1-Butanol, 3-methyl-

RTECS #

EL5425000

CAS #

123-51-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

88.17

Molecular Formula

C₅H₁₂O

Synonyms

2-Methyl-4-butanol
3-Methyl butanol
3-Methyl-1-butanol
3-Methylbutan-1-ol
3-Metil-butanolo (Italian)
Alcool amilico (Italian)
Alcool isoamylique (French)
Amylowy alkohol (Polish)
Fermentation amyl alcohol
Isoamyl alcohol
Isoamyl alcohol (ACGIH)
Isoamyl alcohol, primary (OSHA)
Isoamyl alkohol (Czech)
Iso-amylalkohol (German)
Isoamylol
Isobutylcarbinol
Isopentanol
Isopentyl alcohol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	150 ppm		JIHTAB 25,282,1943
eye /rabbit	20 mg/24H	moderate	85JCAE -,196,1986
skin /rabbit	20 mg/24H	moderate	85JCAE -,196,1986

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 27 gm/kg/75W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975
subcutaneous/rat	lowest published toxic dose: 3800 mg/kg/85W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Rat, neurons	Inhibitor Concentration Low: 2.5 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TOXRE* 2,729,2015
inhalation/human	lowest published toxic concentration: 150 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
intraperitoneal/mouse	lowest published lethal dose: 233 mg/kg		FCTXAV 16,785,1978
intraperitoneal/rat	lowest published lethal dose: 813 mg/kg		AEPPAE 132,214,1928
intravenous/cat	lowest published lethal dose: 210 mg/kg		FCTXAV 16,785,1978
intravenous/mouse	lethal dose (50 percent kill): 234 mg/kg		AIPTAK 135,330,1962
intravenous/rabbit	lowest published lethal dose: 1570 mg/kg	Behavioral: Antipsychotic	FCTXAV 16,785,1978
oral/rabbit	lethal dose (50 percent kill): 3438 mg/kg	Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea	IMSUAI 41,31,1972
oral/rat	lethal dose (50 percent kill): 1300 mg/kg	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes Blood: Other changes	SAMJAF 43,795,1969
oral/rat	lethal dose (50 percent kill): 4300 mg/kg		VCVGK* -,108,1984
skin/rabbit	lethal dose (50 percent kill): 3970 µL/kg		AIHAAP 30,470,1969
subcutaneous/mouse	lowest published lethal dose: 7480 mg/kg		FCTXAV 16,785,1978

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 125 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 539,77,2003

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 100 ppm (360 mg/m³)	DTLVS* 3,139,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 100 ppm (361 mg/m³), short term exposure limit 125 ppm (452 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 100 ppm(366 mg/m³), short term exposure limit 125 ppm(459 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 100 ppm (360 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 100 ppm (360 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 20 ppm (73 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 360 mg/m³, short term exposure limit 1440 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 100 ppm (360 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 100 ppm (360 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 100 ppm (360 mg/m³), short term exposure limit 125 ppm (450 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 100 ppm (360 mg/m³);short term exposure limit 125 ppm (450 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 100 ppm (361 mg/m³); short term exposure limit 125 ppm (452 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (360 mg/m³); short term exposure limit 125 ppm (450 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 20 ppm (73 mg/m³), KZG-week 80 ppm (292 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 360 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 100 ppm (366 mg/m³);short term exposure limit 125 ppm (458 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 100 ppm (360 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOAMYL ALCOHOL, primary-air	time-weighted average 100 ppm;short term exposure limit 125 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 40380; Number of Industries 43; Total Number of Facilities 3803; Number of Occupations 49; Total Number of Employees Exposed 65499; Total Number of Female Employees Exposed 22006
National Occupational Hazard Survey 1974	Hazard Code 40380; Number of Industries 16; Total Number of Facilities 2530; Number of Occupations 18; Total Number of Employees Exposed 24606

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health