Cyclohexanol

RTECS #

GV7875000

CAS #

108-93-0
See: NMAM or OSHA Methods

Updated

July 2016

Molecular Weight

100.18

Molecular Formula

C₆H₁₂O

Synonyms

Adronal
Anol
Cicloesanolo (Italian)
Cyclohexanol (ACGIH:OSHA)
Cyclohexyl alcohol
Cykloheksanol (Polish)
Hexahydrophenol
Hexalin
Hydralin
Hydrophenol
Hydroxycyclohexane
Naxol
Phenol, hexahydro-

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	100 ppm		JIHTAB 25,282,1943
eye /rabbit	100 µL/24H	moderate	NTIS** OTS0572833
eye /rabbit	100 µL/24H	mild	NTIS** OTS0572832
eye /rabbit	10 µL	moderate	JTPAE7 29,187,2001
skin /rabbit	500 µL/24H	moderate	NTIS** OTS0572833
skin /rabbit	500 µL/24H	mild	NTIS** OTS0572832

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	leukocyte/human	100 µmol/L	DBTEAD 19,215,1971
DNA Damage	lymphocyte/mammal (species unspecified)	150 mmol/L	PNASA6 48,686,1962
specific locus test	other cell types/mouse	2500 mg/L	MUTAEX 15,45,2000

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
subcutaneous/rat	315 mg/kg (21D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	IJEBA6 17,1305,1979
subcutaneous/gerbil	315 mg/kg (21D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	IJEBA6 17,1305,1979

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
unreported route/rat	lowest published toxic dose: 400 mg/kg/4D- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Tumorigenic: Facilitates action of known carcinogens	MOCAE8 46,524,2007

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, skin	Inhibitor Concentration Low: 60 µL/well/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1476,2013
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1425,2011
inhalation/human	lowest published toxic concentration: 400 mg/m³/3M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,129,1984
inhalation/human	lowest published toxic concentration: 75 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
inhalation/mammal (species unspecified)	lowest published toxic concentration: 1870 mg/m³/40M	Brain and Coverings: Other degenerative changes	VCVGK* -,129,1984
inhalation/mouse	lowest published toxic concentration: 7 mg/m³	Behavioral: General anesthetic	VCVGK* -,129,1984
inhalation/rat	lowest published toxic concentration: 7 mg/m³	Behavioral: General anesthetic	VCVGK* -,129,1984
inhalation/rat	Lethal concentration: >6500 mg/m³/1H		NTIS** OTS0572832
inhalation/rat	lethal concentration (50 percent kill): >3630 mg/m³		HPV188 -,-,2001
intramuscular/mouse	lethal dose (50 percent kill): 1 gm/kg		JSICAZ 21,342,1962
intraperitoneal/mouse	lethal dose (50 percent kill): 1352 mg/kg		ARZNAD 19,1254,1969
intravenous/mouse	lethal dose (50 percent kill): 272 mg/kg		AIPTAK 135,330,1962
oral/rabbit	lowest published lethal dose: 2200 mg/kg	Behavioral: General anesthetic	JIHTAB 25,199,1943
oral/rabbit	lowest published lethal dose: 2600 mg/kg		VCVGK* -,129,1984
oral/rat	lethal dose (50 percent kill): 1550 mg/kg	Lung, Thorax, or Respiration: Other changes Gastrointestinal: Gastritis Blood: Hemorrhage	HPV188 -,-,2001
oral/rat	lethal dose (50 percent kill): 2060 mg/kg		HPV188 -,-,2001
oral/rat	lethal dose (50 percent kill): 1400 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0538617
parenteral/frog	lowest published lethal dose: 1914 mg/kg	Cardiac: Other changes	JPETAB 24,405,1925
skin/rabbit	lowest published lethal dose: 794 mg/kg	Lung, Thorax, or Respiration: Other changes Gastrointestinal: Gastritis Liver: Other changes	HPV188 -,-,2001
skin/rabbit	lowest published lethal dose: 794 mg/kg	Behavioral: Somnolence (general depressed activity) Liver: Change in gall bladder structure or function Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0538617

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	lowest published toxic concentration: 1229 ppm/6H/5W- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 25,323,1943
inhalation/rabbit	lowest published toxic concentration: 997 ppm/6H/11W- intermittent	Behavioral: General anesthetic Eye: Conjunctiva irritation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 25,323,1943
inhalation/rabbit	lowest published toxic concentration: 4930 mg/m³/6H/5W- intermittent	Behavioral: General anesthetic Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,129,1994
inhalation/rabbit	lowest published toxic concentration: 580 mg/m³/6H/5W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,129,1994
inhalation/rat	lowest published toxic concentration: 70 mg/m³/4H/122D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,129,1994
inhalation/rat	lowest published toxic concentration: 30 mg/m³/4H/134D- intermittent	Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,129,1994
intraperitoneal/rat	lowest published toxic dose: 4 gm/kg/10D- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	TOLED5 45,271,1989
oral/rabbit	lowest published toxic dose: 1000 mg/kg/40D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	HPV188 -,-,2001
oral/rat	lowest published toxic dose: 3185 mg/kg/7D- intermittent	Liver: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other	HPV188 -,-,2001
oral/rat	lowest published toxic dose: 3185 mg/kg/7D- continuous	Liver: Other changes Liver: Changes in liver weight	APTOA6 51,217,1982
skin/rabbit	lowest published toxic dose: 50 mL/kg/1H/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,129,1994
subcutaneous/gerbil	lowest published toxic dose: 315 mg/kg/21D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	HPV188 -,-,2001
subcutaneous/rat	lowest published toxic dose: 555 mg/kg/21D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	HPV188 -,-,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 50 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		NTAPM* -,629,1995
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 50 ppm (200 mg/m³)	DTLVS* 3,65,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (206 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (200 mg/m³);KZW 200 ppm (800 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (209 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (200 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (210 mg/m³), short term exposure limit 75 ppm (310 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 50 ppm (200 mg/m³), VLE 75 ppm (300 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 200 mg/m³, short term exposure limit 800 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (200 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 25 ppm (102 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 50 ppm (200 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 50 ppm (200 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 50 ppm (206 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (100 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 50 ppm (205 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 20 mg/m³, short term exposure limit 60 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 25 ppm, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 50 ppm (200 mg/m³);short term exposure limit 75 ppm (300 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 50 ppm (200 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 50 ppm (200 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 50 ppm (208 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (200 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (200 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (200 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (200 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANOL-air	10H time-weighted average 50 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 21560; Number of Industries 52; Total Number of Facilities 10121; Number of Occupations 66; Total Number of Employees Exposed 112365; Total Number of Female Employees Exposed 41412
National Occupational Hazard Survey 1974	Hazard Code 21560; Number of Industries 56; Total Number of Facilities 6542; Number of Occupations 63; Total Number of Employees Exposed 65435

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9206
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health