Carbamic acid, methyl-, 1-naphthyl ester

RTECS #

FC5950000

CAS #

63-25-2; 11095-11-7; 52001-89-5
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

201.24

Molecular Formula

C₁₂H₁₁NO₂

Synonyms

1-Naftylester kyseliny methylkarbaminove (Czech)
1-Naphthalenol, methylcarbamate (9CI)
1-Naphthalenyl methylcarbamate
1-Naphthol N-methylcarbamate
1-Naphthyl methylcarbamate
1-Naphthyl N-methylcarbamate
1-Naphthyl-N-methyl-karbamat (German)
alpha-Naftyl-N-methylkarbamat (Czech)
alpha-Naphthalenyl methylcarbamate
alpha-Naphthyl N-methylcarbamate
Arilat
Arilate
Arylam
Atoxan
Bug master
Carbaril
Carbaryl
Carbaryl (ACGIH:OSHA)
Carbatox
Carbatox-60
Carbatox-75
Carbavur
Carbomate
Carylderm
Cekubaryl
Compound 7744
Crunch
Denapon
Dicarbam
Dyna-carbyl
ENT 23,969
Experimental Insecticide 7744
Germain's
Hexavin
Karbaryl (Polish)
Karbatox
Karbatox 75
Karbatox zawiesinowy
Karbosep
Latka 7744 (Czech)
Menaphtam
Methylcarbamic acid, 1-naphthyl ester
Monsur
Mugan
Murvin
NAC (insecticide)
NMC 50
N-Methyl-1-naftyl-carbamaat (Dutch)
N-Methyl-1-naphthyl carbamate
N-Methyl-1-naphthyl-carbamat (German)
N-Methyl-alpha-naphthylcarbamate
N-Methyl-alpha-naphthylurethan
N-Methylcarbamate de 1-naphtyle (French)
N-Metil-1-naftil-carbammato (Italian)
Oltitox
OMS-29
Panam
Pomex
Prosevor 85
Ravyon
Savit
Seffein
Sevimol
Sevin
Sevin (OSHA)
Sevin 4
Tercyl
Toxan
Tricarnam
UC 7744
Union carbide 7,744
Vetox
Vioxan

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,955,1986
skin /rabbit	12 mg/24H	severe	JAFCAU 9,30,1961

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	parenteral/grasshopper	100 pph	CUSCAM 43,187,1974
Cytogenetic Analysis	embryo/human	40 mg/L	ZDVKAP 20(4),14,1977
Cytogenetic Analysis	fibroblast/hamster	30 mg/L/48H	MUREAV 48,337,1977
Cytogenetic Analysis	lung/hamster	100 µmol/L	MUREAV 119,319,1983
DNA inhibition	other cell types/rat	1 mg/L	ARTODN 45,101,1980
DNA inhibition	Ascites tumor/mouse	100 µmol/L	BECTA6 14,441,1975
DNA inhibition	lymphocyte/human	50 mg/L	ARTODN 45,101,1980
DNA inhibition	lung/human	1 mmol/L	NNGADV 8,353,1983
host-mediated assay	Ascites tumor/mouse	60 mg/kg/5D- intermittent	BECTA6 14,441,1975
micronucleus test	multiple/non-mammalian species	5 ppm/8D-continuous	MUREAV 125,275,1984
mutation in mammalian somatic cells	lung/hamster	10 µmol/L	CBINA8 19,369,1977
mutation in microorganisms	/Saccharomyes cerevisiae	100 ppm (-enzymatic activation step)	RSTUDV 6,161,1976
mutation in microorganisms	/Salmonella typhimurium	250 µg/plate (+enzymatic activation step)	RPZHAW 30,81,1979
mutation in microorganisms	/Salmonella typhimurium	100 µmol/L (-enzymatic activation step)	ARTODN 39,159,1977
mutation in microorganisms	/Other microorganisms	5 mg/L (-enzymatic activation step)	JASIAB 104,571,1985
other mutation test systems	lung/human	1 mmol/L	NNGADV 8,353,1983
other mutation test systems	fibroblast/human	100 mg/kg	GTPZAB 17(3),32,1973
other mutation test systems	Ascites tumor/mouse	400 µmol/L	BECTA6 14,441,1975
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	1 pph/24H	SOGEBZ 8,798,1972
sex chromosome loss and nondisjunction	lung/hamster	50 µmol/L	MUREAV 119,319,1983
sperm morphology	intraperitoneal/mouse	1 mmol/L	BSRSA6 45,46,1976
sperm morphology	oral/mouse	1 mmol/L	BSRSA6 45,46,1976
Unscheduled DNA Synthesis	fibroblast/human	1 µmol/L	MUREAV 42,161,1977

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1370 mg/kg (39W prior to copulation)	Reproductive: Maternal effects: Menstrual cycle changes or disorders	VPITAR 27(6),49,1968
oral/rat	5500 mg/kg (multigenerations)	Reproductive: Effects on fertility: Other measures of fertility	TXAPA9 17,273,1970
oral/rat	27500 µg/kg (multigenerations)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 21,390,1972
oral/rat	220 mg/kg (5-15D pregnant)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TXAPA9 21,390,1972
oral/rat	1370 mg/kg (39W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VPITAR 27(6),49,1968
oral/rat	5475 mg/kg (52W prior to copulation)	Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	VPITAR 27(6),49,1968
oral/rat	3250 mg/kg (13W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VHTODE 37,421,1995
oral/mouse	11660 mg/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 51,81,1979
oral/mouse	100 mg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system	FCTOD7 29,629,1991
oral/mouse	200 mg/kg (8D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	FCTOD7 29,629,1991
oral/mouse	150 mg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	FCTOD7 29,629,1991
oral/Dog	375 mg/kg (3-62D pregnant)	Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Hepatobiliary system	TXAPA9 13,392,1968
oral/Dog	750 mg/kg (3-62D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TXAPA9 13,392,1968
oral/Dog	197 mg/kg (1-63D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Stillbirth	32OAAP -,253,1973
oral/Dog	394 mg/kg (1-63D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system	32OAAP -,253,1973
oral/rabbit	1950 mg/kg (6-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 51,81,1979
oral/rabbit	2600 mg/kg (6-18D pregnant)	Reproductive: Specific developmental abnormalities: Body wall	TXAPA9 51,81,1979
oral/pig	912 mg/kg (1-16W pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	32OAAP -,253,1973
oral/guinea pig	300 mg/kg (12-16D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 15,152,1969
oral/hamster	250 mg/kg (8D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TXAPA9 15,152,1969
oral/gerbil	12500 mg/kg (multigenerations)	Reproductive: Effects on fertility: Other measures of fertility	TXAPA9 17,273,1970
oral/gerbil	20300 mg/kg (multigenerations)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TXAPA9 19,202,1971
oral/gerbil	20300 mg/kg (multigenerations)	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	TXAPA9 19,202,1971
oral/gerbil	40600 mg/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 19,202,1971
oral/rat	375 mg/kg (14-22D preg/7D after birth)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TOXID9 36,344,1997
oral/rat	555 mg/kg (7-22D preg/21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	FCTOD7 99,135,2017
subcutaneous/mouse	900 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** PB223-160
subcutaneous/mouse	900 mg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** PB223-160
subcutaneous/mouse	418 mg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)	NTIS** PB223-160
subcutaneous/mouse	4176 mg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB223-160

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
implant/rat	lowest published toxic dose: 80 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	VPITAR 29,71,1970
oral/rat	lowest published toxic dose: 5640 mg/kg/94W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors	VPITAR 29,71,1970

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 500 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 28,1507,2014
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	TIVIEQ 28,1507,2014
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 50 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TIVIEQ 28,1507,2014
In Vitro/Human, melanoma	Inhibitor Concentration (50 percent kill): 339 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 38,67,2017
In Vitro/Human, melanoma	Inhibitor Concentration (50 percent kill): 251 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 38,67,2017
In Vitro/Human, melanoma	Inhibitor Concentration (50 percent kill): 218 µmol/L/72H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 38,67,2017
In Vitro/Human, melanoma	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Cell counting	TIVIEQ 38,67,2017
In Vitro/Human, melanoma	Inhibitor Concentration Low: 100 µmol/L/48H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	TIVIEQ 38,67,2017
In Vitro/Human, melanoma	Inhibitor Concentration Low: 100 µmol/L/6H	In Vitro Toxicity Studies: Other assays In Vitro Toxicity Studies: Phototoxicity in vitro	TIVIEQ 38,67,2017
In Vitro/Rat, endocrine tumor	Inhibitor Concentration (50 percent kill): >10 µmol/L/20M	In Vitro Toxicity Studies: Other assays	NRTXDN 43,110,2014
In Vitro/Rat, neurons	Inhibitor Concentration Low: 40 µmol/L/1H	In Vitro Toxicity Studies: Other assays	NRTXDN 44,204,2014
In Vitro/Rat, neurons	Inhibitor Concentration (50 percent kill): 5.03 µmol/L/10M	In Vitro Toxicity Studies: Other assays	NRTXDN 40,75,2014
In Vitro/Rat, neurons	Inhibitor Concentration Low: 25 mg/L/2H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TIVIEQ 3,111,1989
In Vitro/Rat, neurons	Inhibitor Concentration (50 percent kill): 17 mmol/L/2H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TIVIEQ 3,111,1989
inhalation/cat	lowest published toxic concentration: 40 mg/m³	Behavioral: Change in motor activity (specific assay)	HBPTO* 2,1099,2001
inhalation/guinea pig	Lethal concentration: >390 mg/m³/4H		UCDS** 11/21/1973
inhalation/rat	lethal concentration (50 percent kill): 5 mg/m³		HBPTO* 2,1094,2001
inhalation/rat	lowest published toxic concentration: 300 mg/m³/15M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 -,175,2009
inhalation/rat	lowest published toxic concentration: 30 mg/m³/3H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 -,175,2009
intramuscular/monkey	lowest published toxic dose: 3 mg/kg	Peripheral Nerve and Sensation: Recording from peripheral motor nerve Peripheral Nerve and Sensation: Structural change in nerve or sheath	HBPTO* 2,1100,2001
intramuscular/rat	lowest published toxic dose: 3 mg/kg	Behavioral: Alteration of operant conditioning	HBPTO* 2,1095,2001
intraperitoneal/hamster	lethal dose (50 percent kill): 640 mg/kg		ARTODN 58,152,1986
intraperitoneal/mouse	lethal dose (50 percent kill): 25 mg/kg		TXAPA9 6,402,1964
intraperitoneal/rabbit	lethal dose (50 percent kill): 223 mg/kg		JAFCAU 9,30,1961
intraperitoneal/rat	lethal dose (50 percent kill): 64 mg/kg		PSEBAA 114,509,1963
intraperitoneal/rat	lowest published toxic dose: 7.3 mg/kg	Behavioral: Change in psychophysiological tests	HBPTO* 2,1099,2001
intravenous/rat	lethal dose (50 percent kill): 18 mg/kg		JAFCAU 9,30,1961
oral/cat	lethal dose (50 percent kill): 150 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands	GISAAA 32(4),29,1967
oral/cat	lethal dose (50 percent kill): 125 mg/kg		HBPTO* 2,1094,2001
oral/Dog	lethal dose (50 percent kill): 250 mg/kg		HBPTO* 2,1094,2001
oral/gerbil	lethal dose (50 percent kill): 491 mg/kg		PCBPBS 21,199,1984
oral/guinea pig	lethal dose (50 percent kill): 250 mg/kg		PCBPBS 21,199,1984
oral/hamster	lowest published lethal dose: 250 mg/kg		TXAPA9 15,152,1969
oral/human	lowest published toxic dose: 2.8 mg/kg	Gastrointestinal: Nausea or vomiting Gastrointestinal: Other changes	HBPTO* 2,1096,2001
oral/mammal (species unspecified)	lethal dose (50 percent kill): 510 mg/kg		HPBIA9 21,53,1975
oral/man	lowest published toxic dose: 500 mg/kg	Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Muscle weakness	NEURAI 37,1229,1987
oral/monkey	lethal dose (50 percent kill): 1000 mg/kg		HBPTO* 2,1094,2001
oral/mouse	lethal dose (50 percent kill): 108 mg/kg		HBPTO* 2,1094,2001
oral/mouse	lowest published toxic dose: 5 mg/kg/1H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 288,429,2015
oral/mouse	lowest published toxic dose: 0.5 mg/kg/24H	Biochemical: Metabolism (intermediary): Other proteins	TXAPA9 288,429,2015
oral/mouse	lowest published toxic dose: 0.5 mg/kg/20M	Behavioral: Change in psychophysiological tests	TXAPA9 288,429,2015
oral/pig	lethal dose (50 percent kill): 1500 mg/kg		HBPTO* 2,1094,2001
oral/pig	lowest published toxic dose: 20 mg/kg	Behavioral: Change in psychophysiological tests	HBPTO* 2,1098,2001
oral/quail	lethal dose (50 percent kill): 829 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands	OYYAA2 51,137,1996
oral/rabbit	lethal dose (50 percent kill): 710 mg/kg		HBPTO* 2,1094,2001
oral/rat	lethal dose (50 percent kill): 233 mg/kg		HBPTO* 2,1094,2001
oral/rat	lowest published toxic dose: 0.56 mg/kg	Behavioral: Change in psychophysiological tests	HBPTO* 2,1100,2001
oral/rat	lethal dose (50 percent kill): 230 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 11,546,1967
oral/rat	lowest published toxic dose: 10 mg/kg	Cardiac: EKG changes not diagnostic of above Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 282,184,2015
oral/rat	lowest published toxic dose: 50 mg/kg	Endocrine: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXAPA9 282,161,2015
oral/rat	lowest published toxic dose: 3 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXCYAC 331,1,2015
oral/rat	lowest published toxic dose: 75 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Metabolism (intermediary): Other	NRTXDN 30,377,2009
oral/rat	lowest published toxic dose: 75 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 -,337,2009
oral/rat	lowest published toxic dose: 50 mg/kg	Brain and Coverings: Changes in surface EEG Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 -,441,2009
oral/rat	lowest published toxic dose: 50 mg/kg	Behavioral: Tremor Behavioral: Alteration of classical conditioning Gastrointestinal: Changes in structure or function of salivary glands	TOXID9 44,224,2005
oral/rat	lowest published toxic dose: 15 mg/kg	Behavioral: Change in motor activity (specific assay) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 66,321,2002
oral/rat	lowest published toxic dose: 10 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 217,1,2006
oral/rat	lowest published toxic dose: 50 mg/kg	Behavioral: Tremor Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 217,1,2006
oral/rat	lowest published lethal dose: 75 mg/kg	Behavioral: Tremor Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 217,1,2006
oral/rat	lowest published toxic dose: 3 mg/kg	Behavioral: Change in motor activity (specific assay)	TOXID9 90,302,2006
oral/rat	lowest published toxic dose: 3 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NRTXDN 29,87,2008
oral/rat	lowest published toxic dose: 75 mg/kg	Brain and Coverings: Recordings from specific areas of CNS	NRTXDN 29,87,2008
oral/rat	lowest published toxic dose: 30 mg/kg	Nutritional and Gross Metabolic: Body temperature decrease	NRTXDN 29,87,2008
oral/rat	lowest published toxic dose: 30 mg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Somnolence (general depressed activity) Behavioral: Tremor	TOXID9 12,478,2008
oral/wild bird	lethal dose (50 percent kill): 56 mg/kg		TXAPA9 21,315,1972
oral/woman	lowest published lethal dose: 5 gm/kg	Autonomic Nervous System: Parasympatholytic Cardiac: Change in rate Nutritional and Gross Metabolic: Other changes	HETOEA 11,373,1992
skin/rabbit	lethal dose (50 percent kill): 2 gm/kg		85DPAN -,-,1971/1976
skin/rat	lethal dose (50 percent kill): 4 gm/kg		85DPAN -,-,1971/1976
subcutaneous/chicken	lowest published lethal dose: 2 gm/kg		JAFCAU 9,30,1961
subcutaneous/mouse	lethal dose (50 percent kill): 860 mg/kg		AHRTAN 29,251,1978
subcutaneous/rabbit	Lethal dose: >2 gm/kg		JAFCAU 9,30,1961
subcutaneous/rat	lethal dose (50 percent kill): 1400 mg/kg		34ZIAG -,528,1969
Tank with water/Lugworm	lethal concentration (50 percent kill): 7.2 mg/L/48H		AQUTO* 10,235,1987
Tank with water/Shrimp	lethal concentration (50 percent kill): 12 µg/L/96H		EESADV 73,360,2010
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 310 mg/kg		GISAAA 53(7),72,1988
unreported route/mouse	lethal dose (50 percent kill): 370 mg/kg		GISAAA 49(10),23,1984
unreported route/rat	lethal dose (50 percent kill): 500 mg/kg		30ZDA9 -,188,1971
unreported route/rat	lowest published toxic dose: 80 mg/kg	Behavioral: Change in motor activity (specific assay)	TOXID9 72,128,2003

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 63 mg/kg/4W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 32(4),29,1967
inhalation/rat	lowest published toxic concentration: 214 µg/m³/24H/13W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 53(7),72,1988
inhalation/rat	lowest published toxic concentration: 12 mg/m³/6H/16W- intermittent	Behavioral: Change in psychophysiological tests	HBPTO* 2,1100,2001
inhalation/rat	lowest published toxic concentration: 23 mg/m³/4H/17W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning	GISAAA 43(11),33,1978
oral/mouse	lowest published toxic dose: 0.5 mg/kg/120D- intermittent	Biochemical: Metabolism (intermediary): Other proteins	TXAPA9 288,429,2015
oral/mouse	lowest published toxic dose: 11.4 gm/kg/16D- continuous	Behavioral: Food intake (animal)	FCTOD7 41,99,2003
oral/mouse	lowest published toxic dose: 15.2 gm/kg/20D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 41,99,2003
oral/mouse	lowest published toxic dose: 32.22 gm/kg/180D- continuous	Liver: Changes in liver weight Endocrine: Changes in thymus weight	FCTOD7 41,99,2003
oral/mouse	lowest published toxic dose: 3222 mg/kg/180D- continuous	Kidney, Ureter, and Bladder: Other changes	FCTOD7 41,99,2003
oral/mouse	lowest published toxic dose: 16.8 gm/kg/7D- intermittent	Behavioral: Fluid intake Behavioral: Change in motor activity (specific assay) Behavioral: Aggression	BECTA6 71,37,2003
oral/pig	lowest published toxic dose: 8157 mg/kg/72D- intermittent	Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Musculoskeletal: Other changes	TXAPA9 14,409,1969
oral/pig	lowest published toxic dose: 9.6 gm/kg/46D- intermittent	Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Ataxia Behavioral: Muscle contraction or spasticity	HBPTO* 2,1098,2001
oral/quail	lowest published toxic dose: 13230 mg/kg/14W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	BECTA6 17,360,1977
oral/rabbit	lowest published toxic dose: 7.59 mg/kg/33D- continuous	Immunological Including Allergic: Decrease in humoral immune response	TXAPA9 32,587,1975
oral/rabbit	lowest published toxic dose: 131.1 mg/kg/57D- continuous	Endocrine: Other changes	TXAPA9 32,587,1975
oral/rat	lowest published toxic dose: 4725 mg/kg/21D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 47,86,2009
oral/rat	lowest published toxic dose: 4725 mg/kg/21D- intermittent	Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 47,86,2008
oral/rat	lowest published toxic dose: 720 mg/kg/10D- intermittent	Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	GISAAA 49(5),80,1984
oral/rat	lowest published toxic dose: 300 mg/kg/50D- continuous	Brain and Coverings: Recordings from specific areas of CNS Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins	TXAPA9 27,465,1974
oral/rat	lowest published toxic dose: 30 mg/kg/30D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	BECTA6 23,438,1979
oral/rat	lowest published toxic dose: 1050 mg/kg/21D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	AECTCV 14,459,1985
oral/rat	lowest published toxic dose: 10800 mg/kg/96D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAFCAU 9,30,1961
oral/rat	lowest published toxic dose: 25480 mg/kg/1Y- intermittent	Endocrine: Evidence of thyroid hypofunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	FCTXAV 6,461,1968
oral/rat	lowest published toxic dose: 1109 mg/kg/22W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	GISAAA 35(7),97,1970
oral/rat	lowest published toxic dose: 500 mg/kg/50D- continuous	Behavioral: Change in psychophysiological tests	HBPTO* 2,1100,2001
unreported route/quail	lowest published toxic dose: 50 µg/kg/5D- intermittent	Immunological Including Allergic: Decreased immune response	HBPTO* 1,775,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 12,37,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 12,37,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		85ALAU -,106,1977
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		ENTOX* -,588,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		FEREAC 73,29456,2008
TOXICOLOGY REVIEW		REPTED 26,1,2008
TOXICOLOGY REVIEW		MUREAV 681,3,2009
TOXICOLOGY REVIEW		FEREAC 73,64229,2008
TOXICOLOGY REVIEW		FEREAC 73,52607,2008
TOXICOLOGY REVIEW		REPTED 26,13,2008
TOXICOLOGY REVIEW		HETOEA 26,321,2007
TOXICOLOGY REVIEW		NTAPM* -,711,1995
TOXICOLOGY REVIEW		TOLED5 190,107,2009
TOXICOLOGY REVIEW		REPTED 31,392,2011
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		MUREAV 760,1,2014
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		NRTXDN 33,1473,2012
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXCYAC 307,136,2013
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 83,300,2015
TOXICOLOGY REVIEW		NETEEC 52,68,2015
TOXICOLOGY REVIEW		FCTOD7 105,456,2017
TOXICOLOGY REVIEW		RTOPDW 54,294,2009

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,94,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 mg/m³	DTLVS* 3,37,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 1 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 5 mg/m³, skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 1 mg/m³, MAC(short term exposure limit) 8 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBARYL-air	10H time-weighted average 5 mg/m³;min expos during pregnancy	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 47800; Number of Industries 5; Total Number of Facilities 2381; Number of Occupations 4; Total Number of Employees Exposed 16544; Total Number of Female Employees Exposed 3228
National Occupational Hazard Survey 1974	Hazard Code 47800; Number of Industries 5; Total Number of Facilities 678; Number of Occupations 16; Total Number of Employees Exposed 14120

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Carbaryl, 5006
On EPA IRIS database
OSHA ANALYTICAL METHOD #63

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health