Biphenyl, 4-nitro-
RTECS #
DV5600000
CAS #
Updated
June 2017
Molecular Weight
199.22
Molecular Formula
C12H9NO2
Synonyms
4-Nitrobiphenyl
4-Nitrodiphenyl
4-Nitrodiphenyl (ACGIH)
4-Phenyl-nitrobenzene
PNB
p-Nitrobiphenyl
p-Nitrodiphenyl
p-Phenyl-nitrobenzene
4-Nitrodiphenyl
4-Nitrodiphenyl (ACGIH)
4-Phenyl-nitrobenzene
PNB
p-Nitrobiphenyl
p-Nitrodiphenyl
p-Phenyl-nitrobenzene
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
body fluid assay | Salmonella typhimurium/rat | 400 mg/kg/4D | PNASA6 72,4607,1975 |
DNA adduct | /Escherichia coli | 50 µmol/L | MUREAV 89,95,1981 |
DNA adduct | oral/Dog | 60 µmol/kg | EVHPAZ 49,125,1983 |
DNA Damage | other cell types/human | 60 µmol/L | EMMUEG 38,1,2001 |
DNA Damage | liver/rat | 300 µmol/L | SinJF# 26OCT1982 |
DNA repair | /Escherichia coli | 250 mg/L | JJIND8 62,873,1979 |
host-mediated assay | Salmonella typhimurium/rat | 750 mg/kg/3D | AJCNAC 30,1921,1977 |
morphological transform | kidney/hamster | 80 µg/L | BJCAAI 37,873,1978 |
morphological transform | embryo/hamster | 100 µg/L | IJCNAW 19,642,1977 |
mutation in microorganisms | /Salmonella typhimurium | 20 µg/plate/48H (+/-enzymatic activation step) | MUREAV 491,195,2001 |
mutation in microorganisms | lymphocyte/mouse | 77600 µg/L (+enzymatic activation step) | MUREAV 97,49,1982 |
mutation in microorganisms | /Bacillus subtilis | 50 mmol/L (-enzymatic activation step) | EXPEAM 39,530,1983 |
mutation in microorganisms | /Salmonella typhimurium | 40 µg/plate (+enzymatic activation step) | MUREAV 172,37,1986 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate (-enzymatic activation step) | ESKGA2 29,63,1983 |
sister chromatid exchange | intraperitoneal/hamster | 100 mg/kg | MUREAV 113,33,1983 |
sister chromatid exchange | ovary/hamster | 10 µmol/L | ENMUDM 4,1,1982 |
sister chromatid exchange | oral/hamster | 125 mg/kg | MUREAV 113,33,1983 |
Unscheduled DNA Synthesis | liver/rat | 100 µmol/L | ENMUDM 3,11,1981 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 7000 mg/kg/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | JAMAAP 172,1611,1960 |
oral/Dog | toxic dose: 7000 mg/kg/3Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | IMSUAI 27,634,1958 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lethal dose (50 percent kill): 347 mg/kg | JJIND8 62,911,1979 | |
oral/rabbit | lethal dose (50 percent kill): 1970 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 29,1,1947 |
oral/rat | lethal dose (50 percent kill): 2230 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JIHTAB 29,1,1947 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Control as low as possible (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Suspected human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 4,113,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 4,113,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
TOXICOLOGY REVIEW | ADCSAJ 13,271,1970 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | HUMAN CARCINOGEN | DTLWS* 3,24,1973 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | Carcinogen, JUL2008 | |
Occupational Exposure Limit-BELGIUM | Skin, MAR2002 | |
Occupational Exposure Limit-KOREA | carcinogen, skin, 2006 | |
Occupational Exposure Limit-NEW ZEALAND | skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.01 mg/m3, JAN1999 | |
Occupational Exposure Limit-SWEDEN | Group A Carcinogen, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | carc 2, JAN2011 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | see Code of Federal Regulations (CFR) 29,1926.1103 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA)-cancer suspect agent | CFRGBR 29,1910.1003,1987 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-NITROBIPHENYL-air | Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1003 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health