sec-Butyl alcohol
RTECS #
EO1750000
CAS #
Updated
September 2013
Molecular Weight
74.14
Molecular Formula
C4H10O
Synonyms
(+-)-2-Butanol
1-Methyl propanol
1-Methyl-1-propanol
1-Methylpropyl alcohol
2-Butanol
2-Butyl alcohol
2-Hydroxybutane
Alcool butylique secondaire (French)
Butan-2-ol
Butanol secondaire (French)
Butanol-2
Butylene hydrate
CCS 301
DL-Butan-2-ol
dl-Methylethylcarbinol
Ethylmethyl carbinol
Methylethylcarbinol
Racemic-2-butanol
S.B.A.
s-Butanol
s-Butyl alcohol
sec-Butanol
sec-Butanol (ACGIH)
sec-Butyl alcohol (OSHA)
1-Methyl propanol
1-Methyl-1-propanol
1-Methylpropyl alcohol
2-Butanol
2-Butyl alcohol
2-Hydroxybutane
Alcool butylique secondaire (French)
Butan-2-ol
Butanol secondaire (French)
Butanol-2
Butylene hydrate
CCS 301
DL-Butan-2-ol
dl-Methylethylcarbinol
Ethylmethyl carbinol
Methylethylcarbinol
Racemic-2-butanol
S.B.A.
s-Butanol
s-Butyl alcohol
sec-Butanol
sec-Butanol (ACGIH)
sec-Butyl alcohol (OSHA)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 0.1 mL | severe | HPV376 -,-,2006 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 5000 ppm/7H (1-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 12,469,1989 |
| inhalation/rat | 7000 ppm/7H (1-19D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system | FAATDF 12,469,1989 |
| inhalation/rat | 5000 mg/kg (1-19D pregnant) | Reproductive: Other effects on female | HPV376 -,-,2006 |
| oral/rat | 284984 mg/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV376 -,-,2006 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 3300 ppm/51M | Behavioral: Ataxia | HPV376 -,-,2006 |
| inhalation/mouse | lowest published toxic concentration: 19800 ppm/40M | Behavioral: General anesthetic | HPV376 -,-,2006 |
| inhalation/mouse | lowest published toxic concentration: 11800 ppm/10M | Lung, Thorax, or Respiration: Respiratory depression | HPV376 -,-,2006 |
| inhalation/rat | lethal concentration (50 percent kill): 8000 ppm/4H | HPV376 -,-,2006 | |
| inhalation/rat | lethal concentration (50 percent kill): 48500 mg/m3/4H | VCVGK* -,102,1984 | |
| inhalation/rat | Lowest published lethal concentration: 16000 ppm/4H | Olfaction: Other olfaction effects Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes | SHELL* MSDS-5280-4 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 1067 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/hamster | lethal dose (50 percent kill): 1218 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 771 mg/kg | SCCUR* -,2,1961 | |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 277 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 1193 mg/kg | EVHPAZ 61,321,1985 | |
| intravenous/mouse | lethal dose (50 percent kill): 764 mg/kg | AIPTAK 135,330,1962 | |
| intravenous/rat | lethal dose (50 percent kill): 138 mg/kg | EVHPAZ 61,321,1985 | |
| oral/Dog | lowest published lethal dose: 2400 mg/kg | NTIS** OTS0572377 | |
| oral/rabbit | lethal dose (50 percent kill): 4893 mg/kg | Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea | IMSUAI 41,31,1972 |
| oral/rabbit | lowest published lethal dose: 3000 mg/kg | VCVGK* -,102,1984 | |
| oral/rabbit | lethal dose (50 percent kill): 4890 mg/kg | HPV376 -,-,2006 | |
| oral/rat | lethal dose (50 percent kill): 2054 mg/kg | HPV376 -,-,2006 | |
| oral/rat | lethal dose (50 percent kill): 2193 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Behavioral: Coma | NTIS** OTS0557575 |
| parenteral/frog | lowest published lethal dose: 15 gm/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) | AIPTAK 50,296,1935 |
| skin/rat | lethal dose (50 percent kill): >2000 mg/kg | HPV376 -,-,2006 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 500 ppm/6H/5D- intermittent | Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ATSUDG 8,418,1985 |
| inhalation/rat | lowest published toxic concentration: 500 ppm/5D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | HPV376 -,-,2006 |
| inhalation/rat | lowest published toxic concentration: 5000 ppm/90D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV376 -,-,2006 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 100 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 150 ppm (450 mg/m3) | DTLVS* 3,32,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 100 ppm (303 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 100 ppm (307 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 50 ppm (150 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (230 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 100 ppm (300 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 50 ppm (150 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 100 ppm (300 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 50 ppm (150 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (305 mg/m3);short term exposure limit 150 ppm (455 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 100 ppm (303 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 25 ppm (75 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 100 ppm (303 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 300 mg/m3, short term exposure limit 450 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 50 ppm (150 mg/m3);short term exposure limit 75 ppm (250 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 100 ppm (300 mg/m3), KZG-week 200 ppm (600 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 450 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 150 ppm (450 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 150 ppm (450 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 100 ppm (308 mg/m3);short term exposure limit 150 ppm (462 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 150 ppm (450 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 150 ppm (450 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 150 ppm (450 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 150 ppm (450 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO sec-BUTYL ALCOHOL-air | 10H time-weighted average 100 ppm;short term exposure limit 150 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 14410; Number of Industries 97; Total Number of Facilities 5896; Number of Occupations 72; Total Number of Employees Exposed 126196; Total Number of Female Employees Exposed 36723 | |
| National Occupational Hazard Survey 1974 | Hazard Code 14410; Number of Industries 59; Total Number of Facilities 2929; Number of Occupations 47; Total Number of Employees Exposed 42853 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health