4-Cyclohexene-1,2-dicarboximide, N-((1,1,2,2-tetrachloroethyl)thio)-

RTECS #

GW4900000

CAS #

2425-06-1
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

349.06

Molecular Formula

C₁₀H₉Cl₄NO₂S

Synonyms

1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-((1,1,2,2-tetrachloroethyl)thio)- (9CI)
3a,4,7,7a-Tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide
Alfloc 7020
Alfloc 7046
Arborseal
Captafol
Captafol (ACGIH)
CS5623
Difolatan
Difolatan 4F
Difolatan 80W
Difolatan BOW
Difosan
Folcid
Foltaf
Haipen 50
Merpafol
N-((1,1,2,2-Tetrachloroethyl)sulfenyl)-cis-4-cyclohexene-1,2-dicarboximide
N-(1,1,2,2-Tetrachloraethylthio)-cyclohex-4-en-1,4-diacarboximid (German)
N-(1,1,2,2-Tetrachloraethylthio)-tetrahydrophthalamid (German)
N-(1,1,2,2-Tetrachloroethylthio)-4-cyclohexene-1,2-dicarboximide
N-1,1,2,2-Tetrachloroethylmercapto-4-cyclohexene-1,2-carboximide
Nalco 7046
Ortho 5865
Proxel EF
Sanspor
Santar SM
Terrazol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /human	0.05%/48H		CODEDG 17,212,1987

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	embryo/human	3400 µg/L	SNSHBT (20),574,1980
Cytogenetic Analysis	lung/hamster	10 µmol/L	MUREAV 78,177,1980
DNA Damage	kidney/rat	1 µmol/L/20H	TXCYAC 204,187,2004
DNA Damage	oral/rat	1250 mg/kg	TXCYAC 204,187,2004
DNA Damage	kidney/human	0.5 µmol/L/20H	TXCYAC 204,187,2004
DNA inhibition	other cell types/rat	80 mg/L	ARTODN 45,101,1980
DNA inhibition	lymphocyte/human	5 mg/L	ARTODN 45,101,1980
DNA repair	/Bacillus subtilis	100 ng/disc	MUREAV 40,19,1976
Dominant Lethal Test	intraperitoneal/rat	25 mg/kg/5D	FCTXAV 10,353,1972
gene conversion and mitotic recombination	/Aspergillus nidulans	20 µg/plate	MUREAV 46,395,1977
micronucleus test	embryo/human	3400 µg/L	SNSHBT (20),574,1980
micronucleus test	lung/hamster	3400 µg/L	SNSHBT (20),574,1980
micronucleus test	kidney/human	1 µmol/L/48H	TXCYAC 204,187,2004
micronucleus test	kidney/rat	0.5 µmol/L/48H	TXCYAC 204,187,2004
micronucleus test	oral/rat	1250 mg/kg	TXCYAC 204,187,2004
morphological transform	oral/rat	7560 mg/kg/6W	CRNGDP 9,387,1988
mutation in microorganisms	/Aspergillus nidulans	20 µg/plate (-enzymatic activation step)	MUREAV 46,395,1977
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate (+enzymatic activation step)	EMCAE8 5,11,1985
mutation in microorganisms	/Escherichia coli	50 µg/plate (-enzymatic activation step)	MUREAV 40,19,1976
mutation in microorganisms	/Escherichia coli	50 µg/plate (+enzymatic activation step)	MUREAV 116,185,1983
other mutation test systems	/Escherichia coli	100 µg/L	MUREAV 390,245,1997
sister chromatid exchange	embryo/human	3400 µg/L	SNSHBT (20),574,1980
sister chromatid exchange	lung/hamster	2 µmol/L	MUREAV 78,177,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	500 mg/kg (5D male)	Reproductive: Effects on embryo or fetus: Fetal death	FCTXAV 10,363,1972
oral/rabbit	975 mg/kg (6-18D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TXAPA9 13,420,1968
oral/hamster	200 mg/kg (8D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 16,24,1970
oral/hamster	400 mg/kg (7D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	TXAPA9 16,24,1970
oral/rat	11 gm/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 13,420,1968
oral/rat	250 mg/kg (5D male)	Reproductive: Effects on embryo or fetus: Fetal death	FCTXAV 10,363,1972

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 60480 mg/kg/96W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors	GANNA2 75,853,1984
oral/mouse	toxic dose: 15120 mg/kg/96W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Cardiac: Tumors Gastrointestinal: Tumors	JTSCDR 7,278,1982
oral/rat	lowest published toxic dose: 65520 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	JJCREP 81,1222,1990

Acute Toxicity Data and References

Route/Organism	Dose	Reference
intraperitoneal/mouse	lowest published lethal dose: 3 mg/kg	FCTXAV 13,55,1975
oral/rat	lethal dose (50 percent kill): 2500 mg/kg	WRPCA2 9,119,1970
skin/rabbit	lethal dose (50 percent kill): 15400 mg/kg	ENTOX* -,407,2005
unreported route/rat	lethal dose (50 percent kill): >6 gm/kg	RREVAH 36,240,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 45360 mg/kg/12W- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Changes in spleen weight	JTEHD6 38,69,1993
oral/rat	lowest published toxic dose: 39894.4 mg/kg/104W- continuous	Liver: Tumors	HBPTO* 1,814,2001
oral/rat	lowest published toxic dose: 39894.4 mg/kg/104W- continuous	Kidney, Ureter, and Bladder: Kidney tumors	HBPTO* 1,814,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Available Data	IMEMDT 53,353,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2A	IMEMDT 53,353,1991
TOXICOLOGY REVIEW		MUREAV 32,3,1975
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		ENTOX* -,407,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		HUTOX* -,561,1996
TOXICOLOGY REVIEW		FCTOD7 46,813,2008
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUREAV 823,45,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,93,1998
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.1 mg/m³, Skin, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	ceiling concentration 0.1 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 mg/m³, carc, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.1 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, inhal, skin, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPTAFOL-air	10H Carcinogen time-weighted average 0.1 mg/m³ (Sk)	NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974	Hazard Code M2985; Number of Industries 1; Total Number of Facilities 59; Number of Occupations 1; Total Number of Employees Exposed 117

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health