p-Cresol, 2,6-di-tert-butyl-

RTECS #

GO7875000

CAS #

128-37-0; 58500-82-6
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

220.39

Molecular Formula

C₁₅H₂₄O

Synonyms

2,6-Bis(1,1-dimethylethyl)-4-methylphenol
2,6-Di-terc.butyl-p-kresol (Czech)
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-4-methylphenol
2,6-Di-tert-butyl-p-cresol
2,6-Di-tert-butyl-p-cresol (ACGIH)
2,6-Di-tert-butyl-p-methylphenol
3,5-Di-tert-butyl-4-hydroxytoluene
4-Hydroxy-3,5-di-tert-butyltoluene
4-Methyl-2,6-di-terc. butylfenol (Czech)
4-Methyl-2,6-di-tert-butylphenol
Advastab 401
Agidol
Agidol 1
Alkofen BP
Antioxidant 29
Antioxidant 30
Antioxidant 4
Antioxidant 4K
Antioxidant DBPC
Antioxidant KB
Antrancine 8
AO 29
AO 4K
BHT
BHT (food grade)
BUKS
Butylated hydroxytoluene
Butylhydroxytoluene
Butylohydroksytoluenu (Polish)
CAO 1
CAO 3
Catalin cao-3
Chemanox 11
Dalpac
DBMP
DBPC
DBPC (technical grade)
Deenax
Dibunol
Dibutylated hydroxytoluene
Impruvol
Ionol
Ionol (antioxidant)
Ionol 1
Ionol CP
Ionole
Kerabit
Methyldi-tert-butylphenol
NCI-C03598
Nocrac 200
Nonox TBC
P 21
Parabar 441
Paranox 441
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl- (9CI)
Stavox
Sumilizer BHT
Sustane BHT
Swanox BHT
Tenamene 3
Tenox BHT
Topanol
Topanol O
Topanol OC
Toxolan P
Vanlube PC
Vanlube PCX
Vianol
Vulkanox KB

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg/24H	moderate	85JCAE -,229,1986
skin /human	500 mg/48H	mild	AMIHBC 5,311,1952
skin /rabbit	500 mg/48H	moderate	AMIHBC 5,311,1952

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	100 µg/L	MUREAV 345,73,1995
DNA Damage	oral/mouse	100 mg/kg	MUREAV 519,103,2002
DNA Damage	oral/rat	1400 mg/kg/2D	HPV260 -,-,2001
DNA Damage	oral/rat	1400 mg/kg	FCTOD7 25,603,1987
DNA inhibition	HeLa cell/human	500 µmol/L	CRNGDP 13,2389,1992
DNA inhibition	lymphocyte/human	20 µmol/L	BBRCA9 80,963,1978
DNA inhibition	intraperitoneal/mouse	250 mg/kg	CBINA8 19,279,1977
Dominant Lethal Test	oral/mouse	12 gm/kg/10W-continuous	NTIS** PB278-026
Dominant Lethal Test	oral/rat	5460 mg/kg/10W-continuous	ENMUDM 8,357,1986
mutation in mammalian somatic cells	lymphocyte/mouse	6 mg/L	EMMUEG 11,91,1988
mutation in microorganisms	lymphocyte/mouse	6 mg/L (+enzymatic activation step)	EMMUEG 11,91,1988
other mutation test systems	oral/mouse	500 mg/kg	MUREAV 343,157,1995
specific locus test	other cell types/mouse	45 µmol/L	MUREAV 608,29,2006
sperm morphology	intraperitoneal/mouse	350 mg/kg/5D- intermittent	CMMUAO 5,257,1978
Unscheduled DNA Synthesis	oral/rat	16800 mg/kg/4W-continuous	TXAPA9 99,37,1989
Unscheduled DNA Synthesis	liver/rat	100 pmol/L	CRNGDP 5,1547,1984
Unscheduled DNA Synthesis	intraperitoneal/rat	1200 mg/kg/3D-continuous	DANKAS 287,371,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	6 gm/kg (13W male/13W pre-3W after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FCTOD7 24,1,1986
oral/rat	18 gm/kg (2W male/2W pre-3W after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral	FCTXAV 19,153,1981
oral/rat	9 gm/kg (2W male/2W pre-3W after birth)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	FCTXAV 19,153,1981
oral/rat	35 gm/kg (10W male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	ENMUDM 8,357,1986
oral/mouse	43800 mg/kg (52D prior to copulation/1-21D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FCTXAV 3,371,1965
oral/mouse	12600 mg/kg (1-21D pregnant)	Reproductive: Effects on newborn: Behavioral	FEPRA7 31,596,1972
oral/mouse	1200 mg/kg (9D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TRENAF 28(2),45,1977
oral/rat	28000 mg/kg (multigeneration)	Reproductive: Other effects on female Reproductive: Effects on newborn: Biochemical and metabolic	HPV260 -,-,2001
oral/rat	3300 mg/kg (7-17D pregnant)	Reproductive: Effects on newborn: Physical	HPV260 -,-,2001
oral/mouse	1200 mg/kg (9D pregnant)	Reproductive: Other effects on female	HPV260 -,-,2001

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 435 mg/kg/69W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors	FCTXAV 12,367,1974
oral/mouse	toxic dose: 1423 mg/kg/43W- continuous	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors	TXCYAC 38,151,1986
oral/mouse	lowest published toxic dose: 1200 mg/kg/3W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumor types after systemic administration not seen spontaneously	CALEDQ 145,101,1999
oral/rat	lowest published toxic dose: 134 gm/kg/32W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Tumorigenic: Cells (cultured) transformed	CRNGDP 4,895,1983
oral/rat	toxic dose: 247 gm/kg	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	FCTOD7 24,1121,1986
oral/rat	toxic dose: 963 gm/kg	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors	FCTOD7 24,1071,1986
oral/rat	toxic dose: 247 gm/kg/3Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Liver: Tumors	FCTOD7 24,1,1986
oral/rat	toxic dose: 247 gm/kg/3Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Reproductive: Tumorigenic effects: Ovarian tumors	FCTOD7 24,1,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 10 mg/L	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	JOETD7 146,456,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 2.5 mg/L/16H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	JOETD7 146,456,2013
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): 0.15 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 1,85,1987
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 4.04 mmol/L/24H	In Vitro Toxicity Studies: Cell counting	TIVIEQ 18,79,2004
intraperitoneal/mouse	lowest published toxic dose: 150 mg/kg	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other proteins	CRTOEC 21,1631,2008
intraperitoneal/mouse	lethal dose (50 percent kill): 138 mg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	IJTOFN 21,19,2002
intraperitoneal/mouse	lethal dose (50 percent kill): 138 mg/kg		ENTOX* -,365,2005
intraperitoneal/mouse	lethal dose (50 percent kill): 138 mg/kg	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage	TXAPA9 61,475,1981
intraperitoneal/mouse	lowest published toxic dose: 100 mg/kg	Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Changes in lung weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,212,1994
intraperitoneal/rat	lethal dose (50 percent kill): 8 gm/kg		IJTOFN 21,19,2002
intraperitoneal/rat	lowest published toxic dose: 10 mg/kg	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport	FATOAO 55,34,1992
intraperitoneal/rat	lowest published toxic dose: 1 mg/kg	Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)	TXAPA9 223,164,2007
intravenous/mouse	lethal dose (50 percent kill): 180 mg/kg	Behavioral: Sleep	JMCMAR 23,1350,1980
oral/cat	lowest published lethal dose: 940 mg/kg	Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression	AMIHAB 11,93,1955
oral/cat	lowest published lethal dose: 940 mg/kg		VCVGK* -,212,1994
oral/guinea pig	lethal dose (50 percent kill): 10700 mg/kg	Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression	AMIHAB 11,93,1955
oral/guinea pig	lethal dose (50 percent kill): 10700 mg/kg		ENTOX* -,365,2005
oral/mouse	lethal dose (50 percent kill): 1040 mg/kg		ENTOX* -,365,2005
oral/mouse	lethal dose (50 percent kill): 650 mg/kg	Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes	IJTOFN 21,19,2002
oral/mouse	lowest published toxic dose: 50 mg/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	EKFAE9 62,56,1999
oral/mouse	lethal dose (50 percent kill): 650 mg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion	SRTCAC 36(1-4),10,1989
oral/rabbit	lowest published lethal dose: 2100 mg/kg	Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression	AMIHAB 11,93,1955
oral/rabbit	lethal dose (50 percent kill): 2100 mg/kg		VCVGK* -,212,1994
oral/rabbit	lowest published lethal dose: 2000 mg/kg		VCVGK* -,212,1994
oral/rat	lowest published toxic dose: 25 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	EKFAE9 62,56,1999
oral/rat	lethal dose (50 percent kill): 890 mg/kg		ENTOX* -,365,2005
oral/woman	lowest published toxic dose: 80 mg/kg	Behavioral: Coma Gastrointestinal: Gastritis Gastrointestinal: Nausea or vomiting	NEJMAG 314,648,1986
rectal/mouse	lowest published toxic dose: 50 mg/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	EKFAE9 62,56,1999
rectal/rat	lowest published toxic dose: 25 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	EKFAE9 62,56,1999
skin/rat	lethal dose (50 percent kill): >2000 mg/kg		HPV260 -,-,2001
subcutaneous/mouse	lethal dose (50 percent kill): 650 mg/kg		ENTOX* -,365,2005

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/guinea pig	lowest published toxic dose: 570 mg/kg/3D- intermittent	Blood: Change in clotting factors	VCVGK* -,212,1994
intraperitoneal/hamster	lowest published toxic dose: 1140 mg/kg/3D- intermittent	Brain and Coverings: Changes in circulation Behavioral: Tremor	VCVGK* -,212,1994
intraperitoneal/mouse	lowest published toxic dose: 1750 mg/kg/1W- intermittent	Gastrointestinal: Tumors Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors	VCVGK* -,213,1994
intraperitoneal/mouse	lowest published toxic dose: 600 mg/kg/4W- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other proteins	CRTOEC 21,1631,2008
intraperitoneal/mouse	lowest published toxic dose: 750 mg/kg/3W- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 169,1,2001
intraperitoneal/mouse	lowest published toxic dose: 750 mg/kg/3W- intermittent	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 169,1,2001
intraperitoneal/mouse	lowest published toxic dose: 735 mg/kg/4W- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	JNCIEQ 97,1778,2005
intraperitoneal/rabbit	lowest published toxic dose: 480 mg/kg/4D- intermittent	Cardiac: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	FATOAO 55,19,1992
oral/hamster	lowest published toxic dose: 1596 mg/kg/14D- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	FCTOD7 34,595,1996
oral/monkey	lowest published toxic dose: 14 gm/kg/4W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FCTXAV 10,769,1972
oral/mouse	lowest published toxic dose: 13500 mg/kg/18D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	FCTXAV 3,417,1965
oral/mouse	lowest published toxic dose: 48600 mg/kg/30D- continuous	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	FCTOD7 30,89,1992
oral/mouse	lowest published toxic dose: 10.08 mg/kg/1W- continuous	Brain and Coverings: Changes in circulation Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,212,1994
oral/mouse	lowest published toxic dose: 2000 mg/kg/4D- intermittent	Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,212,1994
oral/rat	lowest published toxic dose: 6.3 mg/kg/1W- continuous	Brain and Coverings: Changes in circulation Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,212,1994
oral/rat	lowest published toxic dose: 547.5 mg/kg/2Y- continuous	Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,213,1994
oral/rat	lowest published toxic dose: 1200 mg/kg/3D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	FATOAO 50,81,1987
oral/rat	lowest published toxic dose: 840 mg/kg/14D- intermittent	Cardiac: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	EKFAE9 56,47,1993
oral/rat	lowest published toxic dose: 5185 mg/kg/4W- continuous	Liver: Other changes Liver: Changes in liver weight	TOLED5 87,103,1996
oral/rat	lowest published toxic dose: 109 gm/kg/2Y- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count	FCTXAV 19,147,1981
oral/rat	lowest published toxic dose: 27 gm/kg/90D- continuous	Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Endocrine: Changes in thyroid weight	TOLED5 10,239,1982
oral/rat	lowest published toxic dose: 37800 mg/kg/6W- continuous	Liver: Changes in liver weight Endocrine: Changes in adrenal weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AJEBAK 39,353,1961
oral/rat	lowest published toxic dose: 5600 mg/kg/16W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition	FCTXAV 3,433,1965
oral/rat	lowest published toxic dose: 275 mg/kg/26W- continuous	Liver: Changes in liver weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AJEBAK 37,533,1959
oral/rat	lowest published toxic dose: 112 gm/kg/80W- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 7,289,1977
oral/rat	lowest published toxic dose: 5040 mg/kg/7D- continuous	Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	APTOA6 49,14,1981
oral/rat	lowest published toxic dose: 350 mg/kg/7D- intermittent	Gastrointestinal: Other changes Liver: Other changes	FATOAO 47,87,1984
oral/rat	lowest published toxic dose: 350 mg/kg/7D- intermittent	Gastrointestinal: Other changes	FATOAO 47,87,1984
oral/rat	lowest published toxic dose: 500 mg/kg/5D- intermittent	Gastrointestinal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	EKFAE9 61,21,1998
oral/rat	lowest published toxic dose: 39.7 mg/kg/3D- intermittent	Blood: Change in clotting factors	EKFAE9 62,38,1999
oral/rat	lowest published toxic dose: 6300 mg/kg/6W- continuous	Liver: Tumors Tumorigenic: Protects against induction of experimental tumors Tumorigenic: Active as anti-cancer agent	CALEDQ 143,173,1999
oral/rat	lowest published toxic dose: 2.625 mg/kg/1W- continuous	Liver: Other changes Blood: Change in clotting factors Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	VCVGK* -,212,1994
oral/rat	lowest published toxic dose: 2000 mg/kg/4D- intermittent	Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,212,1994
oral/rat	lowest published toxic dose: 4200 mg/kg/14D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	BIJOAK 300,117,1994
oral/rat	lowest published toxic dose: 778.4 mg/kg/28D- continuous	Liver: Other changes	FCTOD7 46,2616,2008
oral/rat	lowest published toxic dose: 2458.4 mg/kg/28D- continuous	Liver: Other changes Liver: Changes in liver weight	FCTOD7 46,2616,2008
oral/rat	lowest published toxic dose: 4673.2 mg/kg/28D- continuous	Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	FCTOD7 46,2616,2008
oral/rat	lowest published toxic dose: 8999.2 mg/kg/28D- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	FCTOD7 46,2616,2008
oral/rat	lowest published toxic dose: 32446.4 mg/kg/28D- continuous	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 46,2616,2008
oral/rat	lowest published toxic dose: 239400 mg/kg/76W- intermittent	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV260 -,-,2001
oral/rat	lowest published toxic dose: 119700 mg/kg/76W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV260 -,-,2001
skin/mouse	lowest published toxic dose: 5 gm/kg/4W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOLED5 34,99,1986

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
TOXICOLOGY REVIEW		FEPRA7 35,89,1976
TOXICOLOGY REVIEW		IJTOFN 21,19,2002
TOXICOLOGY REVIEW		ENTOX* -,365,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 659,15,2008
TOXICOLOGY REVIEW		HUTOX* -,259,1996
TOXICOLOGY REVIEW		HUTOX* -,577,1996
TOXICOLOGY REVIEW		MUREAV 705,184,2010
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		RTOPDW 55,200,2009
TOXICOLOGY REVIEW		RTOPDW 56,67,2010
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 mg/m³, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 mg/m³, C carcinogen, 2011
Occupational Exposure Limit-GERMANY	MAK 10 mg/m³, inhal, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 10 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air	10H time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 83383; Number of Industries 210; Total Number of Facilities 27242; Number of Occupations 154; Total Number of Employees Exposed 591238; Total Number of Female Employees Exposed 163774
National Occupational Hazard Survey 1974	Hazard Code 83383; Number of Industries 32; Total Number of Facilities 1526; Number of Occupations 39; Total Number of Employees Exposed 28860

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat	NCITR* NCI-TR-150,1979

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health