Camphor

RTECS #

EX1225000

CAS #

76-22-2
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

152.26

Molecular Formula

C₁₀H₁₆O

Synonyms

1,7,7-Trimethylbicyclo(2.2.1)-2-heptanone
2-Bornanone
2-Camphanone
2-Kamfanon (Czech)
2-Keto-1,7,7-trimethylnorcamphane
Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
Bornane, 2-oxo-
Camphor, natural
Camphor, synthetic
Camphor, synthetic (ACGIH:OSHA)
Formosa camphor
Gum camphor
Huile de camphre (French)
Japan camphor
Kampfer (German)
Laurel camphor
Matricaria camphor
Norcamphor, 1,7,7-trimethyl-

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	kidney/monkey	500 µmol/L/20H	FCTOD7 49,2035,2011
sister chromatid exchange	intraperitoneal/mouse	80 mg/kg	MUREAV 224,157,1989

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	Lowest published lethal concentration: 400 mg/m³/3H	Behavioral: Muscle contraction or spasticity	GISAAA 22(11),83,1957
inhalation/mouse	lethal concentration (50 percent kill): 450 mg/m³	Behavioral: Excitement Behavioral: Muscle contraction or spasticity Gastrointestinal: Nausea or vomiting	VCVPS* -,296,1998
inhalation/rat	lethal concentration (50 percent kill): 500 mg/m³		VCVPS* -,296,1998
intraperitoneal/cat	lowest published lethal dose: 400 mg/kg		HBAMAK 4,1289,1935
intraperitoneal/mouse	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Behavioral: Rigidity (includes catalepsy)	AJPAA4 30,857,1954
intraperitoneal/rat	lowest published lethal dose: 900 mg/kg	Behavioral: Convulsions or effect on seizure threshold	JPETAB 65,275,1939
oral/child	lowest published toxic dose: 51 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold	AJEMEN 7,41,1989
oral/Dog	lowest published lethal dose: 800 mg/kg		HBAMAK 4,1289,1935
oral/infant	lowest published lethal dose: 70 mg/kg	Eye: Mydriasis (pupilliary dilation) Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	AJPAA4 30,857,1954
oral/mouse	lethal dose (50 percent kill): 1310 mg/kg		SHGKA3 75,934,1975
oral/mouse	lowest published toxic dose: 15 mg/kg/5H	Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	PYTOEY 21,1298,2014
oral/rabbit	lowest published lethal dose: 2 gm/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Behavioral: Rigidity (includes catalepsy)	AJPAA4 30,857,1954
subcutaneous/frog	lowest published lethal dose: 240 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change	AEXPBL 50,199,1903
subcutaneous/mouse	lowest published lethal dose: 200 mg/kg	Behavioral: Excitement	HDTU** -,-,1933
subcutaneous/mouse	lowest published toxic dose: 7.6 mg/kg	Behavioral: Analgesia	PYTOEY 23,429,2016
subcutaneous/rat	lethal dose (50 percent kill): 70 mg/kg		CDGU** -,-,1934
unreported route/child	lowest published lethal dose: 100 mg/kg		YKYUA6 31,1499,1980
unreported route/human	lowest published toxic dose: 0.01 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression	VCVPS* -,296,1998
unreported route/man	lowest published lethal dose: 29 mg/kg		85DCAI 2,73,1970
unreported route/mouse	lowest published toxic dose: 7.6 mg/kg	Behavioral: Analgesia	JOETD7 203,11,2017

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 210 mg/m³/3H/7W- intermittent	Lung, Thorax, or Respiration: Emphysema	GISAAA 22(11),83,1957
inhalation/rabbit	lowest published toxic concentration: 33 mg/m³/3H/7W- intermittent	Brain and Coverings: Other degenerative changes Cardiac: Other changes Lung, Thorax, or Respiration: Emphysema	GISAAA 22(11),83,1957

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm;short term exposure limit 3 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JRPMAP 12,27,1974
TOXICOLOGY REVIEW		NTIS** PB293-503
TOXICOLOGY REVIEW		HUTOX* -,247,1996
TOXICOLOGY REVIEW		CLLID* 13,277,2009
TOXICOLOGY REVIEW		FCTOD7 81,9,2015

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,267,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 2 ppm (12 mg/m³)	DTLVS* 3,37,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (12 mg/m³), short term exposure limit 3 ppm (19 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (13 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (12 mg/m³), short term exposure limit 3 ppm (19 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (12 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.3 ppm (1.9 mg/m³), short term exposure limit 0.9 ppm (5.7 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (12 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 ppm (13 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (12 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 2 ppm (12 mg/m³), short term exposure limit 3 ppm (18 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 2 ppm (12 mg/m³);short term exposure limit 3 ppm (19 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 2 ppm (12 mg/m³); short term exposure limit 3 ppm (19 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 2 ppm (12 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (12.4 mg/m³); short term exposure limit 3 ppm (18.7 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 3 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (13 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 12 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 2 ppm, JAN1999
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2 ppm (13 mg/m³);short term exposure limit 3 ppm (19 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 2 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 2 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 2 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 2 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAMPHOR, synthetic-air	10H time-weighted average 2 mg/m³	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code X1190; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 1; Total Number of Employees Exposed 427; Total Number of Female Employees Exposed 176
National Occupational Exposure Survey 1983	Hazard Code 15800; Number of Industries 101; Total Number of Facilities 9166; Number of Occupations 87; Total Number of Employees Exposed 153554; Total Number of Female Employees Exposed 53187
National Occupational Hazard Survey 1974	Hazard Code 15800; Number of Industries 68; Total Number of Facilities 8356; Number of Occupations 63; Total Number of Employees Exposed 95578

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301
NTP Carcinogenesis studies; test completed (peer review), October 2000

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health