Carbamic acid, methyl-, o-isopropoxyphenyl ester
RTECS #
FC3150000
CAS #
Updated
December 2017
Molecular Weight
209.27
Molecular Formula
C11H15NO3
Synonyms
2(1-Methylethoxy)phenol methyl carbamate
2-(1-Methylethoxy)phenol methylcarbamate
2-Isopropoxyphenyl N-methylcarbamate
2-Isopropoxyphenyl-N-methylcarbamat (German)
2-Isopropoxyphenyl-N-methylcarbamate
Arprocarb
BAY 39007
BAY 5122
Bayer 39007
Bayer B 5122
Baygon
Baygon (OSHA)
Blattanex
Blattosep
Carbamic acid, methyl-, 2-(1-methylethoxy)phenyl ester
Chemagro 9010
ENT 25,671
Invisi-Gard
n-2-(1-Methylethoxy)phenyl methyl-carbamate
o-IMPC
o-Isopropoxyphenyl N-methylcarbamate
OMS-33
PHC (carbamate)
PHC 7
Phenol, o-isopropoxy-, methylcarbamate
Propoksuru (Polish)
Propoxur
Propoxur (ACGIH)
Propoxylor
Sendran
Suncide
Tendex
Tugon fliegenkugel
Unden (pesticide)
2-(1-Methylethoxy)phenol methylcarbamate
2-Isopropoxyphenyl N-methylcarbamate
2-Isopropoxyphenyl-N-methylcarbamat (German)
2-Isopropoxyphenyl-N-methylcarbamate
Arprocarb
BAY 39007
BAY 5122
Bayer 39007
Bayer B 5122
Baygon
Baygon (OSHA)
Blattanex
Blattosep
Carbamic acid, methyl-, 2-(1-methylethoxy)phenyl ester
Chemagro 9010
ENT 25,671
Invisi-Gard
n-2-(1-Methylethoxy)phenyl methyl-carbamate
o-IMPC
o-Isopropoxyphenyl N-methylcarbamate
OMS-33
PHC (carbamate)
PHC 7
Phenol, o-isopropoxy-, methylcarbamate
Propoksuru (Polish)
Propoxur
Propoxur (ACGIH)
Propoxylor
Sendran
Suncide
Tendex
Tugon fliegenkugel
Unden (pesticide)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 0.05 mg/L/1H | FCTOD7 45,928,2007 |
| Cytogenetic Analysis | ovary/hamster | 0.04 mg/L/2H | FCTOD7 45,928,2007 |
| Cytogenetic Analysis | intraperitoneal/hamster | 250 mg/kg | ARTODN 58,152,1986 |
| DNA Damage | other cell types/other fish | 75 mg/L/24H | TIVIEQ 28,340,2014 |
| DNA Damage | oral/rabbit | 534.36 mg/kg/1Y- intermittent | TXCYAC 307,109,2013 |
| Dominant Lethal Test | oral/mouse | 125 mg/kg/5D-continuous | GISAAA 44(7),75,1979 |
| micronucleus test | lymphocyte/human | 50 mg/L | MUREAV 232,45,1990 |
| mutation in microorganisms | /Salmonella typhimurium | 250 ng/plate (+enzymatic activation step) | RPZHAW 30,81,1979 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 5 ppm (-enzymatic activation step) | RSTUDV 6,161,1976 |
| sister chromatid exchange | lymphocyte/human | 50 mg/L | MUREAV 232,45,1990 |
| sister chromatid exchange | lung/hamster | 200 mg/L | CRNGDP 19,623,1998 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 1600 mg/kg (6-22D preg/15D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects | BECTA6 20,624,1978 |
| oral/rat | 650 mg/kg (7-19D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JPFCD2 20,373,1985 |
| oral/mouse | 600 mg/kg (7-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | JPFCD2 20,373,1985 |
| oral/mouse | 50 mg/kg (7-16D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | JPFCD2 20,373,1985 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/nzx | Inhibitor Concentration Low: 75 mg/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,340,2014 |
| In Vitro/nzx | Inhibitor Concentration (50 percent kill): 89.96 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,340,2014 |
| In Vitro/nzx | Inhibitor Concentration (50 percent kill): 103.4 mg/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 28,340,2014 |
| In Vitro/nzx | Inhibitor Concentration (50 percent kill): 86.59 mg/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 28,340,2014 |
| In Vitro/nzx | Inhibitor Concentration Low: 100 mg/L/24H | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | TIVIEQ 28,340,2014 |
| In Vitro/nzx | Inhibitor Concentration Low: 150 mg/L/24H | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay In Vitro Toxicity Studies: Apoptosis in vitro | TIVIEQ 28,340,2014 |
| inhalation/rat | lethal concentration (50 percent kill): 1440 mg/m3 | HBPTO* 2,1094,2001 | |
| inhalation/rat | lethal concentration (50 percent kill): 1440 mg/m3/1H | 85GYAV -,70,1971 | |
| intramuscular/rat | lethal dose (50 percent kill): 53 mg/kg | BJIMAG 22,317,1965 | |
| intraperitoneal/hamster | lethal dose (50 percent kill): 500 mg/kg | ARTODN 58,152,1986 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 12 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JAFCAU 16,561,1968 |
| intraperitoneal/rat | lethal dose (50 percent kill): 30 mg/kg | Behavioral: General anesthetic Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | BWHOA6 44,241,1971 |
| intravenous/rabbit | lethal dose (50 percent kill): 5 mg/kg | Lung, Thorax, or Respiration: Other changes | TXAPA9 165,27,2000 |
| intravenous/rat | lethal dose (50 percent kill): 11 mg/kg | BJIMAG 22,317,1965 | |
| oral/chicken | lethal dose (50 percent kill): 46500 µg/kg | Behavioral: Convulsions or effect on seizure threshold | TXAPA9 7,606,1965 |
| oral/Dog | lowest published toxic dose: 5 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,697,2001 |
| oral/Dog | lowest published toxic dose: 2 mg/kg | Eye: Other eye effects Gastrointestinal: Other changes Skin and Appendages: Other: Sweating | HBPTO* 1,697,2001 |
| oral/duck | lethal dose (50 percent kill): 9580 µg/kg | TXAPA9 22,556,1972 | |
| oral/guinea pig | lethal dose (50 percent kill): 40 mg/kg | HBPTO* 2,1094,2001 | |
| oral/human | lowest published toxic dose: 0.36 mg/kg | Olfaction: Other olfaction effects Gastrointestinal: Hypermotility, diarrhea | HBPTO* 1,697,2001 |
| oral/human | lowest published toxic dose: 0.36 mg/kg | Eye: Other eye effects Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1097,2001 |
| oral/human | lowest published toxic dose: 1.5 mg/kg | Behavioral: Headache Cardiac: Pulse rate increased without fall in BP Gastrointestinal: Nausea or vomiting | HBPTO* 2,1097,2001 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 90 mg/kg | HPBIA9 21,53,1975 | |
| oral/mouse | lethal dose (50 percent kill): 37 mg/kg | HBPTO* 2,1094,2001 | |
| oral/mouse | lethal dose (50 percent kill): 23500 µg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation | TOIZAG 17,60,1970 |
| oral/pigeon | lethal dose (50 percent kill): 7500 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 28 mg/kg | TXAPA9 20,57,1971 | |
| oral/rabbit | lowest published lethal dose: 30 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Somnolence (general depressed activity) | HBPTO* 1,697,2001 |
| oral/rat | lowest published toxic dose: 25 mg/kg | Behavioral: Muscle contraction or spasticity | HBPTO* 1,697,2001 |
| oral/rat | lethal dose (50 percent kill): 41 mg/kg | YKYUA6 37,1621,1986 | |
| oral/rat | lowest published toxic dose: 30 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 29,87,2008 |
| oral/rat | lowest published toxic dose: 0.3 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 44,397,2005 |
| oral/wild bird | lethal dose (50 percent kill): 3800 µg/kg | TXAPA9 21,315,1972 | |
| oral/woman | lowest published lethal dose: 24 mg/kg | Behavioral: Coma Cardiac: Pulse rate decreased with fall in BP Blood: Change in clotting factors | PGMJAO 63,311,1987 |
| oral/woman | lowest published lethal dose: 0.6 mL/kg | Cardiac: Arrythmias (indlucing changes in conduction) Blood: Other hemolysis with or without anemia Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | JEMME* 34,295,2008 |
| skin/mammal (species unspecified) | lethal dose (50 percent kill): 800 mg/kg | PSTDAN 15(10),37,1981 | |
| skin/mouse | lethal dose (50 percent kill): >1360 mg/kg | YKYUA6 31,711,1980 | |
| skin/rabbit | lowest published toxic dose: 2000 mg/kg | HBPTO* 1,697,2001 | |
| skin/rabbit | lethal dose (50 percent kill): 500 mg/kg | HBPTO* 2,1094,2001 | |
| skin/rabbit | lowest published toxic dose: 2000 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | HBPTO* 1,697,2001 |
| skin/rat | lethal dose (50 percent kill): 800 mg/kg | RPZHAW 22,579,1971 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 11400 µg/kg | TOIZAG 17,60,1970 | |
| subcutaneous/mouse | lowest published lethal dose: 22.2 mg/kg | ARTODN 76,173,2002 | |
| subcutaneous/rat | lowest published toxic dose: 10 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | TXAPA9 219,151,2007 |
| subcutaneous/rat | lethal dose (50 percent kill): 56 mg/kg | YKYUA6 32,471,1981 | |
| Tank with water/Zebrafish | Lowest published lethal concentration: 100 mg/L/24H | Reproductive: Other developmental abnormalities | TIVIEQ 28,340,2014 |
| Tank with water/Zebrafish | Lowest published lethal concentration: 100 mg/L/48H | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Other developmental abnormalities | TIVIEQ 28,340,2014 |
| Tank with water/Zebrafish | lowest published toxic concentration: 100 mg/L/12H | Reproductive: Other developmental abnormalities | TIVIEQ 28,340,2014 |
| Tank with water/Zebrafish | lethal concentration (50 percent kill): 166.4 mg/L/24H | TIVIEQ 28,340,2014 | |
| Tank with water/Zebrafish | lethal concentration (50 percent kill): 146.3 mg/L/48H | TIVIEQ 28,340,2014 | |
| Tank with water/Zebrafish | lethal concentration (50 percent kill): 134.8 mg/L/96H | TIVIEQ 28,340,2014 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 100 mg/kg | GISAAA 41(8),82,1976 | |
| unreported route/rat | lethal dose (50 percent kill): 100 mg/kg | 30ZDA9 -,193,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 40 mg/kg/4W- intermittent | Immunological Including Allergic: Increase in humoral response | INIMP* 4,1223,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg/4W- intermittent | Endocrine: Changes in thymus weight Blood: Changes in spleen Immunological Including Allergic: Decrease in humoral immune response | INIMP* 4,1223,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 40 mg/kg/28D- intermittent | Immunological Including Allergic: Increase in humoral response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | INIMP* 4,1223,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg/28D- intermittent | Endocrine: Changes in thymus weight Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | INIMP* 4,1223,2004 |
| oral/rabbit | lowest published toxic dose: 534.36 mg/kg/1Y- intermittent | Kidney, Ureter, and Bladder: Interstitial nephritis Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 307,109,2013 |
| oral/rat | lowest published toxic dose: 255.3 mg/kg/6W- intermittent | Behavioral: Change in psychophysiological tests Liver: Changes in liver weight | EESADV 57,270,2004 |
| oral/rat | lowest published toxic dose: 85.1 mg/kg/2W- intermittent | Behavioral: Alteration of classical conditioning | EESADV 57,270,2004 |
| oral/rat | lowest published toxic dose: 864 mg/kg/13W- intermittent | Gastrointestinal: Other changes Biochemical: Metabolism (intermediary): Other | KHZDAN 22(6),584,1979 |
| oral/rat | lowest published toxic dose: 37500 µg/kg/50D- continuous | Brain and Coverings: Recordings from specific areas of CNS Endocrine: Changes in thymus weight Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 27,465,1974 |
| oral/rat | lowest published toxic dose: 180 mg/kg/30D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BECTA6 23,438,1979 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/50D- continuous | Behavioral: Change in psychophysiological tests | HBPTO* 2,1100,2001 |
| oral/rat | lowest published toxic dose: 238.28 mg/kg/4W- intermittent | Endocrine: Changes in thymus weight Blood: Changes in erythrocyte (RBC) count | TXCYAC 178,161,2002 |
| oral/rat | lowest published toxic dose: 238 mg/kg/4W- intermittent | Liver: Changes in liver weight Endocrine: Changes in adrenal weight | TXCYAC 178,161,2002 |
| oral/rat | lowest published toxic dose: 714 mg/kg/12W- intermittent | Liver: Changes in liver weight Endocrine: Changes in adrenal weight Endocrine: Changes in thymus weight | TXCYAC 178,161,2002 |
| subcutaneous/rat | lowest published toxic dose: 70 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 219,151,2007 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | NEJMAG 342,186,2000 | |
| TOXICOLOGY REVIEW | NETOX* 26,531,2005 | |
| TOXICOLOGY REVIEW | NETOX* 26,573,2005 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | HUTOX* -,683,1996 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | NBREV* 9,479,1985 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | TXCYAC 307,35,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,136,2013 | |
| TOXICOLOGY REVIEW | TOLED5 230,146,2014 | |
| TOXICOLOGY REVIEW | NETEEC 52,68,2015 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,203,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.5 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 2 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.05 mg/m3;short term exposure limit 2 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPOXUR-air | 10H time-weighted average 0.5 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code M1931; Number of Industries 15; Total Number of Facilities 2701; Number of Occupations 16; Total Number of Employees Exposed 27304; Total Number of Female Employees Exposed 4206 | |
| National Occupational Hazard Survey 1974 | Hazard Code M1931; Number of Industries 18; Total Number of Facilities 2519; Number of Occupations 14; Total Number of Employees Exposed 18098 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health