Cyanamide
RTECS #
GS5950000
CAS #
Updated
September 2013
Molecular Weight
42.05
Molecular Formula
CH2N2
Synonyms
Alzogur
Amidocyanogen
Carbamonitrile
Carbimide
Carbodiimide
Cyanamide (ACGIH)
Cyanoamine
Cyanogen nitride
Cyanogenamide
Hydrogen cyanamide
N-Cyanoamine
TsAKS
USAF EK-1995
Amidocyanogen
Carbamonitrile
Carbimide
Carbodiimide
Cyanamide (ACGIH)
Cyanoamine
Cyanogen nitride
Cyanogenamide
Hydrogen cyanamide
N-Cyanoamine
TsAKS
USAF EK-1995
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 2450 mg/kg (70D male/2W pre-2W pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Other measures of fertility | PHTOEH 61,20,1987 |
| oral/rat | 1750 mg/kg (70D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | PHTOEH 61,20,1987 |
| oral/rat | 2600 mg/kg (70D male/2W pre-3W pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects | PHTOEH 61,20,1987 |
| oral/rat | 208 mg/kg (70D male/2W pre-3W pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | PHTOEH 61,20,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lowest published lethal concentration: 86 mg/m3/4H | 85GMAT -,40,1982 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 200 mg/kg | NTIS** AD277-689 | |
| intraperitoneal/rat | lowest published lethal dose: 200 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Coma Gastrointestinal: Changes in structure or function of salivary glands | PSEBAA 54,254,1943 |
| intraperitoneal/rat | lowest published toxic dose: 60 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | EKFAE9 59,38,1996 |
| intraperitoneal/rat | lowest published toxic dose: 25 gm/kg | Taste: Change in function | PSCHDL 167,130,2003 |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | PSCHDL 189,459,2007 |
| intravenous/rat | lethal dose (50 percent kill): 56 mg/kg | ENTOX* -,695,2005 | |
| oral/cat | lethal dose (50 percent kill): 100 mg/kg | 85GMAT -,40,1982 | |
| oral/mouse | lethal dose (50 percent kill): 388 mg/kg | 85GMAT -,40,1982 | |
| oral/rabbit | lethal dose (50 percent kill): 150 mg/kg | 85GMAT -,40,1982 | |
| oral/rat | lethal dose (50 percent kill): 125 mg/kg | ENTOX* -,695,2005 | |
| skin/rabbit | lethal dose (50 percent kill): 590 mg/kg | ENTOX* -,695,2005 | |
| skin/rat | lethal dose (50 percent kill): 84 mg/kg | ENTOX* -,695,2005 | |
| unreported route/rat | lethal dose (50 percent kill): 280 mg/kg | 34ZIAG -,190,1969 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| unreported route/human | lowest published toxic dose: 312 mg/kg/182D- intermittent | Blood: Aplastic anemia | EJCPAS 61,467,2005 |
| unreported route/woman | lowest published toxic dose: 61 mg/kg/61D- intermittent | Blood: Aplastic anemia | SANGR* 35,412,1990 |
| unreported route/woman | lowest published toxic dose: 20 mg/kg/20D- intermittent | Blood: Aplastic anemia | EJHAEC 48,179,1992 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 mg/m3 | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ENTOX* -,695,2005 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Active registration | RBREV* -,373,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (11 mg/m3) (skin) | DTLVS* 3,130,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.58 ppm (1 mg/m3), inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.58 ppm (1 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.58 ppm (1 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 1 mg/m3 (0.58 ppm), skin, FEB2006 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 2 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.2 ppm (0.35 mg/m3), inhal, vapor, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 2 mg/m3 (resp), short term exposure limit 8 mg/m3 (resp), SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.58 ppm (1 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 2 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 2 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 2 mg/m3;short term exposure limit 4 mg/m3, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.58 ppm (1 mg/m3), KZG-week 1.16 ppm (2 mg/m3), inhal, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.58 ppm (1 mg/m3), skin, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANAMIDE-air | 10H time-weighted average 2 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 20930; Number of Industries 2; Total Number of Facilities 19; Number of Occupations 2; Total Number of Employees Exposed 2564; Total Number of Female Employees Exposed 272 | |
| National Occupational Hazard Survey 1974 | Hazard Code 20930; Number of Industries 2; Total Number of Facilities 76; Number of Occupations 2; Total Number of Employees Exposed 962 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health