Cyclohexylamine
RTECS #
GX0700000
CAS #
Updated
December 2018
Molecular Weight
99.20
Molecular Formula
C6H13N
Synonyms
Aminocyclohexane
Aminohexahydrobenzene
Aniline, hexahydro-
Benzenamine, hexahydro-
CHA
Cyclohexanamine
Cyclohexylamine (ACGIH)
Hexahydroaniline
Hexahydrobenzenamine
Aminohexahydrobenzene
Aniline, hexahydro-
Benzenamine, hexahydro-
CHA
Cyclohexanamine
Cyclohexylamine (ACGIH)
Hexahydroaniline
Hexahydrobenzenamine
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 50 µg/24H | severe | 85JCAE -,454,1986 |
eye /rabbit | 100 µL/5M | severe | NTIS** OTS0540890 |
skin /human | 125 mg/48H | severe | AMIHBC 5,311,1952 |
skin /rabbit | 2 mg/24H | severe | 85JCAE -,454,1986 |
skin /rabbit | 500 µL | severe | NTIS** OTS0540890 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | leukocyte/human | 10 µmol/L/5H | MUREAV 39,1,1976 |
Cytogenetic Analysis | intraperitoneal/rat | 5 mg/kg/5D-continuous | SCIEAS 165,1139,1969 |
Cytogenetic Analysis | fibroblast/hamster | 10 mg/L | MUREAV 39,1,1976 |
Cytogenetic Analysis | unreported route/domestic animal | 50 mg/kg | MUREAV 26,407,1974 |
Cytogenetic Analysis | kidney/mammal (species unspecified) | 50 mg/L/8H-continuous | FCTXAV 8,617,1970 |
DNA inhibition | HeLa cell/human | 100 µg/L | INHEAO 9,188,1971 |
Dominant Lethal Test | intraperitoneal/mouse | 500 mg/kg/5D- intermittent | MUREAV 14,126,1972 |
host-mediated assay | leukocyte/hamster | 450 mg/kg/3D-continuous | MUREAV 31,5,1975 |
morphological transform | embryo/hamster | 60 mg/L | AETODY 1,241,1980 |
specific locus test | intraperitoneal/mouse | 200 mg/kg | PCBRD2 109,339,1982 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | 300 mg/kg (1D male) | Reproductive: Effects on fertility: Other measures of fertility | FCTXAV 10,29,1972 |
intraperitoneal/rat | 100 mg/kg (1D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FCTXAV 10,29,1972 |
intraperitoneal/mouse | 61 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 4,141,1971 |
intraperitoneal/mouse | 77 mg/kg (11D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TJADAB 4,141,1971 |
intraperitoneal/mouse | 200 mg/kg (10D pregnant) | Reproductive: Effects on fertility: Other measures of fertility | PCBRD2 109,339,1982 |
oral/mouse | 600 mg/kg (6-11D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death | SEIJBO 11,51,1971 |
oral/mouse | 120 mg/kg (6-11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | SEIJBO 11,51,1971 |
oral/Dog | 14 gm/kg (8W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FCTXAV 19,291,1981 |
oral/Dog | 15750 mg/kg (9W male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FCTXAV 19,291,1981 |
oral/rat | 5600 mg/kg (4W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FCTXAV 19,291,1981 |
parenteral/mouse | 250 mg/kg (5D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | AMESES 1,33,1970 |
unreported route/rat | 5 mg/kg (1D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | AMESES 1,25,1970 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, skin | Inhibitor Concentration Low: 0.08 mL/well/3M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,616,2014 |
inhalation/guinea pig | Lowest published lethal concentration: 1200 ppm/7H | Lung, Thorax, or Respiration: Other changes | IMSUAI 19,317,1950 |
inhalation/mouse | lethal concentration (50 percent kill): 1070 mg/m3 | Behavioral: Excitement Behavioral: Muscle contraction or spasticity | GTPZAB 7(11),51,1963 |
inhalation/rabbit | Lowest published lethal concentration: 150 ppm/7H | IMSUAI 19,317,1950 | |
inhalation/rat | lethal concentration (50 percent kill): 7500 mg/m3 | Behavioral: Excitement Behavioral: Muscle contraction or spasticity | GTPZAB 7(11),51,1963 |
intraperitoneal/mammal (species unspecified) | lethal dose (50 percent kill): 200 mg/kg | Brain and Coverings: Other degenerative changes Vascular: Shock Liver: Other changes | AMIHBC 5,311,1952 |
intraperitoneal/mouse | lethal dose (50 percent kill): 129 mg/kg | PCJOAU 22,469,1988 | |
intraperitoneal/rat | lethal dose (50 percent kill): 300 mg/kg | Eye: Mydriasis (pupilliary dilation) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | NYKZAU 65(1),53S,1969 |
intravenous/Dog | lethal dose (50 percent kill): 200 mg/kg | Behavioral: Convulsions or effect on seizure threshold | NYKZAU 65(1),53S,1969 |
intravenous/mouse | lethal dose (50 percent kill): 200 mg/kg | IPSTB3 3,93,1976 | |
oral/mouse | lethal dose (50 percent kill): 224 mg/kg | 85GMAT -,41,1982 | |
oral/rat | lethal dose (50 percent kill): 11 mg/kg | Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Pulmonary emboli Gastrointestinal: Other changes | NTIS** OTS0534836 |
parenteral/rabbit | lowest published lethal dose: 500 mg/kg | Behavioral: Convulsions or effect on seizure threshold | IECHAD 29,1247,1937 |
skin/rabbit | lethal dose (50 percent kill): 320 µL/kg | AIHAAP 30,470,1969 | |
subcutaneous/mouse | lethal dose (50 percent kill): 1150 mg/kg | VOONAW 4,659,1958 | |
unreported route/mouse | lethal dose (50 percent kill): 770 mg/kg | TXAPA9 14,654,1969 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 700 mg/m3/2H/9W- intermittent | Cardiac: Changes in heart weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GTPZAB 7(11),51,1963 |
inhalation/rat | lowest published toxic concentration: 100 mg/m3/4H/22W- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in cell count (unspecified) Nutritional and Gross Metabolic: Other changes | GTPZAB 7(11),51,1963 |
oral/rat | lowest published toxic dose: 1200 mg/kg/3D- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | EXMPA6 52,155,1990 |
oral/rat | lowest published toxic dose: 2800 mg/kg/1W- continuous | Related to Chronic Data: Changes in testicular weight | EXMPA6 52,155,1990 |
oral/rat | lowest published toxic dose: 8400 mg/kg/3W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | EXMPA6 52,155,1990 |
oral/rat | lowest published toxic dose: 35700 mg/kg/1Y- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VOONAW 4,659,1958 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMSUDL 7,178,1987 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal NO EVIDENCE | IMEMDT 22,55,1980 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMSUDL 22,55,1980 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,178,1987 |
TOXICOLOGY REVIEW | MUREAV 39,1,1976 | |
TOXICOLOGY REVIEW | NBREV* 17,313,1993 | |
TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXYLAMINE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code 84526; Number of Industries 83; Total Number of Facilities 4729; Number of Occupations 47; Total Number of Employees Exposed 64346; Total Number of Female Employees Exposed 2914 | |
National Occupational Hazard Survey 1974 | Hazard Code 84526; Number of Industries 63; Total Number of Facilities 3468; Number of Occupations 25; Total Number of Employees Exposed 9450 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health