.3 µg/m3/4H/3W- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,284,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 46,41,1989
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 46,41,1989
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 46,41,1989
TOXICOLOGY REVIEWENTOX* -,17,2005
TOXICOLOGY REVIEWTXAPA9 244,66,2010
TOXICOLOGY REVIEWTIVIEQ 32,92,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, carc 2, resp, JAN2011

Status in Federal Agencies

OrganizationReference
NIOSH Analytical Method, 1996: Element carbon (diesel exhaust), 5040
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
Page last reviewed: November 16, 2018