The National Institute for Occupational Safety and Health (NIOSH)

Cyclopentane

RTECS #

GY2390000

CAS #

287-92-3
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

70.15

Molecular Formula

C₅H₁₀

Synonyms

Cyclopentane (ACGIH)
Pentamethylene

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 3440 mg/m³	Lung, Thorax, or Respiration: Other changes Liver: Other changes	TOVEFN (4),34,2000
inhalation/mouse	lethal concentration (50 percent kill): 72 gm/m³	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	TOVEFN (4),33,2000
inhalation/mouse	Lowest published lethal concentration: 110000 mg/m³	Behavioral: General anesthetic	VCVGH* -,81,1990
inhalation/rat	lethal concentration (50 percent kill): 106000 mg/m³	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	TOVEFN (4),34,2000
ocular/rabbit	lowest published toxic dose: 100 pph	Eye: Conjunctiva irritation	TOVEFN (4),34,2000
oral/mouse	lethal dose (50 percent kill): 12800 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	TOVEFN (4),34,2000
oral/rat	lethal dose (50 percent kill): 11400 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	TOVEFN (4),34,2000

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 34200 mg/kg/30D- intermittent	Kidney, Ureter, and Bladder: Renal function tests depressed Blood: Other changes	TOVEFN (4),33,2000
oral/rat	lowest published toxic dose: 34200 mg/kg/30D- intermittent	Kidney, Ureter, and Bladder: Renal function tests depressed Blood: Changes in other cell count (unspecified)	TOVEFN (4),34,2000

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 600 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 539,77,2003

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 600 ppm (1720 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 600 ppm (1800 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 300 ppm (850 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 600 ppm (1720 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 300 ppm (850 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 600 ppm (1720 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 600 ppm (1720 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 300 ppm (850 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 600 ppm (1721 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 600 ppm (1720 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1720 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOPENTANE-air	10H time-weighted average 600 ppm	NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974	Hazard Code 82935; Number of Industries 77; Total Number of Facilities 8027; Number of Occupations 52; Total Number of Employees Exposed 74753

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health

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