m-Cresol, 4,4'-thiobis(6-tert-butyl-

RTECS #

GP3150000

CAS #

96-69-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

358.58

Molecular Formula

C₂₂H₃₀O₂S

Synonyms

1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)
4,4'-Thiobis
4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
4,4'-Thiobis(2-tert-butyl-5-methylphenol)
4,4'-Thiobis(3-methyl-6-tert-butylphenol)
4,4'-Thiobis(6-tert-butyl-3-methylphenol)
4,4'-Thiobis(6-tert-butyl-m-cresol)
4,4'-Thiobis(6-tert-butyl-m-cresol) (ACGIH,OSHA)
Antage Crystal
Antioxidant AO
Antioxidant TMB 6
AO 4
Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
Disperse MB-61
Nocrac 300
Nonflex BPS
Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl- (9CI)
Santonox
Santonox BM
Santonox R
Santowhite crystals
Santox
Sumilizer WX
Sumilizer WX-R
Thioalkofen BM 4
Thioalkofen BMCH
Thioalkofen MBCH
Thioalkophene BM-4
USAF B-15
Yoshinox S
Yoshinox SR

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	5508.3 mg/kg (61D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ARTODN 80,225,2006
oral/mouse	25803 mg/kg (61D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ARTODN 80,225,2006
oral/rat	11742.5 mg/kg (61D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ARTODN 80,225,2006
oral/rabbit	26 mg/kg (6-18D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	HPV260 -,-,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 50 mg/kg		NTIS** AD277-689
oral/rabbit	lethal dose (50 percent kill): 3200 mg/kg		IPSTB3 3,93,1976
oral/rat	lethal dose (50 percent kill): 4150 mg/kg	Behavioral: Food intake (animal) Gastrointestinal: Gastritis Liver: Other changes	HPV260 -,-,2001
oral/rat	lethal dose (50 percent kill): 2345 mg/kg		IPSTB3 3,93,1976
skin/rabbit	lethal dose (50 percent kill): >5010 mg/kg	Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	HPV260 -,-,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 1400 mg/kg/14D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	FAATDF 10,691,1988
oral/mouse	lowest published toxic dose: 5915 mg/kg/13W- continuous	Liver: Changes in liver weight Endocrine: Changes in spleen weight	NTPTR* NTP-TR-435,1994
oral/mouse	lowest published toxic dose: 5508.3 mg/kg/61D- intermittent	Related to Chronic Data: Changes in testicular weight	ARTODN 80,225,2006
oral/mouse	lowest published toxic dose: 10980 mg/kg/61D- intermittent	Endocrine: Androgenic	ARTODN 80,225,2006
oral/mouse	lowest published toxic dose: 25803 mg/kg/61D- intermittent	Liver: Changes in liver weight Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	ARTODN 80,225,2006
oral/mouse	lowest published toxic dose: 18239 mg/kg/61D- intermittent	Nutritional and Gross Metabolic: Body temperature decrease Related to Chronic Data: Changes in uterine weight	ARTODN 80,225,2006
oral/mouse	lowest published toxic dose: 2730 mg/kg/2Y- intermittent	Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	HPV260 -,-,2001
oral/mouse	lowest published toxic dose: 10920 mg/kg/2Y- intermittent	Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count	HPV260 -,-,2001
oral/mouse	lowest published toxic dose: 10920 mg/kg/13W- intermittent	Blood: Changes in erythrocyte (RBC) count	HPV260 -,-,2001
oral/mouse	lowest published toxic dose: 27300 mg/kg/13W- intermittent	Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	HPV260 -,-,2001
oral/mouse	lowest published toxic dose: 4500 mg/kg/15D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV260 -,-,2001
oral/mouse	lowest published toxic dose: 9000 mg/kg/15D- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 36500 mg/kg/2Y- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in erythrocyte (RBC) count	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 3750 mg/kg/15D- intermittent	Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 7500 mg/kg/15D- intermittent	Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 4550 mg/kg/13W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Other changes	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 5475 mg/kg/15D- continuous	Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in leukocyte (WBC) count	NTPTR* NTP-TR-435,1994
oral/rat	lowest published toxic dose: 15015 mg/kg/13W- continuous	Liver: Changes in liver weight Blood: Normocytic anemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	NTPTR* NTP-TR-435,1994
oral/rat	lowest published toxic dose: 11742.5 mg/kg/61D- intermittent	Blood: Changes in spleen Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	ARTODN 80,225,2006
subcutaneous/mouse	lowest published toxic dose: 150 mg/kg/3D- intermittent	Related to Chronic Data: Changes in uterine weight	ARTODN 80,225,2006
subcutaneous/mouse	lowest published toxic dose: 240 mg/kg/4D- intermittent	Related to Chronic Data: Changes in uterine weight	ARTODN 80,225,2006

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 mg/m³ (inhal)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		TOPADD 33,517,2005

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 10 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air	time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84755; Number of Industries 10; Total Number of Facilities 1286; Number of Occupations 11; Total Number of Employees Exposed 12349; Total Number of Female Employees Exposed 2177
National Occupational Hazard Survey 1974	Hazard Code 84755; Number of Industries 51; Total Number of Facilities 4402; Number of Occupations 47; Total Number of Employees Exposed 36695

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health