tert-Butyl alcohol

RTECS #

EO1925000

CAS #

75-65-0
See: NMAM or OSHA Methods

Updated

October 2016

Molecular Weight

74.14

Molecular Formula

C₄H₁₀O

Synonyms

1,1-Dimethylethanol
2-Methyl-2-propanol
2-Methylpropan-2-ol
2-Propanol, 2-methyl-
Alcool butylique tertiaire (French)
Arconol
Butanol tertiaire (French)
Butyl alcohol
Methanol, trimethyl-
NCI-C55367
t-Butanol
t-Butyl alcohol
t-Butyl hydroxide
tert-Butanol
tert-Butyl alcohol (OSHA)
Tertiary-Butyl alcohol
Trimethyl methanol
Trimethylcarbinol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL/24H	severe	NTIS** OTS0572351
skin /rabbit	500 µL/24H	mild	NTIS** OTS0572351

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	parenteral/other insects	12500 mg/kg	ENECEV 5,321,1989
mutation in microorganisms	/Salmonella typhimurium	2 mg/plate (+enzymatic activation step)	MUREAV 446,15,1999

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	2000 ppm/7H (1-19D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FAATDF 12,469,1989
inhalation/rat	3500 ppm/7H (1-19D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	FAATDF 12,469,1989
oral/mouse	103 gm/kg (6-20D pregnant)	Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JPETAB 222,294,1982
oral/mouse	135 gm/kg (6-20D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	JPETAB 222,294,1982
oral/mouse	20240 mg/kg (6-18D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	LIFSAK 45,1989,1989
oral/mouse	15000 mg/kg (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Other postnatal measures or effects	VCVGK* -,103,1994

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 1540 gm/kg/2Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors	NTPTR* NTP-TR-436,1995
oral/mouse	lowest published toxic dose: 749840 mg/kg/103W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Thyroid tumors	NTIS** PB96-162748
oral/mouse	lowest published toxic dose: 1521310 mg/kg/103W- continuous	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors	NTIS** PB96-162748
oral/mouse	lowest published toxic dose: 749840 mg/kg/103W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Thyroid tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV059 -,-,2002
oral/mouse	lowest published toxic dose: 735420 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Thyroid tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 146 gm/kg/2Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTPTR* NTP-TR-436,1995
oral/rat	lowest published toxic dose: 302820 mg/kg/103W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 144200 mg/kg/103W- continuous	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTIS** PB96-162748
oral/rat	lowest published toxic dose: 468650 mg/kg/103W- continuous	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTIS** PB96-162748

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
eye/human	lowest published toxic dose: 72.5 mg/m³	Eye: Conjunctiva irritation	VCVGK* -,103,1984
inhalation/rat	lethal concentration (50 percent kill): >10000 ppm/4H	Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Pulmonary emboli	NTIS** OTS0572351
inhalation/rat	lethal concentration (50 percent kill): 14100 ppm/4H	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	HPV059 -,-,2002
intraperitoneal/mouse	lethal dose (50 percent kill): 399 mg/kg	Liver: Other changes	RCOCB8 26,75,1979
intraperitoneal/mouse	lethal dose (50 percent kill): 900 mg/kg		VCVGK* -,102,1984
intravenous/mouse	lethal dose (50 percent kill): 1500 mg/kg		VCVGK* -,102,1984
oral/rabbit	lethal dose (50 percent kill): 3559 mg/kg	Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea	IMSUAI 41,31,1972
oral/rabbit	lethal dose (50 percent kill): 3600 mg/kg		VCVGK* -,102,1984
oral/rabbit	lowest published lethal dose: 3500 mg/kg		VCVGK* -,102,1984
oral/rabbit	lowest published toxic dose: 1408 mg/kg	Behavioral: General anesthetic	HPV059 -,-,2002
oral/rabbit	lethal dose (50 percent kill): 3558 mg/kg	Behavioral: General anesthetic Cardiac: Change in rate Lung, Thorax, or Respiration: Respiratory depression	HPV059 -,-,2002
oral/rat	lethal dose (50 percent kill): 3500 mg/kg		VCVGK* -,102,1984
oral/rat	lethal dose (50 percent kill): 2733 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 59 mg/kg	Behavioral: Wakefulness	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 530 mg/kg	Behavioral: Wakefulness Behavioral: Ataxia	HPV059 -,-,2002
oral/rat	lethal dose (50 percent kill): 3500 mg/kg	Behavioral: Wakefulness Behavioral: Ataxia	HPV059 -,-,2002
oral/rat	lethal dose (50 percent kill): 2743 mg/kg	Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Other changes	NTIS** OTS0572351
parenteral/frog	lowest published lethal dose: 12 gm/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity)	AIPTAK 50,296,1935
skin/guinea pig	lethal dose (50 percent kill): >10 mL/kg	Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Hair	NTIS** OTS0556680
skin/rabbit	lethal dose (50 percent kill): >2 gm/kg	Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0572351
skin/rabbit	lethal dose (50 percent kill): >2000 mg/kg	Blood: Hemorrhage Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV059 -,-,2002

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/5D- intermittent	Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	ATSUDG 8,418,1985
oral/mouse	lowest published toxic dose: 703 gm/kg/94D- continuous	Behavioral: Fluid intake Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 19,91,1992
oral/mouse	lowest published toxic dose: 6 gm/kg/5D- intermittent	Related to Chronic Data: Changes in testicular weight	NTIS** OTS0559651
oral/mouse	lowest published toxic dose: 370360 mg/kg/94D- intermittent	Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV059 -,-,2002
oral/mouse	lowest published toxic dose: 771740 mg/kg/94D- intermittent	Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV059 -,-,2002
oral/mouse	lowest published toxic dose: 604420 mg/kg/94D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV059 -,-,2002
oral/mouse	lowest published toxic dose: 1092280 mg/kg/94D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 40950 mg/kg/65W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 144200 mg/kg/103W- intermittent	Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 129780 mg/kg/103W- intermittent	Kidney, Ureter, and Bladder: Other changes Kidney, Ureter, and Bladder: Changes in kidney weight	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 468650 mg/kg/103W- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV059 -,-,2002
oral/rat	lowest published toxic dose: 73176 mg/kg/21D- continuous	Behavioral: Convulsions or effect on seizure threshold Behavioral: Withdrawal Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	PUOMA5 54,86,1976
oral/rat	lowest published toxic dose: 150 gm/kg/94D- continuous	Behavioral: Fluid intake Kidney, Ureter, and Bladder: Urine volume decreased or anuria Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 19,91,1992
oral/rat	lowest published toxic dose: 9545 µL/kg/10W- continuous	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 80,97,1995

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JACTDZ 8,627,1989
TOXICOLOGY REVIEW		TOSCF2 61,1,2001
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		IJTOFN 24,1,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 659,68,2008
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		MUREAV 653,99,2008
TOXICOLOGY REVIEW		MUREAV 795,7,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 100 ppm (300 mg/m³)	DTLVS* 3,32,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 100 ppm (303 mg/m³), short term exposure limit 150 ppm (455 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (62 mg/m³);KZW 80 ppm (248 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 100 ppm (307 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 50 ppm (150 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (150 mg/m³), short term exposure limit 75 ppm (230 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 100 ppm (300 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 20 ppm (62 mg/m³), 2011
Occupational Exposure Limit-ICELAND	short term exposure limit 50 ppm (150 mg/m³), skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 50 ppm (150 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 100 ppm (305 mg/m³), short term exposure limit 150 ppm (455 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 100 ppm (300 mg/m³);short term exposure limit 150 ppm (450 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 100 ppm (303 mg/m³); short term exposure limit 150 ppm (455 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (75 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (303 mg/m³); short term exposure limit 150 ppm (455 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 300 mg/m³, MAC(short term exposure limit) 450 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 50 ppm (150 mg/m³);short term exposure limit 75 ppm (250 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 20 ppm (60 mg/m³), KZG-week 80 ppm (240 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 300 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 100 ppm (300 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 100 ppm (308 mg/m³);short term exposure limit 150 ppm (462 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 100 ppm (300 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 100 ppm (300 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 100 ppm (300 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 100 ppm (300 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ALCOHOL-air	10H time-weighted average 100 ppm;short term exposure limit 150 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 14400; Number of Industries 128; Total Number of Facilities 10682; Number of Occupations 84; Total Number of Employees Exposed 171420; Total Number of Female Employees Exposed 26045
National Occupational Hazard Survey 1974	Hazard Code 14400; Number of Industries 11; Total Number of Facilities 820; Number of Occupations 25; Total Number of Employees Exposed 3121

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Alcohols I, 1400
NTP Carcinogenesis Studies (drinking water);some evidence:mouse,rat NTPTR* NTP-TR-436,1995
NTP Toxicity studies, RPT# TOX-53, October 2000

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health